Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor
| dc.citation.volume | 8351 | en_US |
| dc.contributor.author | Huang, Chi-Chieh | en_US |
| dc.contributor.author | Hsu, Hsin-Feng | en_US |
| dc.contributor.author | Chen, Sz-Hau | en_US |
| dc.contributor.author | Tsai, Kun-Yu | en_US |
| dc.contributor.author | Huang, Yang-Tung | en_US |
| dc.contributor.author | Lin, Chih-Sheng | en_US |
| dc.contributor.author | Hsu, Shih-Hsin | en_US |
| dc.contributor.department | 電子工程學系及電子研究所 | zh_TW |
| dc.contributor.department | Department of Electronics Engineering and Institute of Electronics | en_US |
| dc.date.accessioned | 2014-12-08T15:23:05Z | |
| dc.date.available | 2014-12-08T15:23:05Z | |
| dc.date.issued | 2012 | en_US |
| dc.description.abstract | In this paper, real-time characterization of alpha-thrombin binding to single-strand DNA (ssDNA) aptamers by novel Si-based waveguide SPR biosensors has been investigated. The gold nanoparticles (AuNPs) modified with anti-thrombin antibodies were employed to bind with alpha-thrombin via strong antibody/antigen affinity for SPR signal amplification. The detection limit of 1 pM for alpha-thrombin detection was achieved. | en_US |
| dc.identifier.doi | 83512R | en_US |
| dc.identifier.isbn | 978-0-8194-9027-8 | en_US |
| dc.identifier.issn | 0277-786X | en_US |
| dc.identifier.journal | THIRD ASIA PACIFIC OPTICAL SENSORS CONFERENCE | en_US |
| dc.identifier.uri | http://dx.doi.org/83512R | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/16228 | |
| dc.identifier.wosnumber | WOS:000304348500095 | |
| dc.language.iso | en_US | en_US |
| dc.subject | SPR | en_US |
| dc.subject | surface plasmon resonance | en_US |
| dc.subject | sensor | en_US |
| dc.title | Real-time Detection of alpha-Thrombin Binding to Single-Strand DNA Aptamers by a Highly Sensitive Si-Based Waveguide SPR Biosensor | en_US |
| dc.type | Proceedings Paper | en_US |