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孫仲銘

孫仲銘 Sun, Chung-Ming

電子郵件／E-mail：cmsun@mail.nctu.edu.tw

服務單位／Department：理學院 ／ 應用化學系

著作期間／Publish Period：1970-01-01 - 2014-08-01

著作統計／Statistics

Article（67）
Others（2）
Patents（2）
Plan（21）
Thesis（28）

Article

序號
No.		 標題
Title		 著作日期
Date
1 Rapid Two-Step Synthesis of Benzimidazo[1 \',2 \':1,5]-pyrrolo[2,3-c]isoquinolines by a Three-Component Coupling Reaction 2014-08-01
2 Regioselective Piperidine-Catalyzed Tandem Imination-Isocyanate Annulation to Fused Tricyclic Triazines
 2014-05-01
3 One-Pot Synthesis of Triazoloquinazolinones via Copper-Catalyzed Tandem Click and Intramolecular C-H Amidation 2014-04-14
4 Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
 2014-01-15
5 Palladium-catalyzed regioselective synthesis of 2(2 '-biphenyl)benzimidazoles through C-H activation
 2013-11-01
6 Diastereoselective Synthesis of Bridged Polycyclic Alkaloids via Tandem Acylation/Intramolecular Diels-Alder Reaction
 2013-10-04
7 One-Pot, Two-Step Synthesis of Imidazo[1,2-a]benzimidazoles via A Multicomponent [4+1] Cycloaddition Reaction
 2013-10-01
8 Sequential [3+2] and [4+2] Cycloadditions for Stereoselective Synthesis of a Novel Polyheterocyclic Scaffold
 2013-07-01
9 Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation
 2013-06-01
10 Rapid synthesis of novel isoindolo[1,2-a] quinazoline on ionic liquid support under microwave irradiation 2013-06-01
11 One pot three component reaction for the rapid synthesis of pyrrolo[1,2-a]benzimidazoles
 2013-05-01
12 Enantioselective synthesis of (-)-(R) Silodosin by ultrasound-assisted diastereomeric crystallization
 2013-04-01
13 A Telescoping Synthesis of Chimeric Polyheterocycles through a Piperidine-Mediated Multicomponent Reaction
 2013-04-01
14 Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine
 2013-02-06
15 Multistep divergent synthesis of benzimidazole linked benzoxazole/benzothiazole via copper catalyzed domino annulation
 2013-01-01
16 A concise synthesis of 2-(2-aminothiophene)-benzimidazoles by one-pot multicomponent reaction
 2013-01-01
17 Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs
 2013-01-01
18 Ionic liquid supported synthesis of tricyclic pyrimido [1,2-a]benzimidazoles by a telescoped Michael/hetero annulation strategy
 2013-01-01
19 Qualitative analysis of the fluorophosphonate-based chemical probes using the serine hydrolases from mouse liver and poly-3-hydroxybutyrate depolymerase (PhaZ) from Bacillus thuringiensis
 2012-11-01
20 Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas
 2012-08-01
21 Novel ionic liquid supported-multicomponent reaction toward chimeric bis-heterocycles
 2012-08-01
22 A highly selective fluorescent chemosensor for Ag+ based on calix[4]arene with lower-rim proximal triazolylpyrenes
 2012-08-01
23 Light Fluorous-Tagged Traceless One-Pot Synthesis of Benzimidazoles Facilitated by Microwave Irradiation 2012-06-01
24 Design and Synthesis of New Biprivileged Molecular Scaffolds: Indolo-Fused Benzodiazepinyl/quinoxalinyl benzimidazoles
 2012-06-01
25 Traceless polymer-supported divergent synthesis of quinoxalinones by microwave irradiation 2012-05-06
26 Ionic liquid-supported synthesis of dihydroquinazolines and tetrahydroquinazolines under microwave irradiation
 2012-05-01
27 Microwave-Assisted Linear Approach Toward Highly Substituted Benzo[d]oxazol-5-yl-1H-benzo[d]imidazole on Ionic Liquid Support
 2012-02-01
28 Microwave-Enhanced Efficient Regioselective Synthesis of 1,3,4-Trisubstituted 2-Mercaptoimidazoles on a Soluble Support 2012-01-01
29 A specific and ratiometric chemosensor for Hg(2+) based on triazole coupled ortho-methoxyphenylazocalix[4]arene 2011-10-21
30 Base-Catalyzed Povarov Reaction: An Unusual [1,3] Sigmatropic Rearrangement to Dihydropyrimidobenzimidazoles
 2011-10-07
31 Microwave-Assisted Tandem Transformation on an Ionic-Liquid Support: Efficient Synthesis of Pyrrolo/Pyridobenzimidazolones and Isoindolinone-Fused Benzimidazoles
 2011-09-05
32 Novel approach towards 2-substituted aminobenzimidazoles on imidazolium ion tag under focused microwave irradiation
 2011-08-26
33 Divergent Synthesis of Unsymmetrical Annulated Biheterocyclic Compound Libraries: Benzimidazole Linked Indolo-benzodiazepines/quinoxaline
 2011-07-01
34 Regioselective, Unconventional Pictet-Spengler Cyclization Strategy Toward the Synthesis of Benzimidazole-Linked Imidazoquinoxalines on a Soluble Polymer Support
 2011-06-06
35 Ionic liquid supported multistep divergent synthesis of benzimidazole linked pyrrolo-/pyrido-/isoindolo-benzimidazolones
 2011-06-01
36 Traceless synthesis of diketopiperazine fused tetrahydro-beta-carbolines on soluble polymer support
 2011-05-01
37 Microwave assisted straightforward synthetic method for benzimidazole linked quinoxalinones on soluble polymer support
 2011-03-18
38 Microwave Promoted Simple, Efficient and Regioselective Synthesis of Trisubstituted Imidazo[1,2-a]benzimidazoles on Soluble Support
 2011-03-01
39 Scaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiation
 2011-02-01
40 Soluble polymer supported divergent synthesis of tetracyclic benzene-fused pyrazino/diazepino indoles: an advanced synthetic approach to bioactive scaffolds
 2011-01-01
41 Polymer supported synthesis of novel benzoxazole linked benzimidazoles under microwave conditions: In vitro evaluation of VEGFR-3 kinase inhibition activity
 2011-01-01
42 Novel approach towards the synthesis of skeletally diverse benzimidazole-pyrrolo[1,2-a]quinoxaline by S(N)Ar/Pictet-Spengler reaction under focused microwave irradiation 2011-01-01
43 SIMPLE AND EFFICIENT ONE POT SYNTHETIC PROTOCOL TO CONSTRUCT MORPHOLIN-2-ONES 2010-12-31
44 Multidisciplinary Synthetic Approach for Rapid Combinatorial Library Synthesis of Triaza-Fluorenes
 2010-09-01
45 Multistep Microwave-Assisted Divergent Synthesis of Indolo-Fused Pyrazino-/Diazepinoquinoxalinones on PEG Support
 2010-05-21
46 Synthesis and Preclinical Evaluations of 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-one Monosodium Phosphate (CHM-1-P-Na) as a Potent Antitumor Agent
 2010-02-25
47 Novel cyclization of bis-Boc-guanidines: expeditive traceless synthesis of 1,3,5-oxadiazinones under microwave conditions
 2010-01-01
48 Convergent Solution Phase Synthesis of Chimeric Oligonucleotides by a 2+2 and 3+3 Phosphoramidite Strategy 2010-01-01
49 Unusual Anisotropic Effects from 1,3-Dipolar Cycloadducts of 4-Azidomethyl Coumarins 2010-01-01
50 Traceless Synthesis of Hydantoin Fused Tetrahydro-beta-carboline on Ionic Liquid Support in Green Media
 2009-11-05
51 Diversity-Oriented Synthesis of Angular Bis-benzimidazole Derivatives under Microwave Irradiation
 2009-11-01
52 Enantioselective Synthesis of Benzimidazolyl Quinoxalinones on Soluble Polymer Support Using Focused Microwave Irradiation
 2009-03-01
53 Microwave-Assisted Synthesis of Tetracyclic 2,5-Diketopiperazines on a Soluble Polymer Support: A Structural Analogue of Tadalafil 2009-01-01
54 Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins
 2008-10-01
55 5-phenylpyridazinones - A serendipitous route from coumarins
 2008-07-07
56 Synthesis of structurally diverse benzimidazolyl benzimidazolones by application of soluble polymer support
 2008-06-30
57 Parallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support
 2008-05-01
58 Microwave-assisted traceless synthesis of hydantion-fused beta-carboline scaffold
 2007-11-26
59 Fluorous and traceless synthesis of substituted indole alkaloids
 2007-11-01
60 Scaffold-directed traceless synthesis of tetrahydro-beta-carbolinehydantoins
 2007-07-01
61 Microwave-assisted and traceless synthesis of imidazoquinoxalinones
 2006-07-10
62 Parallel synthesis of amino bis-benzimidazoles by multistep microwave irradiation
 2006-04-10
63 Traceless and stereoselective synthesis of tetrahydro-beta-carbolinethiohydantoins by microwave irradiation
 2006-03-01
64 One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
 2005-11-01
65 Synthesis and biological evaluation of novel angularly fused polycyclic coumarins
 2005-08-01
66 Microwave-assisted benzimidazole cyclization by bismuth chloride
 2005-05-17
67 Microwave-assisted synthesis of highly functionalized guanidines on soluble polymer support
 1970-01-01

Others

序號
No.		 標題
Title		 著作日期
Date
1 A proteomic approach to study molecular mechanisms of andrographolide-mediated degradation of Src oncoproteins. 2013-04-15
2 Recent advances in coumarins and 1-azacoumarins as versatile biodynamic agents 2006-01-01

Patents

序號
No.		 標題
Title		 著作日期
Date
1 Bicyclic Heteroaryl Compounds
 2011-04-07
2 INDAZOLE COMPOUNDS
 2008-06-05

Plan

序號
No.		 標題
Title		 著作日期
Date
1 研究有機活性分子的碳氫鍵直接官能團化反應 2014
2 從現有市場藥品之代謝物發展新型NMDA 受體調節劑---(子計畫二)合成與設計新型NMDA 受體調控劑治療精神分裂相關疾病 2014
3 組蛋白甲基轉移脢G9a抑制劑之發展---(總計畫與子計畫二)合成與設計組蛋白甲基轉移脢G9a抑制劑調控腫瘤幹細胞的生長(III) 2013
4 研究有機活性分子的碳氫鍵直接官能團化反應 2013
5 研究有機活性分子的碳氫鍵直接官能團化反應 2012
6 組蛋白甲基轉移脢G9a抑制劑之發展---(總計畫與子計畫二)合成與設計組蛋白甲基轉移脢G9a抑制劑調控腫瘤幹細胞的生長(II) 2012
7 應用氟相標籤合成具有光學和生物活性的有機小分子庫 2011
8 組蛋白甲基轉移脢抑制劑之發展---(總計畫與子計畫二)合成與設計組蛋白甲基轉移脢抑制劑調控腫瘤幹細胞的生長(I) 2011
9 抑制腫瘤細胞轉移和成長的分子靶向性先導藥物研發(Ⅳ)---先導抗癌標靶藥物nstpbp253和355的最佳化設計和新穎奈米化抑制腫瘤藥物傳輸配方 2010
10 應用氟相標籤合成具有光學和生物活性的有機小分子庫 2010
11 抑制血管內皮細胞生長因子作用的先導藥物最佳化和新穎藥物傳輸配方設計 2009
12 應用氟相標籤合成具有光學和生物活性的有機小分子庫 2009
13 快速平行合成多岐異性的抗腫瘤新藥分子庫 2008
14 抑制腫瘤細胞轉移和成長的分子靶向性先導藥物研發---雜環類先導藥物的演化和多樣式的設計合成(II) 2008
15 快速平行合成多岐異性的抗腫瘤新藥分子庫 2008
16 快速平行合成多岐異性的抗腫瘤新藥分子庫 2007
17 抑制腫瘤細胞轉移和成長的分子靶向性先導藥物研發---雜環類先導藥物的演化和多樣式的設計合成(總計畫暨子計畫一) 2007
18 抑制淋巴管增生的先導藥物最佳化 2006
19 快速平行合成多岐異性的抗腫瘤新藥分子庫 2006
20 多樣性分子庫合成與設計新生血管生長因子抑制劑 2005
21 微波組合式藥物分子庫在化學基因體學上的應用(III) 2005

Thesis

序號
No.		 標題
Title		 著作日期
Date
1 以先導化合物為骨架設計合成雜環化合物分子庫,利用金屬輔助合成多樣性苯并咪唑衍生物 2013
2 新藥研發及藥物合成與新合成方法的開發及其研究 2013
3 一鍋化多米諾骨牌式轉換合成骨架多樣性異環小分子 2013
4 利用胺基酸酯設計合成喹唑啉衍生物 ; 利用銅催化於有氧環境進行環化-酮化反應合成咪唑併[1,2-a]苯併咪唑衍生物 2013
5 金屬催化合成以及合成硫、硒異種原子之雜環分子庫 2013
6 合成設計多種pyrimidopyrroloquinoxalinediones衍生物,利用金屬合成苯併咪唑衍生物分子庫 2013
7 以2 - 氰甲基苯并咪唑化合物為起始物設計合成大量變異性有機小分子 2011
8 合成設計多種骨架之雜環小分子化合物分子庫 2011
9 利用金屬催化合成多種骨架之雜環小分子分子庫 2011
10 微波輔助高效率合成異喹啉酚及喹口咢啉二酮的衍生物
 2011
11 合成構思結構多樣性之雜環有機小分子分子庫 2011
12 研發新型RAD 51 與 NF-kB抑制劑：IBR2衍生物以及氨基呋喃鍵結苯并咪唑與合成磷酰吡唑鍵結苯并咪唑 2011
13 研究對合成熔融，線性和角雜環可溶性小分子庫的支持，新的癌症治療
 2010
14 微波輔助切除載體合成新穎含硒類的吲哚生物鹼分子庫及合成具異原子氮、氧、硫、硒的苯駢咪唑衍生物 2010
15 (一) 位向選擇性調控合成苯并噻二嗪分子庫。(二) 微波輔助與離子液體載體並環化切除合成咪唑苯二氮平分子庫。 2010
16 none
 2009
17 合成設計多種苯並咪唑主架構的雜環化合物分子庫進行標靶先導藥物的研發 2009
18 合成具氧、硫變異性四氫異喹啉及氧、硫、硒變異性四氫-β-咔啉之反應機構探討 2009
19 以雙胺基化合物為起始物設計合成大量變異性苯並咪咄衍生物 2009
20 (一) 核苷酸寡聚物之合成 (二) 微波輔助液相合成Tetrahydro-β-carboline hydantoins及Benzoimidazole[1,2-a]quinoxalines 2008
21 微波加速液相載體進行多組成分(4?+2?)-Cycloaddition 反應合成Benzimidazoles 分子庫 2008
22 利用微波輔助與液相高分子載體合成Benzodiazepine與Quinoxaline分子庫 2008
23 (一) 微波加速氟相載體進行一鍋化反應合成Benzimidazole分子庫 (二) 高分子載體合成Imidazoquinoxalinone衍生物 (三) 溶液相及高分子載體進行分子內Diels-Alder反應合成[6,5,6,5,6] 環吲哚生物鹼分子庫 2007
24 （一）利用微波與液相高分子載體與平行式合成的觀念合成出具有抗癌活性UK-1相似衍生物Bis（benzimidazoles）分子庫（二）利用微波合成與液相高分子載體結合四單元縮合反應快速合成出Quinoxalinone分子庫（三）於溶液相條件下合成出具有核醣核酸干擾潛力的核苷酸片段 2007
25 利用微波輔助與液相高分子載體(Ⅰ)一鍋化3-成分反應合成4H-pyridimido[2,1-b]benzoles分子庫與9H-Benzo[d]imidazo[1,2-a]imidazole分子庫(Ⅱ)合成2,4-dihydrobenzo[4,5]imidazo[1,2-b][1,2,4]thiadiazole與3-Amino-9H-benzo[d]imidazo[1,2-a]imidazole分子庫 2007
26 (1)液相組合式化學平行合成Bis(benzimidazole)、beta-Carboline Benzodiazepine及Quinoxalinone衍生物分子庫 (2) 合成穿心蓮內酯衍生物 2007
27 使用可溶性高分子載體合成Benzimidazole及Benzimidazoquinazoline衍生物分子庫 2007
28 (一) 高分子載體合成Bisbenzimidazole、Benzodiazepine以及Quinoxaline衍生物分子庫 (二) 合成蛋白質活性標示探針分子 2007
理學院