Browsing by Issue Date, starting with "2013-02-16"

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具有環狀排列微生物載體之廢水處理方法與裝置
(2013-02-16)
黎德明
;
江明桂
;
陳金得
;
宋耿全
;
林志高
一種廢水處理方法與裝置，是於一反應槽中設置多數環狀排列之載體供微生物附著生長，反應槽中可分成一上反應區、一通道區以及一下反應區，通道區是被這些載體所圍繞，而且連通上、下反應區，微生物包含有自營性脫硝菌，而可產生Anammox反應將廢水中之NH4 + 以及NO2 - 轉換成氮氣，從而達到去除水中總氮之目的；由於載體能夠避免過多微生物隨著放流水排出反應槽，而將微生物儘可能地保留於反應槽內部，故此一廢水處理方法與裝置具較佳之處理效率。
多濾紙ＰＭ１０－ＰＭ２．５採樣器
(2013-02-16)
蔡春進
;
劉俊男
一種多濾紙PM 10-PM 2.5採樣器，可同時進行四組PM 10微粒樣本以及四組PM 2.5微粒樣本的採集，採樣器是使用一PM 10慣性衝擊器作為入口，採樣氣流通過PM 10慣性衝擊器後是被一分歧管分成兩等分，一部分之氣流被導入四組PM 10濾紙匣之中，而一部分之氣流則是在通過一PM 2.5慣性衝擊器之後，再被導入四組PM 2.5濾紙匣；為確保氣流均均地通過這些濾紙匣，每一組濾紙匣後端都設置一流孔板，以便提高每一採樣通道之壓損，從而使每一採樣通道之流量接近相同。
延遲元件及數位控制振盪器
(2013-02-16)
李鎮宜
;
余建螢
;
游佳融
一種延遲元件包含第一反相電晶體對、第二反相電晶體對以及複數個延遲單元。第一反相電晶體對用以接收輸入信號。第二反相電晶體對交錯耦接第一反相電晶體對，並由第一反相電晶體對交錯控制。延遲單元分別疊接於第一反相電晶體對之間以及第二反相電晶體對之間，用以提供連續之複數個信號傳遞延遲，其中輸入信號藉由第一反相電晶體對、第二反相電晶體對與延遲單元依序操作而延遲預設時間，以產生相對應預設時間之輸出信號。一種數位控制振盪器亦於此揭露。
腹式呼吸特徵萃取方法及使用此方法的腹式呼吸特徵萃取系統
(2013-02-16)
蕭子健
;
徐如欣
本發明揭露一種無需使用一腹式呼吸標準模型，且一受測者亦無需接受一學習程序，便可萃取出此受測者之腹式呼吸特徵的腹式呼吸特徵萃取方法。藉由運算出對應至其所讀取之腹式呼吸訊號的複數個內在模式函數的方式，本發明之腹式呼吸特徵萃取方法接續運算出各內在模式函數的一尤拉角函數及一瞬時頻率函數。隨後，這些瞬時頻率函數便依序與一預先設定之零點臨界值範圍互相比較，且依據比較所得之結果，本發明之腹式呼吸特徵萃取方法萃取出其中一個瞬時頻率函數作為一腹式呼吸特徵函數。如此，此受測者之腹式呼吸特徵被可被萃取出來。
移動預測方法
(2013-02-16)
林一平
;
皇甫建君
本發明係揭露一種移動預測方法，其係利用在複數基地台所涵蓋之複數相鄰之通訊細胞間移動與通訊之至少一通訊電話，於一預測時段內，對使用通訊電話之人口移動進行預測。首先，擷取在一天中，通訊電話於每一通訊細胞產生之一話務量，與通訊電話在通訊細胞交遞移動所產生之一交遞資訊。接著，計算話務量及交遞資訊，以得到一天內在不同之時段中，人口在通訊細胞間移動之移動機率，及人口在每一通訊細胞涵蓋之區域之一平均停駐時間。最後，依據求得之資料，預測在預測時段之時間終點時，人口出現在每一區域之一出現機率，進而達到人口移動預測。
電校式輻射計
(2013-02-16)
侯冠州
;
歐陽盟
;
邱俊誠
一種電校式熱輻射計，包含具有凹槽的基底、藉自基底延伸的支臂使片狀懸浮體對應位於凹槽上方的懸浮單元，及第一、二熱量測單元，其中，第一、二熱量測單元分別具有由熱敏材料且彼此相間隔地形成在懸浮體中的第一、二熱膜層，和二分別自第一、二熱膜層延伸並供電訊號輸入及輸出的第一、二電訊號臂，本發明藉自第一電訊號臂輸入已知電訊號令第一熱膜層相對第二熱膜層作為背景熱環境，即令第二熱膜層感受熱源溫度變化，並自第二電訊號臂傳輸的電訊號得知熱源溫度變化，藉此降低環境溫度造成的感測誤差，量得更精確的熱源絕對溫度變化。
時間至數位轉換器及數位控制時脈產生器及全數位時脈產生器
(2013-02-16)
許騰尹
;
廖原德
;
蘇楷書
一種全數位時脈產生器包括一數位控制時脈產生器和一處理單元。該數位控制時脈產生器響應一致能訊號和一數位訊號而產生一時脈訊號。該處理單元具有一頻率乘數和一參考訊號，該參考訊號具有一週期，該處理單元數位化該週期來產生一量化訊號，根據該量化訊號和該頻率乘數而產生該數位訊號，且根據該參考訊號、該時脈訊號和該頻率乘數而產生該致能訊號。
用於減緩介金屬化合物成長之方法
(2013-02-16)
陳智
;
杜經寧
;
蕭翔耀
本發明係有關於一種用於減緩介金屬化合物成長之方法，步驟包含：(i)製備一基板元件，包括在一基板上電鍍至少一金屬墊層，接著在該金屬墊層上電鍍至少一很薄的一薄銲料，進行適當的熱處理製程；(ii)在該基板元件上再鍍上適當厚度的銲料；其中，該薄銲料經過適當的熱處理後，會與金屬墊之金屬反應形成一薄的介金屬化合物，因此可以在之後的迴銲製程抑制介金屬化合物的生成速率之效果，藉以減緩微小接點銲料與金屬墊上的金屬反應變成介金屬化合物。一旦介金屬化合物成長速率能被減緩，錫晶鬚(Sn whisker)的成長也可以被抑制。
Hole injection-reduced hot carrier degradation in n-channel metal-oxide-semiconductor field-effect-transistors with high-k gate dielectric
(2013-02-18)
Tsai, Jyun-Yu
;
Chang, Ting-Chang
;
Lo, Wen-Hung
;
Chen, Ching-En
;
Ho, Szu-Han
This work finds a significant difference in degradation under hot carrier stress (HCS) due to additional hole injection in n-channel metal-oxide-semiconductor field-effect-transistors with high-k gate dielectric. A comparison performed on degradation of input/output (I/O) and standard performance (SP) devices showed that performance degradation of the I/O device is worse than the SP device under HCS. For the SP device, both channel-electrons and hot holes can inject into gate dielectric, in which hole acts to diminish the stress field. However, I/O device shows only electron injection. The proposed model is confirmed by gate induced drain leakage current and simulation tool. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4791676]
Walking assistive system
(2013-02-19)
Song Kai-Tai
;
Jiang Sin-Yi
;
Huang Ko-Tung
The present invention discloses a walking assistive system comprising a motion module, a current detecting module and a central control module. Each motion module includes omni-directional wheels, motors, shaft encoders and servo controllers. The omni-directional wheels are connected to and driven by the motors. The motors are connected to the shaft encoders, and the rotation speed values are generated corresponds to the rotation speed of the motors by the shaft coder. The servo controllers connected to the shaft encoders and the motors receive the rotation speed values and control the motors. The current detecting modules connected to the motors detect the current of the motors and generate current values correspondingly. The central control module connected to the motion control module and the current detecting module controls the platform compliant motion control modules according to the rotation speed values and the current values.
ESD protection circuitry with multi-finger SCRS
(2013-02-19)
Ker Ming-Dou
;
Lin Chun-Yu
;
Wang Chang-Tzu
Self-triggered Multi-finger SCRs used in ESD protection circuitry capable of turning on all SCR fingers of the multi-finger SCRs include a first source, a second source, N SCR units, (N−1) diodes, and N resistors. Each of the N SCR units includes a first node, a second node coupled to the second source, and a trigger node. An nth diode of the (N−1) diodes is coupled between a first node of an nth SCR unit and a trigger node of an (n+1)th SCR unit. An nth resistor is coupled between the first node of the nth SCR unit and the first source, wherein n and N are integers. The (N−1) diodes can be replaced by directly coupled the first node of the nth SCR unit to the trigger node of the (n+1)th SCR unit when a trigger pulse is applied at the trigger node of a first SCR unit.
Fouling mitigation of a dead-end microfiltration by mixing-enhanced preoxidation for Fe and Mn removal from groundwater
(2013-02-20)
Lin, Jr-Lin
;
Huang, Chihpin
;
Ruhsing, Pan Jill
;
Wang, Yau-Shian
;
環境工程研究所
A combination of oxidation and microfiltration (oxidation-MF) is commonly used to remove Fe and Mn from groundwater. The characteristics of Fe and Mn oxides formed by oxidation can be significantly affected by the mixing intensity during oxidation, which subsequently influences the performance of membrane filtration. To optimize oxidation-MF, the critical role of mixing intensity on Fe and Mn oxide formation was investigated. Sufficient oxidant (NaOCl) was added to a prepared ferrous solution with or without Mn ions to oxidize the ions at different mixing intensities, followed by a dead-end MF for 30 min at a constant transmembrane pressure of 1 kg/cm(2). A custom-made module surrounded by a tube membrane was used in microfiltration. The resistance of membrane filtration was calculated by a resistance-in-series model. Cake resistance (R-c) dominated the fouling of the membrane, which depended on the composition of oxides. Oxides formed at high mixing intensity were smaller and more compact, which resulted in reduced R-c, and increased permeate flux. The presence of oxidized Mn aggravated membrane fouling. Permeate flux declined rapidly as a result of the cake formed by Fe-Mn oxides with increased hydrophobicity. The irreversible fouling of the dead-end MF was insensitive to mixing intensity during prechlorination, while the irreversible fouling induced by Fe-Mn oxides was more severe than that by Fe oxides as membrane filtration cycle progressed. The results show that membrane flux of a dead-MF can be effectively improved by prechlorination with enhanced mixing due to the formation of a permeable cake layer with low cake compressibility in the membrane filtration. (c) 2012 Elsevier B.V. All rights reserved.
Effect of nanoholes on the vortex core fermion spectrum and heat transport in p-wave superconductors
(2013-02-20)
Rosenstein, B.
;
Shapiro, I.
;
Shapiro, B. Ya
;
電子物理學系
;
Department of Electrophysics
The spectrum of core excitations of the Abrikosov vortex pinned by a nanohole of the size of the coherence length is considered. While the neutral zero energy Majorana core state remains intact due to its topological origin, the energy of charged excitations is significantly enhanced compared to that in the unpinned vortex. As a consequence of the pinning the minigap separating the Majorana state from the charged levels increases from Delta(2)/E-F (E-F is the Fermi energy and Delta is the bulk p-wave superconducting gap) to a significant fraction of Delta. Suppression of the thermodynamic and kinetic effects of the charged excitations allows us to isolate the Majorana state so it can be used for quantum computation. It is proposed that thermal conductivity along the vortex cores is a sensitive method to demonstrate the minigap. Using the Butticker-Landauer-Kopnin formula, we calculate the thermal conductance beyond the linear response as a function of the hole radius.
Computational Analysis of KRAS Mutations: Implications for Different Effects on the KRAS p.G12D and p.G13D Mutations
(2013-02-20)
Chen, Chih-Chieh
;
Er, Tze-Kiong
;
Liu, Yen-Yi
;
Hwang, Jenn-Kang
;
Jesus Barrio, Maria
Background: The issue of whether patients diagnosed with metastatic colorectal cancer who harbor KRAS codon 13 mutations could benefit from the addition of anti-epidermal growth factor receptor therapy remains under debate. The aim of the current study was to perform computational analysis to investigate the structural implications of the underlying mutations caused by c.38G>A (p.G13D) on protein conformation. Methods: Molecular dynamics (MD) simulations were performed to understand the plausible structural and dynamical implications caused by c.35G>A (p.G12D) and c.38G>A (p.G13D). The potential of mean force (PMF) simulations were carried out to determine the free energy profiles of the binding processes of GTP interacting with wild-type (WT) KRAS and its mutants (MT). Results: Using MD simulations, we observed that the root mean square deviation (RMSD) increased as a function of time for the MT c.35G>A (p.G12D) and MT c.38G>A (p.G13D) when compared with the WT. We also observed that the GTP-binding pocket in the c.35G>A (p.G12D) mutant is more open than that of the WT and the c.38G>A (p.G13D) proteins. Intriguingly, the analysis of atomic fluctuations and free energy profiles revealed that the mutation of c.35G>A (p.G12D) may induce additional fluctuations in the sensitive sites (P-loop, switch I and II regions). Such fluctuations may promote instability in these protein regions and hamper GTP binding. Conclusions: Taken together with the results obtained from MD and PMF simulations, the present findings implicate fluctuations at the sensitive sites (P-loop, switch I and II regions). Our findings revealed that KRAS mutations in codon 13 have similar behavior as KRAS WT. To gain a better insight into why patients with metastatic colorectal cancer (mCRC) and the KRAS c.38G>A (p.G13D) mutation appear to benefit from anti-EGFR therapy, the role of the KRAS c.38G>A (p.G13D) mutation in mCRC needs to be further investigated.
Parallel Screening of Wild-Type and Drug-Resistant Targets for Anti-Resistance Neuraminidase Inhibitors
(2013-02-20)
Hsu, Kai-Cheng
;
Hung, Hui-Chen
;
Horng, Jim-Tong
;
Fang, Ming-Yu
;
Chang, Chun-Yu
Infection with influenza virus is a major public health problem, causing serious illness and death each year. Emergence of drug-resistant influenza virus strains limits the effectiveness of drug treatment. Importantly, a dual H275Y/I223R mutation detected in the pandemic influenza A 2009 virus strain results in multidrug resistance to current neuraminidase (NA) drugs. Therefore, discovery of new agents for treating multiple drug-resistant (MDR) influenza virus infections is important. Here, we propose a parallel screening strategy that simultaneously screens wild-type (WT) and MDR NAs, and identifies inhibitors matching the subsite characteristics of both NA-binding sites. These may maintain their potency when drug-resistant mutations arise. Initially, we analyzed the subsite of the dual H275Y/I223R NA mutant. Analysis of the site-moiety maps of NA protein structures show that the mutant subsite has a relatively small volume and is highly polar compared with the WT subsite. Moreover, the mutant subsite has a high preference for forming hydrogen-bonding interactions with polar moieties. These changes may drive multidrug resistance. Using this strategy, we identified a new inhibitor, Remazol Brilliant Blue R (RB19, an anthraquinone dye), which inhibited WT NA and MDR NA with IC50 values of 3.4 and 4.5 mu M, respectively. RB19 comprises a rigid core scaffold and a flexible chain with a large polar moiety. The former interacts with highly conserved residues, decreasing the probability of resistance. The latter forms van der Waals contacts with the WT subsite and yields hydrogen bonds with the mutant subsite by switching the orientation of its flexible side chain. Both scaffolds of RB19 are good starting points for lead optimization. The results reveal a parallel screening strategy for identifying resistance mechanisms and discovering anti-resistance neuraminidase inhibitors. We believe that this strategy may be applied to other diseases with high mutation rates, such as cancer and human immunodeficiency virus type 1.
Microstructure and magnetic properties of oxidized titanium nitride thin films in situ grown by pulsed laser deposition
(2013-02-20)
Chen, S. C.
;
Sung, K. Y.
;
Tzeng, W. Y.
;
Wu, K. H.
;
Juang, J. Y.
Different oxidation states of titanium nitride thin films, including pure TiN(h 0 0), TiN1-xOx(h 0 0), Ti2O3(0 0 l) and pure anatase TiO2(0 0 l), were prepared by pulsed laser deposition with various oxygen pressures (P-O2) using a TiN target. Elaborative evolutions of the crystal and electronic structures of the obtained films were examined systematically by x-ray diffraction and x-ray absorption spectroscopy. We found that the Ti2O3(0 0 l) film, which was prepared at oxygen pressures P-O2 = 10(-4) Torr, exhibited the maximum room temperature ferromagnetism (RTFM) behaviour. The bound magnetic polaron model is used to clarify the origin of RTFM in these films.
Coherent pi-electron dynamics of (P)-2,2 '-biphenol induced by ultrashort linearly polarized UV pulses: Angular momentum and ring current
(2013-02-21)
Mineo, H.
;
Lin, S. H.
;
Fujimura, Y.
;
應用化學系分子科學碩博班
;
Institute of Molecular science
The results of a theoretical investigation of coherent pi-electron dynamics for nonplanar (P)-2,2'-biphenol induced by ultrashort linearly polarized UV pulses are presented. Expressions for the time-dependent coherent angular momentum and ring current are derived by using the density matrix method. The time dependence of these coherences is determined by the off-diagonal density matrix element, which can be obtained by solving the coupled equations of motion of the electronic-state density matrix. Dephasing effects on coherent angular momentum and ring current are taken into account within the Markov approximation. The magnitudes of the electronic angular momentum and current are expressed as the sum of expectation values of the corresponding operators in the two phenol rings (L and R rings). Here, L (R) denotes the phenol ring in the left (right)-hand side of (P)-2,2'-biphenol. We define the bond current between the nearest neighbor carbon atoms C-i and C-j as an electric current through a half plane perpendicular to the C-i-C-j bond. The bond current can be expressed in terms of the inter-atomic bond current. The inter-atomic bond current (bond current) depends on the position of the half plane on the bond and has the maximum value at the center. The coherent ring current in each ring is defined by averaging over the bond currents. Since (P)-2,2'-biphenol is nonplanar, the resultant angular momentum is not one-dimensional. Simulations of the time-dependent coherent angular momentum and ring current of (P)-2,2'-biphenol excited by ultrashort linearly polarized UV pulses are carried out using the molecular parameters obtained by the time-dependent density functional theory (TD-DFT) method. Oscillatory behaviors in the time-dependent angular momentum (ring current), which can be called angular momentum (ring current) quantum beats, are classified by the symmetry of the coherent state, symmetric or antisymmetric. The bond current of the bridge bond linking the L and R rings is zero for the symmetric coherent state, while it is nonzero for the antisymmetric coherent state. The magnitudes of ring current and ring current-induced magnetic field are also evaluated, and their possibility as a control parameter in ultrafast switching devices is discussed. The present results give a detailed description of the theoretical treatment reported in our previous paper [H. Mineo, M. Yamaki, Y. Teranish, M. Hayashi, S. H. Lin, and Y. Fujimura, J. Am. Chem. Soc. 134, 14279 (2012)]. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4790595]
可注射性智慧凝膠及其製備方法
(2013-02-21)
劉典謨
;
蕭孟軒
;
林立傑
一種可注射性智慧凝膠及其製備方法，係對於改質後之幾丁聚醣，加入鹼性結構安定劑及稀釋溶液，而將幾丁聚醣溶液調整為偏中性，以接近人體之pH值，並可在低溫下形成可流動狀態的幾丁聚醣溶膠，當回到人體溫度則形成不可流動之幾丁聚醣凝膠，或者，利用於幾丁聚醣溶液中加入高分子電解液後再添加鈣離子或調成酸性溶液的方式，亦可將可流動狀態的幾丁聚醣溶膠轉為不可流動的幾丁聚醣凝膠，藉此製備而成的可注射性智慧凝膠不但具有可注射性，同時，可作為已載有藥物分子的磁敏性奈米膠囊之藥物載體凝膠，經由外加的磁場、電場及超音波等非接觸力的方式，控制其膠囊的破裂而釋放藥物至可注射性智慧凝膠中，再進行長時效及可階段性的藥物釋放，在生醫工程方面極具利用價值。
高分子基板之高頻覆晶封裝製程及其結構
(2013-02-21)
張翼
;
許立翰
;
胡志偉
;
吳偉誠
;
王景德
本發明係提供一種高分子基板之高頻覆晶封裝製程及其結構，其係利用一階層之高頻覆晶封裝製程所封裝之結構，該結構可有效解決習用經由二階層之高頻覆晶封裝製程所製造之結構，其不僅在高頻特性上會帶來一額外之入射損耗與反射損耗，同時在應用上容易產生一可靠度問題、以及在該習用結構中之一陶瓷基板的製程良率上，仍存在有不佳及成本偏高等缺點。
Infrared identification of the sigma-complex of Cl-C6H6 in the reaction of chlorine atom and benzene in solid para-hydrogen
(2013-02-21)
Bahou, Mohammed
;
Witek, Henryk
;
Lee, Yuan-Pern
;
應用化學系
;
應用化學系分子科學碩博班
The reaction of a chlorine atom with benzene (C6H6) is important in organic chemistry, especially in site-selective chlorination reactions, but its product has been a subject of debate for five decades. Previous experimental and theoretical studies provide no concrete conclusion on whether the product is a pi- or sigma-form of the Cl-C6H6 complex. We took advantage of the diminished cage effect of para-hydrogen (p-H-2) to produce Cl in situ to react with C6H6 (or C6D6) upon photolysis of a Cl-2/C6H6 (or C6D6)/p-H-2 matrix at 3.2 K. The infrared spectrum, showing intense lines at 1430.5, 833.6, 719.8, 617.0, and 577.4 cm(-1), and several weaker ones for Cl-C6H6, and the deuterium shifts of observed new lines unambiguously indicate that the product is a 6-chlorocyclohexadienyl radical, i.e., the sigma-complex of Cl-C6H6. Observation of the s-complex rather than the pi-complex indicates that the s-complex is more stable in solid p-H-2 at 3.2 K. The spectral information is crucial for further investigations of the Cl + C6H6 reaction either in the gaseous or solution phase. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4790860]