Browsing by Issue Date, starting with "2020-08-27"

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Humanized bispecific antibody (mPEG x HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer
(2020-08-27)
Cheng, Yi-An
;
Wu, Tung-Ho
;
Wang, Yun-Ming
;
Cheng, Tian-Lu
;
Chen, I-Ju
Background: Developing a universal strategy to improve the specificity and sensitivity of PEGylated nanoaparticles (PEG-NPs) for assisting in the diagnosis of tumors is important in multimodality imaging. Here, we developed the anti-methoxypolyethylene glycol (mPEG) bispecific antibody (BsAb; mPEG x HER2), which has dual specificity for mPEG and human epidermal growth factor receptor 2 (HER2), with a diverse array of PEG-NPs to confer nanoparticles with HER2 specificity and stronger intensity. Result: We used a one-step formulation to rapidly modify the nanoprobes with mPEG x HER2 and optimized the modified ratio of BsAbs on several PEG-NPs (Lipo-DiR, SPIO, Qdot and AuNP). The alpha HER2/PEG-NPs could specifically target MCF7/HER2 cells (HER2(++)) but not MCF7/neo1 cells (HER2(+/-)). The alpha HER2/Lipo-DiR and alpha HER2/SPIO could enhance the sensitivity of untargeted PEG-NPs on MCF7/HER2 (HER2(++)). In in vivo imaging, alpha HER2/Lipo-DiR and alpha HER2/SPIO increased the specific targeting and enhanced PEG-NPs accumulation at 175% and 187% on 24 h, respectively, in HER2-overexpressing tumors. Conclusion: mPEG x HER2, therefore, provided a simple one-step formulation to confer HER2-specific targeting and enhanced sensitivity and contrast intensity on HER2 positive tumors for multimodality imaging.
Tuning proton-coupled electron transfer by crystal orientation for efficient water oxidization on double perovskite oxides
(2020-08-27)
Zhu, Yunmin
;
He, Zuyun
;
Choi, YongMan
;
Chen, Huijun
;
Li, Xiaobao
Developing highly efficient and cost-effective oxygen evolution reaction (OER) electrocatalysts is critical for many energy devices. While regulating the proton-coupled electron transfer (PCET) process via introducing additive into the system has been reported effective in promoting OER activity, controlling the PCET process by tuning the intrinsic material properties remains a challenging task. In this work, we take double perovskite oxide PrBa0.5Sr0.5Co1.5Fe0.5O5+delta (PBSCF) as a model system to demonstrate enhancing OER activity through the promotion of PCET by tuning the crystal orientation and correlated proton diffusion. OER kinetics on PBSCF thin films with (100), (110), and (111) orientation, deposited on single crystal LaAlO3 substrates, were investigated using electrochemical measurements, density functional theory (DFT) calculations, and synchrotron-based near ambient X-ray photoelectron spectroscopy. The results clearly show that the OER activity and the ease of deprotonation depend on orientation and follow the order of (100) > (110) > (111). Correlated with OER activity, proton diffusion is found to be the fastest in the (100) film, followed by (110) and (111) films. Our results point out a way of boosting PCET and OER activity, which can also be successfully applied to a wide range of crucial applications in green energy and environment. Proton-coupled electron transfer (PCET) has been observed in chemical, energy, and biological transformation processes. Here we demonstrate that the rate of PCET and oxygen evolution reaction can be dramatically enhanced by tuning crystal orientation and the correlated proton diffusion.
Preliminary clinical and radiographic outcomes of proximal humeral fractures: comparison of ALPS and PHILOS plating in Asian patients in Taiwan
(2020-08-28)
Chen, Chun-Yen
;
Chang, Hao-Wei
;
Hsieh, Shang-Lin
;
Chang, Chien-Chun
;
Tsai, Chun-Hao
Background Up to 20% of proximal humeral fractures need to be treated operatively. However, numerus complications were reported by using fixed angled locking plates. The ALPS Proximal Humerus Plating System is a new design implant with novel design features. The aim of this study was to compare the preliminary clinical outcomes and complications of proximal humeral fractures treated with either ALPS or the proximal humeral internal locking system (PHILOS) in Asian patients in Taiwan. Methods Between January 2016 and December 2018, 66 patients with displaced proximal humeral fractures were analyzed retrospectively, of whom 31 underwent ALPS implant treatment and 35 underwent PHILOS implant treatment. Intraoperative blood loss and operation time, postoperative Constant-Murley Shoulder Outcome (Constant-Murley) score, and complications variables were recorded for the comparison. All cases were regularly followed up for at least 1 year. Results The mean follow-up period was 400.8 days (range, 367-446 days). Union was achieved in 98.5% of patients (65/66). The ALPS group yielded similar radiologic and clinical outcomes to the PHILOS plating group for treating displaced proximal humeral fractures, including operation time, intraoperative blood loss, the Constant-Murley score, and varus malunion (P> 0.05, respectively). However, the incidence of total postoperative complications in the ALPS group was significantly lower than in the PHILOS group (P< 0.05). There was a trend of a lower complication rate of screws/pegs protrusion, avascular necrosis, subacromial impingement, postoperative infection, and reoperation in the ALPS group, although it was not statistically significant (P> 0.05, respectively). Conclusion The ALPS group yielded similar radiologic and clinical outcomes to the PHILOS plating group for displaced proximal humeral fractures, but the ALPS group had a significantly lower total rate of complications. Therefore, ALPS may be a better option for treating proximal humeral fractures. Further larger clinical studies are needed to confirm the findings presented here.
【生醫領航方舟系列活動13】台灣生醫科技王富美董事長主講
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
由台灣生醫科技王富美董事長主講的「To go or not to go, it is..
陽明、交大攜手中華電信，發展5G AIoT智慧醫療應用服務
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
因應5G、AIoT智慧醫療發展趨勢，中華電信、交通大學、陽明大學三方共同簽訂產學技術合作意向書，結合三方各自優勢，交通大學為台
陽明男網全大運旗開得勝，勇奪北區預賽冠軍
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
陽明男子網球隊今年全大運旗開得勝，在北區預賽擊敗眾多強敵，奪得一般男子組冠軍；也順利取得晉級資格，將在今年10月決賽中，與1
【2020陽明大學人社講座】
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
台灣，我們的家，也曾被稱為福爾摩莎、蓬萊、寶島。在這塊土地.
陽明與交大合校案獲行政院通過
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
歷經近二十年努力，國立陽明大學與國立交通大學合併案，8月12日終獲行政院同意，將自110年2月1日起合併為「國立陽明交通大學」。
A Fast Route Towards Freestanding Single-Crystalline Oxide Thin Films by Using YBa(2)Cu(3)O(7-x)as a Sacrificial Layer
(2020-08-28)
Chang, Yao-Wen
;
Wu, Ping-Chun
;
Yi, Jhih-Bang
;
Liu, Yu-Chen
;
Chou, Yi
Researchers have long been seeking multifunctional materials that can be adopted for next-generation nanoelectronics, and which, hopefully, are compatible with current semiconductor processing for further integration. Along this vein, complex oxides have gained numerous attention due to their versatile functionalities. Despite the fact that unbounded potential of complex oxides has been examined over the past years, one of the major challenges lies in the direct integration of these functional oxides onto existing devices or targeted substrates that are inherently incompatible in terms of oxide growth. To fulfill this goal, freestanding processes have been proposed, in which wet etching of inserted sacrificial layers is regarded as one of the most efficient ways to obtain epitaxial high-quality thin films. In this study, we propose using an alternative oxide, YBa2Cu3O7(YCBO), as a sacrificial layer, which can be easily dissolved in light hydrochloric acid in a more efficient way, while protecting selected complex oxides intact. The high epitaxial quality of the selected complex oxide before and after freestanding process using YBCO as a sacrificial layer is comprehensively studied via a combination of atomic force microscopy, X-ray diffraction, transmission electron microscopy, and electrical transports. This approach enables direct integration of complex oxides with arbitrary substrates and devices and is expected to offer a faster route towards the development of low-dimensional quantum materials.
Infrared spectroscopy of H+(CO)(2) in the gas phase and in para-hydrogen matrices
(2020-08-28)
Leicht, Daniel
;
Rittgers, Brandon M.
;
Douberly, Gary E.
;
Wagner, J. Philipp
;
McDonald, David C., II
The H+(CO)(2) and D+(CO)(2) molecular ions were investigated by infrared spectroscopy in the gas phase and in para-hydrogen matrices. In the gas phase, ions were generated in a supersonic molecular beam by a pulsed electrical discharge. After extraction into a time-of-flight mass spectrometer, the ions were mass selected and probed by infrared laser photodissociation spectroscopy in the 700 cm(-1)-3500 cm(-1) region. Spectra were measured using either argon or neon tagging, as well as tagging with an excess CO molecule. In solid para-hydrogen, ions were generated by electron bombardment of a mixture of CO and hydrogen, and absorption spectra were recorded in the 400 cm(-1)-4000 cm(-1) region with a Fourier-transform infrared spectrometer. A comparison of the measured spectra with the predictions of anharmonic theory at the CCSD(T)/ANO1 level suggests that the predominant isomers formed by either argon tagging or para-hydrogen isolation are higher lying (+7.8 kcal mol(-1)), less symmetric isomers, and not the global minimum proton-bound dimer. Changing the formation environment or tagging strategy produces other non-centrosymmetric structures, but there is no spectroscopic evidence for the centrosymmetric proton-bound dimer. The formation of higher energy isomers may be caused by a kinetic effect, such as the binding of X (=Ar, Ne, or H-2) to H+(CO) prior to the formation of X H+(CO)(2). Regardless, there is a strong tendency to produce non-centrosymmetric structures in which HCO+ remains an intact core ion.
【109年職員教育訓練課程4】台灣社會創新發展趨勢
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
日期：9月10日（四）時間：15:00-17:00 地點：守仁樓膺...
【導師輔導知能研討工作坊】
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
為培養學生健全品格，建立良好師生互動，學務處將舉辦一年一度..
「陽明數位牙材」3D列印假牙材料，再獲美國FDA核可
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
繼今年5月獲得3D列印臨時假牙材料的FDA核可，陽明數位牙材公司8月18日又有一項產品──BB base 3D列印全口假牙基底材料，獲美國食
陽明附醫深耕社區，十字軍第九年訪視宜蘭長者
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
陽明十字軍與陽明大學附設醫院今年第九度共同舉辦「健康活樂宜蘭市」暑期訪視活動，從8月12日至16日共五天，至宜蘭市中山里、西門
【109學年度新生入學典禮暨入學輔導】
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
109學年度新生入學典禮暨入學輔導，將於9月7日至9月8日舉辦，熱烈歡迎新生！典禮中將安排相關課程，希望新生認識校園及環境...
【實驗動物福祉和動物權】
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
有關動物保護法、實驗動物相關福祉和動物權之介紹。
Universal nonequilibrium I-V curve near the two-channel Kondo-Luttinger quantum critical point
(2020-08-28)
Lin, C-Y
;
Chang, Y-Y
;
Rylands, C.
;
Andrei, N.
;
Chung, C-H
Over recent decades, a growing number of systems, many of them quantum critical, have been shown to exhibit non-Fermi-liquid behavior, but a full analytic understanding of such systems out of equilibrium is still lacking. In this paper, we provide a distinct example with broad applications in correlated mesoscopic systems to address this issue-a two-channel Kondo-Luttinger model where a Kondo impurity couples to two voltage-biased interacting electron leads, experimentally realizable in a dissipative quantum dot. Therein, an exotic quantum phase transition has been known to exist since the 1990s from the one-channel to two-channel Kondo ground states by enhancing electron interactions in the leads, but a controlled analytic approach to this quantum critical point has not yet been established due to the breakdown of weak-coupling perturbation theory near this strong-coupling critical point. We present a controlled method to this long-standing problem by mapping the system in the strong-coupling regime to an effective spin-boson-fermion Hamiltonian. Another type of non-Fermi-liquid quantum critical point is discovered with a distinct logarithmic-in-temperature and -voltage dependence in transport. We further obtain an analytical form for the universal differential conductance out of equilibrium near the transition. Our approach can be further generalized to study nonequilibrium physics of other strong-coupling low-dimensional non-Fermi-liquid fixed points. The relevance of our results for recent experiments is discussed.
Piezoresponse force microscopy imaging and its correlation with cantilever spring constant and frequency
(2020-08-28)
Solis Canto, O.
;
Murillo-Bracamontes, E. A.
;
Gervacio-Arciniega, J. J.
;
Toledo-Solano, M.
;
Torres-Miranda, G.
Single-frequency piezoresponse force microscopy (PFM) images of a BiFeO3/DyScO3(110) thin film, obtained with long (k(c)=0.82N/m) and short (k(c)=7.64N/m) cantilevers, were analyzed as a function of the applied voltage frequency. For long cantilevers, the electrostatic and electrostrictive contributions were identified. These contributions were reduced with a frequency near the second mode of the contact resonance; while for short cantilevers, the first mode was necessary. A method for domain structure analyses, to discriminate a ferroelectric behavior from a non-ferroelectric, through the optimization of PFM images, is also described. The analysis can be extended to cantilevers with different spring constants and ferroelectric materials.
總是「延」不由衷，「延」習如何攻略？ ──與拖延罪惡感共處三部曲
(國立陽明大學, 2020-08-28)
梅瑋纮
;
蔡宗祐
;
陽明電子報編輯小組
【看見你的自由步】～舞蹈擴增實境AR示範演出講座
(國立陽明大學, 2020-08-28)
陽明電子報編輯小組
《看見你的自由步》讓舞蹈與科技結合，透過擴增實境（Augmented...