標題: | Stimuli-Responsive Controlled Drug Release from Magnetic-Sensitive Silica Nanospheres |
作者: | Hu, Shang-Hsiu Liu, Ting-Yu Huang, Hsin-Yang Liu, Dean-Mo Chen, San-Yuan 材料科學與工程學系 Department of Materials Science and Engineering |
關鍵字: | Controlled Drug Release;Magnetic;Nanospheres |
公開日期: | 1-二月-2009 |
摘要: | A novel method for control burst releasing of drug via a high frequency magnetic field (HFMF) from magnetic-sensitive silica nanospheres was developed. The nanospheres were synthesized by a combination of emulsion and sol-gel process with the particles controlled at about 80 nm in diameter. Under repeated exposures to the high frequency magnetic stimulus, the drug release behaviors showed reproducible slow-to-burst profiles while consecutively applying the magnetic stimulus at 10-min switching time and the release profile restored immediately when the stimulus was removed. By taking this non-contact control-burst method, the magnetic silica nanospheres can be designed to treat the cancer therapy and urgent physiological needs. |
URI: | http://dx.doi.org/10.1166/jnn.2009.C042 http://hdl.handle.net/11536/12745 |
ISSN: | 1533-4880 |
DOI: | 10.1166/jnn.2009.C042 |
期刊: | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY |
Volume: | 9 |
Issue: | 2 |
起始頁: | 866 |
結束頁: | 870 |
顯示於類別: | 會議論文 |