Browsing by Issue Date, starting with "2014-05-14"

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Multianalyte biosensor based on pH-sensitive ZnO electrolyte-insulator-semiconductor structures
(2014-05-14)
Kao, Chyuan Haur
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Chen, Hsiang
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Lee, Ming Ling
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Liu, Che Chun
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Ueng, Herng-Yih
Multianalyte electrolyte-insulator-semiconductor (EIS) sensors with a ZnO sensing membrane annealed on silicon substrate for use in pH sensing were fabricated. Material analyses were conducted using X-ray diffraction and atomic force microscopy to identify optimal treatment conditions. Sensing performance for various ions of Na+, K+, urea, and glucose was also tested. Results indicate that an EIS sensor with a ZnO membrane annealed at 600 degrees C exhibited good performance with high sensitivity and a low drift rate compared with all other reported ZnO-based pH sensors. Furthermore, based on well-established pH sensing properties, pH-ion-sensitive field-effect transistor sensors have also been developed for use in detecting urea and glucose ions. ZnO-based EIS sensors show promise for future industrial biosensing applications. (C) 2014 AIP Publishing LLC.
Propensity Scores for Prediction and Characterization of Bioluminescent Proteins from Sequences
(2014-05-14)
Huang, Hui-Ling
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生物科技學系
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生物資訊及系統生物研究所
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Department of Biological Science and Technology
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Institude of Bioinformatics and Systems Biology
Bioluminescent proteins (BLPs) are a class of proteins with various mechanisms of light emission such as bioluminescence and fluorescence from luminous organisms. While valuable for commercial and medical applications, identification of BLPs, including luciferases and fluorescent proteins (FPs), is rather challenging, owing to their high variety of protein sequences. Moreover, characterization of BLPs facilitates mutagenesis analysis to enhance bioluminescence and fluorescence. Therefore, this study proposes a novel methodological approach to estimating the propensity scores of 400 dipeptides and 20 amino acids in order to design two prediction methods and characterize BLPs based on a scoring card method (SCM). The SCMBLP method for predicting BLPs achieves an accuracy of 90.83% for 10-fold cross-validation higher than existing support vector machine based methods and a test accuracy of 82.85%. A dataset consisting of 269 luciferases and 216 FPs is also established to design the SCMLFP prediction method, which achieves training and test accuracies of 97.10% and 96.28%, respectively. Additionally, four informative physicochemical properties of 20 amino acids are identified using the estimated propensity scores to characterize BLPs as follows: 1) high transfer free energy from inside to the protein surface, 2) high occurrence frequency of residues in the transmembrane regions of the protein, 3) large hydrophobicity scale from the native protein structure, and 4) high correlation coefficient (R = 0.921) between the amino acid compositions of BLPs and integral membrane proteins. Further analyzing BLPs reveals that luciferases have a larger value of R (0.937) than FPs (0.635), suggesting that luciferases tend to locate near the cell membrane location rather than FPs for convenient receipt of extracellular ions. Importantly, the propensity scores of dipeptides and amino acids and the identified properties facilitate efforts to predict, characterize, and apply BLPs, including luciferases, photoproteins, and FPs. The web server is available at http://iclab.life.nctu.edu.tw/SCMBLP/index.html.
Evaluation of subcortical grey matter abnormalities in patients with MRI-negative cortical epilepsy determined through structural and tensor magnetic resonance imaging
(2014-05-14)
Peng, Syu-Jyun
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Harnod, Tomor
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Tsai, Jang-Zern
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Ker, Ming-Dou
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Chiou, Jun-Chern
Background: Although many studies have found abnormalities in subcortical grey matter (GM) in patients with temporal lobe epilepsy or generalised epilepsies, few studies have examined subcortical GM in focal neocortical seizures. Using structural and tensor magnetic resonance imaging (MRI), we evaluated subcortical GM from patients with extratemporal lobe epilepsy without visible lesion on MRI. Our aims were to determine whether there are structural abnormalities in these patients and to correlate the extent of any observed structural changes with clinical characteristics of disease in these patients. Methods: Twenty-four people with epilepsy and 29 age-matched normal subjects were imaged with high-resolution structural and diffusion tensor MR scans. The patients were characterised clinically by normal brain MRI scans and seizures that originated in the neocortex and evolved to secondarily generalised convulsions. We first used whole brain voxel-based morphometry (VBM) to detect density changes in subcortical GM. Volumetric data, values of mean diffusivity (MD) and fractional anisotropy (FA) for seven subcortical GM structures (hippocampus, caudate nucleus, putamen, globus pallidus, nucleus accumbens, thalamus and amygdala) were obtained using a model-based segmentation and registration tool. Differences in the volumes and diffusion parameters between patients and controls and correlations with the early onset and progression of epilepsy were estimated. Results: Reduced volumes and altered diffusion parameters of subcortical GM were universally observed in patients in the subcortical regions studied. In the patient-control group comparison of VBM, the right putamen, bilateral nucleus accumbens and right caudate nucleus of epileptic patients exhibited a significantly decreased density Segregated volumetry and diffusion assessment of subcortical GM showed apparent atrophy of the left caudate nucleus, left amygdala and right putamen; reduced FA values for the bilateral nucleus accumbens; and elevated MD values for the left thalamus, right hippocampus and right globus pallidus A decreased volume of the nucleus accumbens consistently related to an early onset of disease. The duration of disease contributed to the shrinkage of the left thalamus. Conclusions: Patients with neocortical seizures and secondary generalisation had smaller volumes and microstructural anomalies in subcortical GM regions. Subcortical GM atrophy is relevant to the early onset and progression of epilepsy.
Enhanced Performance of Organic Thin Film Solar Cells Using Electrodes with Nanoimprinted Light-Diffraction and Light-Diffusion Structures
(2014-05-14)
Chen, Jheng-Yuan
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Yu, Ming-Hung
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Chang, Chih-Yu
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Chao, Yi-Hsiang
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Sun, Kien Wen
An ITO substrate with periodic surface nanostructures was used to induce strong diffusion and diffraction of incident light. The nanostructures were fabricated using nanoimprint lithography on photoresist followed by coating of the ITO layer and organic materials with uniform morphology. The nanostructures embedded into the ITO layer were found to increase absorption in poly(3-hexylthiophene) : [6,6]-phenyl-C61-butyric acid methyl ester solar devices. The short-circuit current of the nanostructured organic solar cells improved from 7.07 to 10.76 mA/cm(2). This improvement was due to the increased effective optical path of absorbed light resulting from the trapping and scattering by the nanostructures.
RESISTIVE RANDOM ACCESS MEMORY DEVICE AND OPERATING METHOD THEREOF
(2014-05-15)
LIU Po-Tsun
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HSU Ching-Hui
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FAN Yang-Shun
A resistive random access memory (RRAM) device and operating method are disclosed herein. The RRAM device includes at least one RRAM cell and a control circuit. The RRAM cell includes a bottom electrode, an amorphous Indium-Gallium-Zinc-Oxide (a-IGZO) layer, a Ti layer and a top electrode. The a-IGZO layer is disposed on the bottom layer. The Ti layer is disposed on the a-IGZO layer. The top electrode is disposed on the Ti layer. The control circuit is configured to provide at least one electrical signal to the RRAM cell, so as to change the resistance value of the RRAM cell.
Stress singularities in an anisotropic body of revolution
(2014-05-15)
Huang, C. S.
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Hu, C. N.
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Lee, C. C.
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Chang, M. J.
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土木工程學系
To fill the gap in the literature on the application of three-dimensional elasticity theory to geometrically induced stress singularities, this work develops asymptotic solutions for Williams-type stress singularities in bodies of revolution that are made of rectilinearly anisotropic materials. The Cartesian coordinate system used to describe the material properties differs from the coordinate system used to describe the geometry of a body of revolution, so the problems under consideration are very complicated. The eigenfunction expansion approach is combined with a power series solution technique to find the asymptotic solutions by directly solving the three-dimensional equilibrium equations in terms of the displacement components. The correctness of the proposed solution is verified by convergence studies and by comparisons with results obtained using closed-form characteristic equations for an isotropic body of revolution and using the commercial finite element program ABAQUS for orthotropic bodies of revolution. Thereafter, the solution is employed to comprehensively examine the singularities of bodies of revolution with different geometries, made of a single material or bi-materials, under different boundary conditions. (C) 2014 Elsevier Ltd. All rights reserved.
可攜式二維血氧顯影裝置
(2014-05-16)
方偉騏
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陳殿河
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康適
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吳世揚
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鄭敬儒
本發明提供一種可攜式二維血氧顯影裝置，可先透過前端偵測器之複數個光源發送檢測光線至一待測物體，由複數個感測器感測該檢測光線經該待測物體反射後的光源強度，接著，由分析處理器接收該前端偵測器所偵測到之該光源強度，並分析該光源強度以依據一血氧濃度分布演算法產生該待測物體之各區域組織的血氧濃度分布資訊，之後，令影像重建器依據該分析處理器所產生之血氧濃度分布資訊進行影像重建，產生以色階差異表示該待測物體之各區域組織之血氧飽和濃度的顯影資訊。透過本發明之可攜式二維血氧顯影裝置，可提供區域性偵測範圍，將有助於提升偵測的準確性。
Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds
(2014-05-16)
Hsu, Tzu-Chia
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Liu, Kuang-Kai
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Chang, Huan-Cheng
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Hwang, Eric
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Chao, Jui-I
Nanodiamond is a promising carbon nanomaterial developed for biomedical applications. Here, we show fluorescent nanodiamond (FND) with the biocompatible properties that can be used for the labeling and tracking of neuronal differentiation and neuron cells derived from embryonal carcinoma stem (ECS) cells. The fluorescence intensities of FNDs were increased by treatment with FNDs in both the mouse P19 and human NT2/D1 ECS cells. FNDs were taken into ECS cells; however, FNDs did not alter the cellular morphology and growth ability. Moreover, FNDs did not change the protein expression of stem cell marker SSEA-1 of ECS cells. The neuronal differentiation of ECS cells could be induced by retinoic acid (RA). Interestingly, FNDs did not affect on the morphological alteration, cytotoxicity and apoptosis during the neuronal differentiation. Besides, FNDs did not alter the cell viability and the expression of neuron-specific marker beta-III-tubulin in these differentiated neuron cells. The existence of FNDs in the neuron cells can be identified by confocal microscopy and flow cytometry. Together, FND is a biocompatible and readily detectable nanomaterial for the labeling and tracking of neuronal differentiation process and neuron cells from stem cells.
開關切換驅動方法
(2014-05-16)
胡竹生
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饒憲堂
本發明揭露一種開關切換驅動方法，其係適用於一驅動系統，透過開關策略解調變，將欲設定之任意驅動波形轉為開關訊號陣列，並傳送至開關電路，透過開關電路高速的開關動作，藉此達成產生任意驅動波形之目標，並使用開關電路搭配開關策略，以產生任意波型，降低開關所造成損失，提高多通道，以及多組任意波型驅動訊號的調變能力。
利用遮光模組達到影像自動對焦之裝置及其方法
(2014-05-16)
石勝文
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莊耀棟
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洪譽倫
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黃國政
一種利用遮光模組達到影像自動對焦之裝置及其方法,其係包含有一光源、非對稱遮光模組、光電轉換元件以及用以移動光電轉換元件至不同感光位置之驅動馬達。此種影像自動對焦之裝置只需要在取像設備的鏡頭上加裝遮光模組,由於點光源會在人類角膜後方約與虹膜相同對焦平面上形成虛像,所以當虹膜紋理失焦時,點光源的虛像也會離焦。本發明係利用一個離焦的點光源的虛像將非對稱遮光模組的外形投射到影像平面形成與遮光模組相似形狀之非對稱亮點,其亮點的大小和方向即可以用來推算聚焦虹膜紋理需要移動的位移量與所需的調整方向。
電阻式記憶體裝置及其操作方法
(2014-05-16)
劉柏村
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許沁卉
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范揚順
電阻式記憶體裝置及其操作方法在此揭露。電阻式記憶體裝置包括至少一個電阻式記憶體元件以及控制電路。電阻式記憶體元件包括底電極、非晶態氧化銦鎵鋅(amorphous Indium-Gallium-Zinc-Oxide,a-IGZO)層、鈦層以及頂電極。非晶態氧化銦鎵鋅層配置於底電極上。鈦層配置於非晶態氧化銦鎵鋅層。頂電極配置於鈦層上。控制電路用以提供電訊號給電阻式記憶體元件,以改變電阻式記憶體元件的電阻値。
白光發光二極體封裝結構的製造方法
(2014-05-16)
王興宗
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郭浩中
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陳信助
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陳國儒
一種白光發光二極體封裝結構的製造方法,包括:提供基板;提供發光二極體晶片,且將發光二極體晶片置放在基板上且與基板以導線電性連接,使得在基板及在發光二極體晶片之上形成容置空間;執行封裝製程,係於容置空間內填入封裝材料以包覆發光二極體晶片、導線及基板表面以形成封裝結構;形成螢光粉層在封裝結構之表面上;以及形成含氧化物膠層在螢光粉層上。一種白光發光二極體封裝結構,包括:發光二極體封裝結構;螢光粉層,設置在發光二極體封裝結構之表面上;以及含氧化物膠層,設置在該螢光粉層之上。
有機茶　友善環境的濃縮
(2014-05-18)
林凱元
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Department of Communication and Technology
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傳播與科技學系
城市與鄉村的關係，有機與友善環境的聯結，這是現代人飲食的重要議題。
脊髓損傷知多少
(2014-05-18)
陳佩瑄
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Department of Communication and Technology
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傳播與科技學系
任何外力造成脊髓的不穩定甚或脫位，因而引起脊髓組織的損傷及神經功能的缺損均稱之為脊髓損傷。
揭開神秘面紗　矮靈祭
(2014-05-18)
楊哲維
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Department of Communication and Technology
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傳播與科技學系
矮靈祭是賽夏族的傳統慶典，過去因為不對外開放，而帶有神秘色彩。
貪婪漁業　招致自我毀滅
(2014-05-18)
黃筱雯
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Department of Communication and Technology
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傳播與科技學系
《獵殺海洋：一部自我毀滅的人類文明史》一書對比過往與現今海洋生態情景，提倡設置海洋保留區，恢復生機。
梅竹男籃　制度爭議仍存
(2014-05-18)
柯惠文
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Department of Communication and Technology
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傳播與科技學系
梅竹賽近幾年爭議不斷，屢屢停賽，但在兩校校長的推動之下，今年選在交大體育館進行了男籃友誼賽。
走過風風雨雨　中職不停歇
(2014-05-18)
林庭宇
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Department of Communication and Technology
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傳播與科技學系
綜觀中華職棒二十五年的歷史，其中經歷過不少關卡，有過失望和期待，而這些歷練卻成就今日的中華職棒。
陶瓷定位大不同
(2014-05-18)
彭士捷
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Department of Communication and Technology
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傳播與科技學系
金融海嘯過後，面對全球化的競爭，鶯歌陶瓷的定位已經逐漸由日用品轉向藝術品發展。
總編輯的話
(2014-05-18)
林燕婷
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Department of Communication and Technology
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傳播與科技學系
本期喀報共有14篇稿件，記者深入採訪具議題性的新聞，讓報導更加精采，極具深度。