Browsing by Issue Date, starting with "2012-12-26"

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Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar-Fibroblast Growth Factor-1 Interaction
(2012-12-26)
Hu, Yu-Peng
;
Zhong, Yong-Qing
;
Chen, Zhi-Geng
;
Chen, Chun-Yen
;
Shi, Zhonghao
Several biological processes involve glycans, yet understanding their ligand specificities is impeded by their inherent diversity and difficult acquisition. Generating broad synthetic sugar libraries for bioevaluations is a powerful tool in unraveling glycan structural information. In the case of the widely distributed heparan sulfate (HS), however, the 48 theoretical possibilities for its repeating disaccharide call for synthetic approaches that should minimize the effort in an undoubtedly huge undertaking. Here we employed a divergent strategy to afford all 48 HS-based disaccharides from just two orthogonally protected disaccharide precursors. Different combinations and sequence of transformation steps were applied with many downstream intermediates leading up to multiple target products. With the full disaccharide library in hand, affinity screening with fibroblast growth factor-1 (FGF-1) revealed that four of the synthetic sugars bind to FGF-1. The molecular details of the interaction were further clarified through X-ray analysis of the sugar-protein cocrystals. The capability of comprehensive sugar libraries in providing key insights in glycan-ligand interaction is, thus, highlighted.
Numerical study of viscosity and inertial effects on tank-treading and tumbling motions of vesicles under shear flow
(2012-12-26)
Kim, Yongsam
;
Lai, Ming-Chih
;
應用數學系
;
數學建模與科學計算所(含中心)
;
Department of Applied Mathematics
An inextensible vesicle under shear flow experiences a tank-treading motion on its membrane if the viscosity contrast between the interior and exterior fluids is small. Above a critical threshold of viscosity contrast, the vesicle undergoes a tumbling bifurcation. In this paper, we extend our previous work [Kim and Lai, J. Comput. Phys. 229, 4840 (2010)] to the case of different viscosity and investigate the transition between the tank-treading and tumbling motions in detail. The present numerical results are in a good agreement with other numerical and theoretical studies qualitatively. In addition, we study the inertial effect on this transition and find that the inertial effect might inhibit the tumbling motion in favor of the tank-treading motion, which is observed recently in the literature. The critical viscosity contrast for the transition to the tumbling motion usually increases as the reduced area increases in the Stokes regime. However, we surprisingly observe that the critical viscosity contrast decreases as the reduced area increases to some point in the flow of slightly higher Reynolds number. Our numerical result also shows that the inertial effect has stronger inhibition to tumbling motion when the reduced area is small. DOI: 10.1103/PhysRevE.86.066321
蘇東坡詩詞中的人生體驗
(2012-12-26)
呂正惠
;
開放教育推動中心
;
Open Education Office
課程首頁本課程是由交通大學新文藝復興閱讀計畫提供。 96 年 8 月當各大學紛紛摩拳擦掌準備迎接新生的同時，交通大學校長吳重雨則因為一則來自於七月份泰晤士報，有關於英國首相布朗公布其夏日讀書清單的新聞中，看到了他對知識的尊重。在這同時，吳重雨校長也思考著，要如何為學生準備追求知識的環境和激發他們對知識的尊重與喜愛。台積電張忠謀董事長曾陳述他 18 歲進入哈佛那一年，博覽文史哲理工經典群籍，至此奠定了他求知的基礎，並借海明威名言，將其改為「哈佛這一年為人生可帶走的盛宴。」吳重雨校長以張董事長的學習為借鏡，認為學生固然能藉由自我閱讀的方式學習到豐沛的知識，但透過名人、大師親臨現場地介紹經典書籍，更能加深學子們對於書籍的認識與興趣，這也是「新文藝復興閱讀計劃」 ( 以下簡稱 : 「經典名著選讀」 ) 活動展開籌劃的緣由。於是，吳重雨校長便積極敦請「交大通識教育委員會」，接手籌備本計劃的相關活動，而該中心也成為實際施行本計畫的策動、開課以及認證單位。至此，期許交大學子藉由閱讀、聽講來提昇人文素養、開拓視野的「新文藝復興閱讀計劃」，就此展開。
METHOD FOR KEY GENERATION, MEMBER AUTHENTICATION, AND COMMUNICATION SECURITY IN DYNAMIC GROUP
(2012-12-27)
TSENG Chien-Chao
;
Ho Tzu-Hsin
The present invention provides a method for keys generation, member authentication and communication security in a dynamic group, which comprises steps: assigning each member an identification vector containing common group identification vector elements and an individual identification vector element, and generating an authentication vector and an access control vector for each member according to the identification vector; using the identification vector elements to generate public key elements and establish an authentication public key and an access control public key; and using a polynomial and the identification vector to generate a private key. The present invention uses these public keys and private keys, which are generated from the identification vectors, to implement serverless member authentication and data access control, whereby is protected privacy of members and promoted security of communication.
Terahertz optical properties of multilayer graphene: Experimental observation of strong dependence on stacking arrangements and misorientation angles
(2012-12-27)
Lin, I-Tan
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Liu, Jia-Ming
;
Shi, Kai-Yao
;
Tseng, Pei-Shan
;
Wu, Kuang-Hsiung
The optical conductivity of monolayer and multilayer graphene in the terahertz spectral region is experimentally measured using terahertz time-domain spectroscopy. The stacking arrangement and the misorientation angle of each sample are determined by Raman spectroscopy. The chemical potential of each sample is measured using ultrafast midinfrared pump-probe spectroscopy to be 63 or 64 meV for all samples. The intraband scattering rate can be obtained by fitting the measured data with theoretical models. Other physical parameters, including carrier density, dc conductivity, and carrier mobility, of each sample can also be deduced from the theoretical fitting. The fitting results show the existence of misoriented or AA-stacked layers with an interaction energy of alpha(1) = 217 meV in our multilayer samples. Here we show that the scattering rate strongly depends on the stacking arrangement of the sample. High scattering rates and high optical conductivity are associated with AA-stacked samples, while lower ones are associated with misoriented multilayer graphene. This implies that the THz optoelectronic properties of multilayer graphene can be tuned by purposefully misorienting layers or employing different stacking schemes. DOI: 10.1103/PhysRevB.86.235446 PACS number(s): 78.67.Wj, 61.48.Gh, 72.80.Vp, 73.50.Mx
DECENTRALIZED STRUCTURED PEER-TO-PEER NETWORK AND LOAD BALANCING METHODS THEREOF
(2012-12-27)
Hsu Chung-Yuan
;
Wang Kuochen
;
Shih Hung-Cheng
An approach is provided for reassigning and sharing loads to peers with a same identity, which is based on a threshold. The peers are configured to store indexes of a key and to share the same loading (i.e., indexes) of the key to the peers with same secondary identities in different zones. The secondary identity is derived and has a modulo relationship with a first identity of the peer. The threshold indicates maximum number of indexes stored in each peer. Therefore, the loading are distributed evenly to peers in different zones, which achieves load balance to a decentralized structured peer-to-peer network.
SOLAR CELL AND FABRICATION METHOD THEREOF
(2012-12-27)
Meng Hsin-Fei
;
Zan Hsiao-Wen
;
Horng Sheng-Fu
;
Chao Yu-Chiang
;
Lin Yuan-Pai
A solar cell is provided that an extremely thin light absorber is formed between a n-type semiconductor layer and a p-type semiconductor layer such that the light absorber is used to absorb solar energy, while the p-type semiconductor layer may not absorb light. After separation of electrons and holes, the carriers will not recombine during the conduction, in order to avoid energy loss.
Melting behavior of Ag-14 cluster: An order parameter by instantaneous normal modes
(2012-12-28)
Tang, Ping-Han
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Wu, Ten-Ming
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Hsu, P. J.
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Lai, S. K.
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物理研究所
This paper studies the melting behavior of Ag-14 cluster employing the instantaneous normal mode (INM) analysis that was previously developed for bimetallic cluster Ag17Cu2. The isothermal Brownian-type molecular dynamics simulation is used to generate atom configurations of Ag-14 at different temperatures up to 1500 K. At each temperature, these atomic configurations are then analyzed by the INM technique. To delve into the melting behavior of Ag-14 cluster which differs from Ag17Cu2 by the occurrence of an anomalous prepeak in the specific heat curve in addition to the typical principal peak, we appeal to examining the order parameter tau(T) defined in the context of the INM method. Two general approaches are proposed to calculate tau(T). In one, tau(T) is defined in terms of the INM vibrational density of states; in another, tau(T) is defined considering the cluster as a rigid body with its rotational motions described by three orthogonal eigenvectors. Our results for Ag-14 by these two methods indicate the mutual agreement of tau(T) calculated and also the consistent interpretation of the melting behavior with the specific heat data. The order parameter tau(T) provides in addition an insightful interpretation between the melting of clusters and the concept of broken symmetry which has been found successful in studies of the melting transition of bulk systems. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4772096]
Time-frequency resolved analysis of a nanosecond supercontinuum source dedicated to multiplex CARS application
(2012-12-31)
De Angelis, Annalisa
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Labruyere, Alexis
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Couderc, Vincent
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Leproux, Philippe
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Tonello, Alessandro
In this paper, we describe and investigate the properties of a broadband source designed from a nanosecond microchip laser operating at high repetition rate and dedicated to multiplex-CARS application. We demonstrate that a strong reshaping of the initial pulse profile drastically affects the Stokes wave and therefore represents an important limitation in CARS experiment. In particular, we emphasize the saturation effect of the peak power of the Stokes wave resulting from supercontinuum generation. However, we show that this type of compact system can be particularly suitable for achieving CARS measurement. (C) 2012 Optical Society of America
藥物-蛋白質網路與結構系統生物探討癌症與神經系統失調---藥物-蛋白質同源網路探討藥物開發與結合機制(總計畫及子計畫1)(III)
(2013)
楊進木
;
YANG JINN-MOON
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國立交通大學生物科技學系（所）
PMR: Personalized Mobile Restaurant System
(2013)
Daraghmi, Eman Yasser
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Yuan, Shyan-Ming
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資訊工程學系
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Department of Computer Science
Personalized mobile applications involve deploying the existing technologies to accommodate the differences between individuals. The existing applications have undertaken with the price and the location factors in mind. They show the same results regardless the personal special needs of consumers. The realization of the next generation of personalized systems will be a challenging task. For our research purpose, the personal special needs are defined as: (Religions, Cultures, Allergies, Health Condition, Diet, Preferences and Dislikes) needs that affect many aspects of a consumer life. In general there is no shortage of the restaurant apps available in the App_Store, However, many of these apps are based on regular factors such as price and location. They are not a great choice for consumers with personal special needs. This paper proposes a novel "Personalized Mobile Restaurant" PMR system. To meet the strict needs of consumers; a requirement driven design approach was followed. The proposed system was tested successfully and promising results were obtained.
Batteryless 275mV Startup Single-Cell Photovoltaic Energy Harvesting System for Alleviating Shading Effect
(2013-01-01)
Huang, Chao-Jen
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Su, Yi-Ping
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Chen, Ke-Horng
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Huang, Li-Ren
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Chu, Fang-Chih
without any batteries, a low input voltage converter is presented for a single-cell (SC) photovoltaic (PV) energy harvesting to alleviate the energy degradation due to shading effect. The proposed low voltage startup (LVS) circuit with low input voltage of 275 mV and less than 840 ms startup time achieves high voltage conversion ratio to supply a high accuracy bandgap reference. Experimental results show the maximum power throughput is up to 6 mW and the quiescent power is less than 650 mu W with integrated two buck-boost converters and two boost converters. The peak efficiency of the boost converter can be up to 75.8% for ultra-low voltage hearing aid systems.
An Online Recursive ICA Based Real-time Multi-channel EEG System on Chip Design with Automatic Eye Blink Artifact Rejection
(2013)
Liao, Jui-Chieh
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Shih, Wei-Yeh
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Huang, Kuan-Ju
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Fang, Wai-Chi
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電子工程學系及電子研究所
This paper presents an online recursive ICA (ORICA) based real-time multi-channel EEG system on chip design with automatic eye blink artifact rejection. Since EEG signals are very feeble, they are easy to be contaminated by artifacts. Among all artifacts, eye blink artifact dose the most significant harm to EEG signals. For acquiring artifact free EEG signals, ICA is a popular method for artifacts extraction. After extraction of ICA, eye blink artifacts are rejected to improve the reliability of EEG applications such as brain computer interfaces (BCIs). To promote the feasibility and convenience of BCIs, a real-time ICA algorithm, ORICA, is adopted in this system. With ORICA, the system immediately finishes each ICA result after each sample time. After each ICA result is generated, the automatic eye blink artifact rejection and inverse ICA are performed to acquire eye blink artifact free EEG signals in real-time. For system portability and high integration, a front-end interface of commercial IC, ADS1298 provided by TI, and Bluetooth interface, UART, are implemented. The system is designed used TSMC 90nm CMOS technology with 8 channels EEG processing in 128 Hz sample rate of raw data and consumes 8.56 mW at 50 MHz clock rate. The design methods of the proposed EEG system are provided in this paper. The performance and processing results of the system are also shown to reach 0.2532 s latency after each EEG sample time.
價格限制市場之選擇權定價模型與避險策略分析
(2013)
郭家豪
;
Guo Jia Hau
;
國立交通大學財務金融研究所
價格限制是許多金融市場常見的人為市場穩定措施，但是卻少有文獻或研究探討價格限制對個股選擇權定價及避險策略的影響。本研究將聚焦於在價格限制市場中具流動性風險的個股選擇權相關定價與避險問題的探討。藉由所求之封閉解提供的效率性，本研究將在價格限制與有限流動性的考量下，比較數種標準避險策略如delta、 delta-gamma、 delta-vega 和delta-gamma-vega 等於歐式選擇權避險績效的差異，藉此衡量價格限制與有限流動性對避險策略之影響。另外，藉由市場資料調校後的個股流動性模型參數之時間數列，將有助於了解信貸危機發生時市場流動性的變化為何。
Miniaturized Dual-Band Composite Right/Left-Handed Crossover
(2013)
Hsieh, Sheng-Yu
;
Chi, Pei-Ling
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資訊工程學系
;
Department of Computer Science
In this paper, an arbitrary dual-band and miniaturized crossover is proposed using the composite right/left-handed (CRLH) transmission structures. The proposed crossover is based on the two-section CRLH branch lines of three different characteristic impedances where one degree of design freedom can be used for implementation convenience. Combining the CRLH implementation approach with the even-and odd-mode analysis results, a simple design procedure is developed. To support our idea, a dual-band crossover operating at 0.9 GHz and 2.45 GHz was fabricated and tested. The experimental results are in good agreement with the simulated data. Compared to the reported dual-band crossovers based on the printed-circuit-board (PCB) technology, our presented crossover shows a significant size reduction by about 59% with respect to the smallest footprint found in the literature.
多視點視訊產生、傳輸與分析-子計畫三：機器學習方法於視訊編碼與處理應用
(2013)
彭文孝
;
PENG WEN-HSIAO
;
國立交通大學資訊工程學系（所）
國立交通大學資訊工程學系計畫名稱：機器學習方法於視訊編碼與處理應用計畫主持人：彭文孝（主持人）經費來源：行政院國家科學委員會關鍵字：機器學習、高效能視訊編碼、精簡描述子應用於視覺化搜尋、編碼端控制、視覺化搜尋本子計晝利用機器學習（Machine Learning)為視訊編碼與處理的應用設計高效能演算法。近年來由於大量影像及影片資料的產生與取得變得容易，以往模型導向 (Model-based)在視訊編碼與處理中存在的一些問題，可望用資料導向（Data-driven) 的方式來解決。又機器學習的方法非常適合處理資料導向的問題，因此本子計晝目標為利用機器學習的方法，針對（1)高效能視訊編碼（High Efficiency Video Coding, HEVC) 與（2)精簡描述子應用在視覺化搜尋（Compact Descriptors for Visual Search, CDVS) 兩項ISO/IEC MPEG與ITU-T VCEG正在開發的標準，為視訊編碼及處理兩項重要的多媒體應用，設計高效能之演算法。前兩年我們會參與HEVC及CDVS之標準制定會議。同時計晝（1)第一年產生大量HEVC編碼訓練資料，以機器學習方法解決分群及參數估測問題，完成HEVC編碼端快速模式決策、快速位元率控制及快速編碼工具參數產生之演算法開發；（2)第二年解決目前CDVS資料庫決定代表點的問題，使用機器學習方式分析並設計更好的代表點選擇演算法，以及使用機器學習的方法設計使用多種比對演算法之搭配方式，達到更高的比對準確率；（3)第三年基於兩項完成的標準，設計增進原有的演算法效能之方法，以及改進演算法使其適用硬體設計。由於兩項標準在兩年内就會完成，本子計晝發展之研究與演算法趕上標準的時程，將在隨之而來的應用上具有重要的影響力。
The Analysis of Nano-Patterned Sapphire Substrates-Induced Compressive Strain to Enhance Quantum-Confined Stark Effect of InGaN-Based Light-Emitting Diodes
(2013-01-01)
Chen, Po-Hsun
;
Su, Vincent
;
You, Yao-Hong
;
Lee, Ming-Lun
;
Hsieh, Cheng-Ju
This paper demonstrates that the quantum-confined stark effect of InGaN-based light-emitting diodes can be enhanced by the means of using the hexagonal nano-post patterned sapphire substrates based on the increase of the post-duty cycle.
Formation of size-tunable dandelion-like hierarchical rutile titania nanospheres for dye-sensitized solar cells
(2013)
Lan, Chi-Ming
;
Liu, Shang-En
;
Shiu, Jia-Wei
;
Hu, Jyun-Yu
;
Lin, Meng-Hung
A sol-gel method with a modified solvent comprising of three simple steps under low-temperature conditions was used to synthesize mono-disperse rutile TiO2 nanospheres with dandelion-like hierarchical morphology (DHRS) as a light-scattering layer for dye-sensitized solar cells (DSSC). 1,2-Ethanediol (ED) served as a key retardation agent in the second step at 25 degrees C to slow the hydrolysis and condensation of the TiCl4 aqueous solution prepared in the first step at 0 degrees C; the subsequent nucleation of a rutile type phase occurred homogeneously in the third step at 70 degrees C to generate the rutile TiO2 nanospheres with highly uniform sizes. The spherical sizes of DHRS were well controlled with the volume ratios of the ED-water solvent mixture in the second step, for which the DHRS of diameter 650-200 nm were produced from the solvent system containing 5-25% ED. A detailed mechanism is presented to rationalize the formation of nanospheres of uniform size in six steps: 1) hydration and hydrolysis, 2) hydrolysis and retardation, 3) hydrolysis and condensation, 4) homogeneous nucleation, 5) aggregation and growth of rod-like crystals and 6) DHRS formation. The DSSC device with a scattering layer made of DHRS (size similar to 300 nm) performed comparably to that with a scattering layer made of a commercially available TiO2 paste, making this nano-material a cost-effective alternative for future DSSC commercialization.
A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic SoC for Real-Time Epileptic Seizure Control
(2013-01-01)
Chen, Wei-Ming
;
Chiueh, Herming
;
Chen, Tsan-Jieh
;
Ho, Chia-Lun
;
Jeng, Chi
Process-Variation-Aware Iddq Diagnosis for Nano-Scale CMOS Designs - The First Step
(2013-01-01)
Chang, Chia-Ling (Lynn)
;
Wen, Charles H. -P
;
Bhadra, Jayanta
;
電機工程學系
;
Department of Electrical and Computer Engineering
Along with the shrinking CMOS process and rapid design scaling, both Iddq values and their variation of chips increase. As a result, the defect leakages become less significant when compared to the full-chip currents, making them more in-distinguishable for traditional Iddq diagnosis. Therefore, in this paper, a new approach called s-Iddq diagnosis is proposed for reinterpreting original data and diagnosing failing chips, intelligently. The overall flow consists of two key components, (1) s-Iddq transformation and (2) defect-syndrome matching: s-Iddq transformation first manifests defect leakages by excluding both the process-variation and design-scaling impacts. Later, defect-syndrome matching applies data mining with a pre-built library to identify types and locations of defects on the fly. Experimental results show that an average of 93.68% accuracy with a resolution of 1.75 defect suspects can be achieved on ISCAS'89 and IWLS'05 benchmark circuits using a 45nm technology, demonstrating the effectiveness of s-Iddq diagnosis.