標題: | A CMOS-Based Phototransistor for High-Sensitivity Biochemical Detection Using Absorption Photometry |
作者: | Chang, Yu-Wei Tai, Yu-Ting Huang, Yang-Tung Yang, Yuh-Shyong 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics |
關鍵字: | Biomedical transducers;medical diagnosis;photodetectors;phototransistors |
公開日期: | 2008 |
摘要: | This paper proposes a high-sensitivity biosensing system on the basis of absorption photometry and a phototransistor. Manufactured in a standard 0.35-mu m CMOS technology, the phototransistor exhibits a responsivity higher than 1000 A/W for 650-nm light. The TMB/H(2)O(2)/HRP method is chosen as a useful platform to determine the amount of various interesting targets. For the biochemical detection, a sample volume of only 10 mu l is required to be dropped on the slide above the phototransistor. Experimental results demonstrate that a high sensitivity of 2.5 mu A/pM is achieved, and the minimum HRP concentration successfully detected is 2.7 pM. This detection limit is three orders of magnitude better than that of a reported silicon biosensor. |
URI: | http://hdl.handle.net/11536/31342 |
ISBN: | 978-1-4244-2176-3 |
期刊: | PROCEEDINGS OF THE THIRD INTERNATIONAL CONFERENCE ON SENSING TECHNOLOGY |
起始頁: | 82 |
結束頁: | 85 |
顯示於類別: | 會議論文 |