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Item type:Item, The Hybrid Solar-RF Energy for Base Transceiver Stations(2020-07-14) ;Nguyen, Cuong, V ;Nguyen, Minh T. ;Quyen, Toan, V ;Le, Anh M.Truong, Linh H.The base transceiver stations (BTS) are telecom infrastructures that facilitate wireless communication between the subscriber device and the telecom operator networks. They are deployed in suitable places having a lot of freely propagating ambient radio frequency (RF) and solar energies. This paper is aimed at converting received ambient environmental energy into usable electricity to power the stations. We proposed a hybrid energy harvesting system that can collect energy from RF and solar energies at the same time. The sources are combined to provide to a significant amount, to contribute to operational expenditures that reduce energy costs, and to improve the energy efficiency of the base station sites in rural areas from the most common renewable resources since the base stations are major consumers of cellular networks. The hybrid systems are designed with circuits, simulated, and compared to show their good performance to the base stations. PSIM, PROTEUS, and MATLAB software are used to simulate for evaluating the voltage and the current output of the hybrid systems that meet the power requirements. The design and simulation results show the feasibility of our proposed method with the battery storage that can be deployed not only in real base stations but also for other electrical operated systems.Item type:Item, How Does Gender Stereotype Affect the Memory of Advertisements? A Behavioral and Electroencephalography Study(2020-07-14) ;Lo, Shih-Yu ;King, Jung-Tai ;Lin, Chin-Teng ;傳播研究所通識教育中心Previous studies have shown equivocal results about whether atypical or unusual events, compared with typical ones, facilitate or inhibit memory. We suspect that the indefinite findings could be partly due to the recall task used in these studies, as the participants might have used inference instead of recall in their responses. In the present study, we tested the recognition memory for real (Experiment 1) and fabricated (Experiment 2) advertisements, which could be congruent or incongruent with gender stereotypes. In congruent advertisements, a female endorser presented a traditionally considered feminine product or a male endorser presented a traditionally considered masculine product, whereas the gender-product type matching reversed in incongruent advertisements. The results of both behavioral experiments revealed that the participants' memory performance for stereotype-incongruent advertisements was higher than for congruent ones. In the event-related potential (ERP) recordings in Experiment 3, larger positive amplitudes were found for stereotype-incongruent advertisements than for congruent advertisements on the left parietal sites, suggesting a deeper encoding process for stereotype-incongruent information than for stereotype-congruent information.Item type:Item, Controlling the visible-light driven photocatalytic activity of alloyed ZnSe-AgInSe(2)quantum dots for hydrogen production(2020-07-14) ;Hsieh, Ping-Yen ;Kameyama, Tatsuya ;Takiyama, Takayuki ;Masuoka, KoYamamoto, TakahisaBinary semiconductor quantum dots such as CdS and CdSe have been widely studied as photocatalysts for hydrogen production, but the high toxicity of Cd impedes their widespread deployment. Recently, multinary I-III-VI-based semiconductors,e.g., AgInS(2)and CuInS2, have emerged as promising alternatives for environmentally benign photocatalysts. In this work, we prepared quantum dots (QDs) composed of an alloyed ZnSe-AgInSe2(ZAISe) semiconductor and evaluated their photocatalytic activity for hydrogen (H-2) production. By individually controlling the fractions of Zn and Ag, that is, the ratios of (Ag + In)/(Zn + Ag + In) and Ag/(Ag + In), the band structure of ZAISe QDs could be finely tuned to improve their photocatalytic activity. The action spectra of the photocatalytic reaction of ZAISe QDs revealed vigorous activity across the whole visible region from 400 to 700 nm. The highest apparent quantum yield of H(2)production reached 3.4% under irradiation at 600 nm.Item type:Item, Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation(2020-07-14) ;Tsai, Meng-Han ;Cheng, Haw-Yuan ;Nian, Fang-Shin ;Liu, ChenChao, Nian-HsinDuring brain development, the nucleus of migrating neurons follows the centrosome and translocates into the leading process. Defects in these migratory events, which affect neuronal migration, cause lissencephaly and other neurodevelopmental disorders. However, the mechanism of nuclear translocation remains elusive. Using whole exome sequencing (WES), we identified a novel nonsense BICD2 variant p.(Lys775Ter) (K775X) from a lissencephaly patient. Interestingly, most BICD2 missense variants have been associated with human spinal muscular atrophy (SMA) without obvious brain malformations. By in utero electroporation, we showed that BicD2 knockdown in mouse embryos inhibited neuronal migration. Surprisingly, we observed severe blockage of neuronal migration in cells overexpressing K775X but not in those expressing wild-type BicD2 or SMA-associated missense variants. The centrosome of the mutant was, on average, positioned farther away from the nucleus, indicating a failure in nuclear translocation without affecting the centrosome movement. Furthermore, BicD2 localized at the nuclear envelope (NE) through its interaction with NE protein Nesprin-2. K775X variant disrupted this interaction and further interrupted the NE recruitment of BicD2 and dynein. Remarkably, fusion of BicD2-K775X with NE-localizing domain KASH resumed neuronal migration. Our results underscore impaired nuclear translocation during neuronal migration as an important pathomechanism of lissencephaly.Item type:Item, Item type:Item, 【腦科學研究中心學術專題演講】機器學習經驗分享~在醫療數據與商標數據上的應用(國立陽明大學, 2020-07-15)陽明電子報編輯小組日期:7月17日(五) 時間:12:00-13:30 講者:陳翎博士.Item type:Item, Item type:Item, 高雄市國立陽明大學校友會—109年上半年精彩活動回顧(國立陽明大學, 2020-07-15)陽明電子報編輯小組高雄陽明校友會去年底舉辦多場聯誼活動後,直至近期疫情稍緩,逐漸開啟以戶外活動為主的多場健行活動,親子共遊,聯繫情誼。Item type:Item, Item type:Item, Bispecific antibody (HER2 x mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes(2020-07-15) ;Chen, I-Ju ;Cheng, Yi-An ;Ho, Kai-Wen ;Lin, Wen-WeiCheng, Kai-WenTargeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the anti-cancer effects of targeted antibodies combined with mPEGylated liposomes (mPEG-liposomes), we describe a bispecific antibody in which an anti-methoxy-polyethylene glycol scFv (alpha mPEG scFv) was fused to the C-terminus of an anti-HER2 (alpha HER2) antibody to generate a HER2 x mPEG BsAb that retained the original efficacy of a targeted antibody while actively attracting mPEG-liposomes to accumulate at tumor sites. HER2 xmPEG BsAb can simultaneously bind to HER2high expressing MCF7/HER2 tumor cells and mPEG molecules on mPEG-liposomal doxorubicin (Lipo-Dox). Pre-incubation of HER2 x mPEG BsAb with cells increased the endocytosis of Lipo-DiD and enhanced the cytotoxicity of Lipo-Dox to MCF7/HER2 tumor cells. Furthermore, pre-treatment of HER2 x mPEG BsAb enhanced the tumor accumulation and retention of Lipo-DiR 2.2-fold in HER2-high expressing MCF7/HER2 tumors as compared to HER2-low expressing MCF7/neol tumors. Importantly, HER2 x mPEG BsAb plus Lipo-Dox significantly suppressed tumor growth as compared to control BsAb plus Lipo-Dox in MCF7/HER2 tumor-bearing mice. These results indicate that HER2 x mPEG BsAb can enhance tumor accumulation of mPEG-liposomes to improve the therapeutic efficacy of combination treatment. Anti-mPEG scFv can be fused to any kind of targeted antibody to generate BsAbs to actively attract mPEG-drugs and improve anti-cancer efficacy. Statement of Significance Antibody targeted therapy and PEGylated drugs have gradually become the mainstream of cancer therapy. To enhance the anti-cancer effects of targeted antibodies combined with PEGylated drugs is very important. To this aim, we fused an anti-PEG scFv to the C-terminal of HER2 targeted antibodies to generate a HER2xmPEG bispecific antibody (BsAb) to retain the original efficacy of targeted antibody whilst actively attract mPEG-liposomal drugs to accumulate at tumor sites. The present study demonstrates pretreatment of HER2xmPEG BsAb can enhance tumor accumulation of mPEG-liposomal drugs to improve the therapeutic efficacy of combination treatment. Anti-mPEG scFv can be fused to any kind of targeted antibody to generate BsAbs to actively attract mPEG-drugs and improve anti-cancer efficacy. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.Item type:Item, Item type:Item, 【校友中心~持本校證件享特約商店服務】(國立陽明大學, 2020-07-15)陽明電子報編輯小組本校特約商店提供師生校友們美食、住宿、交通、醫療、購物等優惠,今年並新增多家廠商,更感謝有開業院長校友支持! 所有優...Item type:Item, 獲獎、榮陞及返校訊息(國立陽明大學, 2020-07-15)陽明電子報編輯小組2020年,熱情的夏日來臨,也熱烈分享多位陽明校友的好消息!有獲獎喜訊、步步高陞、特別受邀返校等,是陽明人的驕傲~請大家給予掌聲歡呼唷!也祝福所有校友們都能事業順展,幸福平安!Item type:Item, 陽明大學牙醫校友總會—109年上半年精彩活動回顧(國立陽明大學, 2020-07-15)陽明電子報編輯小組陽明大學牙醫校友總會6月15日迎新聯誼餐會活動,盛大歡迎最新出爐熱血沸騰第39屆畢業生加入牙醫校友總會的大家庭,增添精彩回憶Item type:Item, 分子醫學博士學位學程羅芊卉同學獲「台灣傑出女科學家獎」肯定(國立陽明大學, 2020-07-15)陽明電子報編輯小組專為表揚台灣女科學家卓越貢獻的「台灣傑出女科學家獎」,日前公布2020年第13屆得獎名單。其中鼓勵年輕博士班學生具科學潛力的Item type:Item, Item type:Item, Item type:Item, High-power structured laser modes: direct generation of a vortex array(2020-07-15) ;Chen, Y. F. ;Ke, H. T. ;Tseng, Y. C. ;Hsieh, M. X.Tung, J. C.The frequency degeneracy induced by the astigmatism in a nearly hemispherical cavity is originally exploited to generate vortex array laser modes with the output power up to 300 mW. The inhomogeneous Helmholtz equation is employed to derive the wave function for manifesting the characteristics of the lasing modes. The theoretical wave function explicitly reveals the role of the Gouy phase in the formation of vortex arrays. Numerical analyses are further performed to confirm that the thermal lensing effect in the laser crystal assists the lasing transverse order to increase with increasing pump power. It is believed that the high efficiency enables the present laser modes to be useful in the applications of structured vortex beams. (C) 2020 Optical Society of AmericaItem type:Item, Marimo-Bead-Supported Core-Shell Nanocomposites of Titanium Nitride and Chromium-Doped Titanium Dioxide as a Highly Efficient Water-Floatable Green Photocatalyst(2020-07-15) ;Kaur, Manpreet ;Shinde, Satish Laxman ;Ishii, Satoshi ;Jevasuwan, WipakornFukata, NaokiThe release of untreated industrial wastewater creates a hazardous impact on the environment. In this regard, the development of an environmentally friendly catalyst is of paramount importance. Here, we report a highly efficient and reusable core-shell TiN/SiO2/Cr-TiO2 (TSCT) photocatalyst that is composed of SiO2-cladded titanium nitride (TiN) nanoparticles (NPs) decorated with Cr-doped TiO2 NPs for the removal of organic contaminants from water. The TiN NPs serve as the main light absorber component with excellent visible-light absorption along with Cr-TiO2 NPs. The TSCT shows remarkable improvement in the photodecomposition of methylene blue (MB) over Cr-TiO2 and TiO2 NPs. An efficient structural design is proposed by adopting calcium alginate beads (P-Marimo beads) as a transparent scaffold for supporting our TSCT, which floats nature on the water surface and realizes easy handling as well as excellent reusability for multipurpose water purification. Surprisingly, our TSCT is found to keep its catalytic activity even after the illumination is turned off. Our proposed P-Marimo-encapsulated TSCT can be utilized as an excellent green photocatalyst with high photocatalytic performance, good recyclability, and easy handling.Item type:Item, 《賣場華爾滋》(In the Aisles)(國立陽明大學, 2020-07-15) ;黃柏威陽明電子報編輯小組