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On tests of treatment-covariate interactions: An illustration of appropriate power and sample size calculations
(2017-05-17)
Shieh, Gwowen
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管理科學系
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Department of Management Science
The appraisals of treatment-covariate interaction have theoretical and substantial implications in all scientific fields. Methodologically, the detection of interaction between categorical treatment levels and continuous covariate variables is analogous to the homogeneity of regression slopes test in the context of ANCOVA. A fundamental assumption of ANCOVA is that the regression slopes associating the response variable with the covariate variable are presumed constant across treatment groups. The validity of homogeneous regression slopes accordingly is the most essential concern in traditional ANCOVA and inevitably determines the practical usefulness of research findings. In view of the limited results in current literature, this article aims to present power and sample size procedures for tests of heterogeneity between two regression slopes with particular emphasis on the stochastic feature of covariate variables. Theoretical implications and numerical investigations are presented to explicate the utility and advantage for accommodating covariate properties. The exact approach has the distinct feature of accommodating the full distributional properties of normal covariates whereas the simplified approximate methods only utilize the partial information of covariate variances. According to the overall accuracy and robustness, the exact approach is recommended over the approximate methods as a reliable tool in practical applications. The suggested power and sample size calculations can be implemented with the supplemental SAS and R programs.
A systematic approach to designing statistically powerful heteroscedastic 2 x 2 factorial studies while minimizing financial costs
(2016-08-31)
Jan, Show-Li
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Shieh, Gwowen
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管理科學系
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Department of Management Science
Background: The 2 x 2 factorial design is widely used for assessing the existence of interaction and the extent of generalizability of two factors where each factor had only two levels. Accordingly, research problems associated with the main effects and interaction effects can be analyzed with the selected linear contrasts. Methods: To correct for the potential heterogeneity of variance structure, the Welch-Satterthwaite test is commonly used as an alternative to the t test for detecting the substantive significance of a linear combination of mean effects. This study concerns the optimal allocation of group sizes for the Welch-Satterthwaite test in order to minimize the total cost while maintaining adequate power. The existing method suggests that the optimal ratio of sample sizes is proportional to the ratio of the population standard deviations divided by the square root of the ratio of the unit sampling costs. Instead, a systematic approach using optimization technique and screening search is presented to find the optimal solution. Results: Numerical assessments revealed that the current allocation scheme generally does not give the optimal solution. Alternatively, the suggested approaches to power and sample size calculations give accurate and superior results under various treatment and cost configurations. Conclusions: The proposed approach improves upon the current method in both its methodological soundness and overall performance. Supplementary algorithms are also developed to aid the usefulness and implementation of the recommended technique in planning 2 x 2 factorial designs.
Determining Sample Sizes for Precise Contrast Analysis With Heterogeneous Variances
(2014-04-01)
Jan, Show-Li
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Shieh, Gwowen
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交大名義發表
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National Chiao Tung University
The analysis of variance (ANOVA) is one of the most frequently used statistical analyses in practical applications. Accordingly, the single and multiple comparison procedures are frequently applied to assess the differences among mean effects. However, the underlying assumption of homogeneous variances may not always be tenable. This study examines the sample size procedures for precise interval estimation of linear contrasts within the context of one-way heteroscedastic ANOVA models. The desired precision of both individual and simultaneous confidence intervals is evaluated with respect to the control of expected half width and to the tolerance probability of interval half width within a designated value. Supplementary computer programs are developed to aid the usefulness and implementation of the proposed techniques. The suggested sample size procedures improve upon the existing approaches and extend the methodology development in the statistical literature.
Sample size determinations for Welch's test in one-way heteroscedastic ANOVA
(2014-02-01)
Jan, Show-Li
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Shieh, Gwowen
;
交大名義發表
;
管理科學系
;
National Chiao Tung University
For one-way fixed effects ANOVA, it is well known that the conventional F test of the equality of means is not robust to unequal variances, and numerous methods have been proposed for dealing with heteroscedasticity. On the basis of extensive empirical evidence of Type I error control and power performance, Welch's procedure is frequently recommended as the major alternative to the ANOVA F test under variance heterogeneity. To enhance its practical usefulness, this paper considers an important aspect of Welch's method in determining the sample size necessary to achieve a given power. Simulation studies are conducted to compare two approximate power functions of Welch's test for their accuracy in sample size calculations over a wide variety of model configurations with heteroscedastic structures. The numerical investigations show that Levy's (1978a) approach is clearly more accurate than the formula of Luh and Guo (2011) for the range of model specifications considered here. Accordingly, computer programs are provided to implement the technique recommended by Levy for power calculation and sample size determination within the context of the one-way heteroscedastic ANOVA model.
Sample size requirements for interval estimation of the strength of association effect sizes in multiple regression analysis
(2013-08-01)
Shieh, Gwowen
;
交大名義發表
;
管理科學系
;
National Chiao Tung University
;
Department of Management Science
Background: Effect size reporting and interpreting practices have been extensively recommended in academic journals when analyzing primary outcomes of all empirical studies. Accordingly, the sample squared multiple correlation coefficient is the commonly reported strength of association index in practical applications of multiple linear regression. Method: This paper examines the sample size procedures proposed by Bonett and Wright for precise interval estimation of the squared multiple correlation coefficient. Results: The simulation results showed that their simple method for attaining the desired precision of expected width provides satisfactory results only when sample sizes are large. Moreover, the suggested sample size formula for achieving the designated assurance probability is inaccurate and problematic. Conclusions: According to these findings, their sample size procedures are not recommended.
Confidence intervals and sample size calculations for the weighted eta-squared effect sizes in one-way heteroscedastic ANOVA
(2013-03-01)
Shieh, Gwowen
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管理科學系
;
Department of Management Science
Effect size reporting and interpreting practices have been extensively recommended in academic journals when primary outcomes of all empirical studies have been analyzed. This article presents an alternative approach to constructing confidence intervals of the weighted eta-squared effect size within the context of one-way heteroscedastic ANOVA models. It is shown that the proposed interval procedure has advantages over an existing method in its theoretical justification, computational simplicity, and numerical performance. For design planning, the corresponding sample size procedures for precise interval estimation of the weighted eta-squared association measure are also delineated. Specifically, the developed formulas compute the necessary sample sizes with respect to the considerations of expected confidence interval width and tolerance probability of interval width within a designated value. Supplementary computer programs are provided to aid the implementation of the suggested techniques in practical applications of ANOVA designs when the assumption of homogeneous variances is not tenable.
A comparison of two indices for the intraclass correlation coefficient
(2012-12-01)
Shieh, Gwowen
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管理科學系
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Department of Management Science
In the present study, we examined the behavior of two indices for measuring the intraclass correlation in the one-way random effects model: the prevailing ICC(1) (Fisher, 1938) and the corrected eta-squared (Bliese & Halverson, 1998). These two procedures differ both in their methods of estimating the variance components that define the intraclass correlation coefficient and in their performance of bias and mean squared error in the estimation of the intraclass correlation coefficient. In contrast with the natural unbiased principle used to construct ICC(1), in the present study it was analytically shown that the corrected eta-squared estimator is identical to the maximum likelihood estimator and the pairwise estimator under equal group sizes. Moreover, the empirical results obtained from the present Monte Carlo simulation study across various group structures revealed the mutual dominance relationship between their truncated versions for negative values. The corrected eta-squared estimator performs better than the ICC(1) estimator when the underlying population intraclass correlation coefficient is small. Conversely, ICC(1) has a clear advantage over the corrected eta-squared for medium and large magnitudes of population intraclass correlation coefficient. The conceptual description and numerical investigation provide guidelines to help researchers choose between the two indices for more accurate reliability analysis in multilevel research.
Optimal sample sizes for precise interval estimation of Welch's procedure under various allocation and cost considerations
(2012-03-01)
Shieh, Gwowen
;
Jan, Show-Li
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管理科學系
;
Department of Management Science
Welch's (Biometrika 29: 350-362, 1938) procedure has emerged as a robust alternative to the Student's t test for comparing the means of two normal populations with unknown and possibly unequal variances. To facilitate the advocated statistical practice of confidence intervals and further improve the potential applicability of Welch's procedure, in the present article, we consider exact approaches to optimize sample size determinations for precise interval estimation of the difference between two means under various allocation and cost considerations. The desired precision of a confidence interval is assessed with respect to the control of expected half-width, and to the assurance probability of interval half-width within a designated value. Furthermore, the design schemes in terms of participant allocation and cost constraints include (a) giving the ratio of group sizes, (b) specifying one sample size, (c) attaining maximum precision performance for a fixed cost, and (d) meeting a specified precision level for the least cost. The proposed methods provide useful alternatives to the conventional sample size procedures. Also, the developed programs expand the degree of generality for the existing statistical software packages and can be accessed at brm.psychonomic-journals.org/content/ supplemental.
The impact of ignoring random features of predictor and moderator variables on sample size for precise interval estimation of interaction effects
(2011-12-01)
Shieh, Gwowen
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管理科學系
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Department of Management Science
The influence of the joint distribution of predictor and moderator variables on the identification of interactions has been well described, but the impact on sample size determinations has received rather limited attention within the framework of moderated multiple regression (MMR). This article investigates the deficiency in sample size determinations for precise interval estimation of interaction effects that can result from ignoring the stochastic nature of continuous predictor and moderator variables in MMR. The primary finding of our examinations is that failure to accommodate the distributional properties of regressors can lead to underestimation of the necessary sample size and distortion of the desired interval precision. In order to take account of the randomness of regressor variables, two general and effective procedures for computing sample size estimates are presented. Moreover, corresponding programs are provided to facilitate use of the suggested approaches. This exposition helps to correct drawbacks in the existing techniques and to advance the practice of reporting confidence intervals in MMR analyses.
Optimal sample sizes for Welch's test under various allocation and cost considerations
(2011-12-01)
Jan, Show-Li
;
Shieh, Gwowen
;
管理科學系
;
Department of Management Science
The issue of the sample size necessary to ensure adequate statistical power has been the focus of considerableattention in scientific research. Conventional presentations of sample size determination do not consider budgetary and participant allocation scheme constraints, although there is some discussion in the literature. The introduction of additional allocation and cost concerns complicates study design, although the resulting procedure permits a practical treatment of sample size planning. This article presents exact techniques for optimizing sample size determinations in the context of Welch (Biometrika, 29, 350-362, 1938) test of the difference between two means under various design and cost considerations. The allocation schemes include cases in which (1) the ratio of group sizes is given and (2) one sample size is specified. The cost implications suggest optimally assigning subjects (1) to attain maximum power performance for a fixed cost and (2) to meet adesignated power level for the least cost. The proposed methods provide useful alternatives to the conventional procedures and can be readily implemented with the developed R and SAS programs that are available as supplemental materials from brm.psychonomic-journals.org/content/supplemental.

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