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🏛️國立陽明交通大學機構典藏

Author: search.filters.author.Chen, Yi-ChiehHas files: No

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    Injectable insulin-lysozyme-loaded nanogels with enzymatically-controlled degradation and release for basal insulin treatment: In vitro characterization and in vivo observation
    (2016-02-28)
    Chou, Hao-Syun
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    Larsson, Mikael
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    Hsiao, Meng-Hsuan
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    Chen, Yi-Chieh
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    Roeding, Magnus
    Diabetes is a common global disease that causes immense suffering for individuals and huge costs for the health care system. To minimize complications such as organ degeneration, diabetic patients are required to undergo treatments to maintain the blood glucose level in the normal range, ideally mimicking normal insulin secretion. The normal physiological insulin secretion pattern in healthy individuals consists of a base (basal) level through the day and increased secretion after meals (bolus insulin). Thus effective treatments may combine long acting, low-level insulin therapy with boosts of short acting insulin and/or oral agents. To achieve long term management of basal insulin level, an injectable insulin-loaded gel composed of self-assembled nanoparticles from carboxymethyl-hexanoyl chitosan (CHC) and integrated lysozyme for controlled biodegradation and insulin release was developed. In vitro characterizations and evaluations confirmed that lysozyme was active on CHC and that the amount of lysozyme in a CHC hydrogel determined the degradation and insulin release rate. The degradation products were found to be highly cytocompatible using a cell assay. In vivo evaluation of the system in a diabetic mouse model revealed that the fasted blood glucose level could be maintained in the normal range for 10 days with a single injection of insulin-loaded CHC-lysozyme gel. The insulin-loaded CHC-lysozyme gels clearly show promise for use as a novel injectable long-acting insulin delivery system, with potential to manage the basal insulin level for many days with a single injection. (C) 2015 Elsevier B.V. All rights reserved.
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    Applying FDEM, ERT and GPR at a site with soil contamination: A case study
    (2015-10-01)
    Wang, Tzu-Pin
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    Chen, Chien-Chih
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    Tong, Lun-Tao
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    Chang, Ping-Yu
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    Chen, Yi-Chieh
    This study employed the combination of three methods, namely the Frequency Domain Electromagnetic (FDEM), Electrical Resistivity Tomography (ERT) and Ground Penetrating Radar (GPR) to evaluate a heavy-metal contaminated site for both pre- and post-remediation investigations. The main goals were to verify the position and the integrity of the underground storage tanks (UST), and to determine the effectiveness of remediation to ensure no contaminants remained at the site. In general, the GPR survey was effective at locating shallowly buried objects. However, due to the highly conductive nature of the heavy-metal laden sludge, the GPR signals were attenuated severely. Thus, the first attempt to use GPR in the pre-remediation investigation did not achieve the desired results and other methods were deployed. The existence of the UST and the sludge within were confirmed by ERT and the UST shape was mapped by FDEM. The principal remediation scheme was soil replacement by replacing the contaminated soil with clean silt Based on the distinctive property differences of the contaminated soil and the clean silt, the completion of the remediation was confirmed by the differences between pre-remediation and post-remediation in GPR, ERT and FDEM results. (C) 2015 Elsevier B.V. All rights reserved.