Browsing by Issue Date, starting with "2020-07-15"

Now showing 1 - 20 of 4652

【醫放系～11/15歡迎系友回娘家】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
醫放系系友回娘家暨三十周年創系紀念活動，將於11/15（日）於本
【腦科學研究中心學術專題演講】機器學習經驗分享～在醫療數據與商標數據上的應用
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
日期：7月17日（五）時間：12:00-13:30 講者：陳翎博士.
【醫放系～7/19系友情人湖健行聯誼活動】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
陽明醫放系系友會將於7/19（日）9:30 情人湖，舉辦健行及啖海鮮
高雄市國立陽明大學校友會—109年上半年精彩活動回顧
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
高雄陽明校友會去年底舉辦多場聯誼活動後，直至近期疫情稍緩，逐漸開啟以戶外活動為主的多場健行活動，親子共遊，聯繫情誼。
【圖書館～校友免費紙本文獻傳遞服務】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
您是否畢業後即苦惱無法使用圖書館的期刊文獻？尤其地處偏遠.
Bispecific antibody (HER2 x mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes
(2020-07-15)
Chen, I-Ju
;
Cheng, Yi-An
;
Ho, Kai-Wen
;
Lin, Wen-Wei
;
Cheng, Kai-Wen
Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the anti-cancer effects of targeted antibodies combined with mPEGylated liposomes (mPEG-liposomes), we describe a bispecific antibody in which an anti-methoxy-polyethylene glycol scFv (alpha mPEG scFv) was fused to the C-terminus of an anti-HER2 (alpha HER2) antibody to generate a HER2 x mPEG BsAb that retained the original efficacy of a targeted antibody while actively attracting mPEG-liposomes to accumulate at tumor sites. HER2 xmPEG BsAb can simultaneously bind to HER2high expressing MCF7/HER2 tumor cells and mPEG molecules on mPEG-liposomal doxorubicin (Lipo-Dox). Pre-incubation of HER2 x mPEG BsAb with cells increased the endocytosis of Lipo-DiD and enhanced the cytotoxicity of Lipo-Dox to MCF7/HER2 tumor cells. Furthermore, pre-treatment of HER2 x mPEG BsAb enhanced the tumor accumulation and retention of Lipo-DiR 2.2-fold in HER2-high expressing MCF7/HER2 tumors as compared to HER2-low expressing MCF7/neol tumors. Importantly, HER2 x mPEG BsAb plus Lipo-Dox significantly suppressed tumor growth as compared to control BsAb plus Lipo-Dox in MCF7/HER2 tumor-bearing mice. These results indicate that HER2 x mPEG BsAb can enhance tumor accumulation of mPEG-liposomes to improve the therapeutic efficacy of combination treatment. Anti-mPEG scFv can be fused to any kind of targeted antibody to generate BsAbs to actively attract mPEG-drugs and improve anti-cancer efficacy. Statement of Significance Antibody targeted therapy and PEGylated drugs have gradually become the mainstream of cancer therapy. To enhance the anti-cancer effects of targeted antibodies combined with PEGylated drugs is very important. To this aim, we fused an anti-PEG scFv to the C-terminal of HER2 targeted antibodies to generate a HER2xmPEG bispecific antibody (BsAb) to retain the original efficacy of targeted antibody whilst actively attract mPEG-liposomal drugs to accumulate at tumor sites. The present study demonstrates pretreatment of HER2xmPEG BsAb can enhance tumor accumulation of mPEG-liposomal drugs to improve the therapeutic efficacy of combination treatment. Anti-mPEG scFv can be fused to any kind of targeted antibody to generate BsAbs to actively attract mPEG-drugs and improve anti-cancer efficacy. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
【圖書館～加入圖書館年費會員即獲限量神農之境】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
歡迎校友加入圖書館榮譽之友年費會員，相關辦法請參考： https
【校友中心～持本校證件享特約商店服務】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
本校特約商店提供師生校友們美食、住宿、交通、醫療、購物等優惠，今年並新增多家廠商，更感謝有開業院長校友支持！所有優...
獲獎、榮陞及返校訊息
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
2020年，熱情的夏日來臨，也熱烈分享多位陽明校友的好消息！有獲獎喜訊、步步高陞、特別受邀返校等，是陽明人的驕傲～請大家給予掌聲歡呼唷！也祝福所有校友們都能事業順展，幸福平安！
陽明大學牙醫校友總會—109年上半年精彩活動回顧
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
陽明大學牙醫校友總會6月15日迎新聯誼餐會活動，盛大歡迎最新出爐熱血沸騰第39屆畢業生加入牙醫校友總會的大家庭，增添精彩回憶
分子醫學博士學位學程羅芊卉同學獲「台灣傑出女科學家獎」肯定
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
專為表揚台灣女科學家卓越貢獻的「台灣傑出女科學家獎」，日前公布2020年第13屆得獎名單。其中鼓勵年輕博士班學生具科學潛力的
【ATLife 2020臺灣輔具暨長期照護大展】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
今年全球唯一輔具展，就在台灣ATLife！國際前兩大輔具專門展
【職發組～103、105、107學年度畢業校友現況調查】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
【2020畢業校友現況調查】103、105、107學年度畢業校友～填問卷
High-power structured laser modes: direct generation of a vortex array
(2020-07-15)
Chen, Y. F.
;
Ke, H. T.
;
Tseng, Y. C.
;
Hsieh, M. X.
;
Tung, J. C.
The frequency degeneracy induced by the astigmatism in a nearly hemispherical cavity is originally exploited to generate vortex array laser modes with the output power up to 300 mW. The inhomogeneous Helmholtz equation is employed to derive the wave function for manifesting the characteristics of the lasing modes. The theoretical wave function explicitly reveals the role of the Gouy phase in the formation of vortex arrays. Numerical analyses are further performed to confirm that the thermal lensing effect in the laser crystal assists the lasing transverse order to increase with increasing pump power. It is believed that the high efficiency enables the present laser modes to be useful in the applications of structured vortex beams. (C) 2020 Optical Society of America
Marimo-Bead-Supported Core-Shell Nanocomposites of Titanium Nitride and Chromium-Doped Titanium Dioxide as a Highly Efficient Water-Floatable Green Photocatalyst
(2020-07-15)
Kaur, Manpreet
;
Shinde, Satish Laxman
;
Ishii, Satoshi
;
Jevasuwan, Wipakorn
;
Fukata, Naoki
The release of untreated industrial wastewater creates a hazardous impact on the environment. In this regard, the development of an environmentally friendly catalyst is of paramount importance. Here, we report a highly efficient and reusable core-shell TiN/SiO2/Cr-TiO2 (TSCT) photocatalyst that is composed of SiO2-cladded titanium nitride (TiN) nanoparticles (NPs) decorated with Cr-doped TiO2 NPs for the removal of organic contaminants from water. The TiN NPs serve as the main light absorber component with excellent visible-light absorption along with Cr-TiO2 NPs. The TSCT shows remarkable improvement in the photodecomposition of methylene blue (MB) over Cr-TiO2 and TiO2 NPs. An efficient structural design is proposed by adopting calcium alginate beads (P-Marimo beads) as a transparent scaffold for supporting our TSCT, which floats nature on the water surface and realizes easy handling as well as excellent reusability for multipurpose water purification. Surprisingly, our TSCT is found to keep its catalytic activity even after the illumination is turned off. Our proposed P-Marimo-encapsulated TSCT can be utilized as an excellent green photocatalyst with high photocatalytic performance, good recyclability, and easy handling.
《賣場華爾滋》（In the Aisles）
(國立陽明大學, 2020-07-15)
黃柏威
;
陽明電子報編輯小組
為什麼我們老是做錯決定？陽明神研所發現人類估算機率的神經基礎
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
多比較才不會吃虧？陽明神經科學研究所顛覆傳統印象，首度發現人類大腦往往因為「比較」才導致決策偏誤，讓人腦在經歷一連串低機.
科社所彭松嶽老師榮獲「中研院年輕學者研究著作獎」
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
「中央研究院年輕學者研究著作獎」2020年得獎名單於7月9日公布，本校科技與社會研究所彭松嶽助理教授以「數位創新與公眾參與」系.
Ultra-high annealing twin density in < 211 >-oriented Cu films
(2020-07-15)
Chen, Kuan-Ju
;
Chen, Jui-Yuan
;
Ting, Yi-Hsin
;
Wu, Wen-Wei
;
Chen, Chih
We reported the fabrication of densely twinned Cu films with highly (211) texture developed from the annealing of <111>-oriented nanotwinned copper (nt-Cu) films. During the annealing at 300 degrees C, abnormal grain growth occurred in the nt-Cu film and resulted in a microstructure dominated by the anomalously large <211>-oriented grains. Moreover, densely-intersected annealing twin bands with <221>, <611>, and <931> orientations are embedded in the large <211> grains. The measured annealing twin density is 0.2 mu m(-1), which is highest among the reported values in previous literatures with similar grain size. Extensive multiple twinning process may occur during the annealing to form the unique microstructure. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
【校友總會～第七屆第一次會員大會預告】
(國立陽明大學, 2020-07-15)
陽明電子報編輯小組
校友總會第七屆第一次會員大會，將於10/25（日）舉行，地點於本