標題: | Ligand and metal complex having the same |
作者: | Wang Yun-Ming Liu Gin-Chung Chen Chiao-Yun Li Teng-Wen |
公開日期: | 24-二月-2015 |
摘要: | A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal complex of the present invention is applicable to the preparation of MRI contrast agents for detecting atherosclerosis. The MRI contrast agent includes a peptide sequence specific to a matrix metalloprotease, and can be recognized by a pathological thrombocyte to target a specific site, so as to enhance the imaging contrast. |
官方說明文件#: | A61K051/00 A61K049/00 A61B005/00 A61K038/04 |
URI: | http://hdl.handle.net/11536/122816 |
專利國: | USA |
專利號碼: | 08961928 |
顯示於類別: | 專利資料 |