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Exploration of Brain Connectivity during Human Inhibitory Control Using Inter-Trial Coherence
(2020-03-01)
Chikara, Rupesh Kumar
;
Lo, Wei-Cheng
;
Ko, Li-Wei
;
交大名義發表
;
生物科技學系
Inhibitory control is a cognitive process that inhibits a response. It is used in everyday activities, such as driving a motorcycle, driving a car and playing a game. The effect of this process can be compared to the red traffic light in the real world. In this study, we investigated brain connectivity under human inhibitory control using the phase lag index and inter-trial coherence (ITC). The human brain connectivity gives a more accurate representation of the functional neural network. Results of electroencephalography (EEG), the data sets were generated from twelve healthy subjects during left and right hand inhibitions using the auditory stop-signal task, showed that the inter-trial coherence in delta (1-4 Hz) and theta (4-7 Hz) band powers increased over the frontal and temporal lobe of the brain. These EEG delta and theta band activities neural markers have been related to human inhibition in the frontal lobe. In addition, inter-trial coherence in the delta-theta and alpha (8-12 Hz) band powers increased at the occipital lobe through visual stimulation. Moreover, the highest brain connectivity was observed under inhibitory control in the frontal lobe between F3-F4 channels compared to temporal and occipital lobes. The greater EEG coherence and phase lag index in the frontal lobe is associated with the human response inhibition. These findings revealed new insights to understand the neural network of brain connectivity and underlying mechanisms during human response inhibition.
Modulation of the Visual to Auditory Human Inhibitory Brain Network: An EEG Dipole Source Localization Study
(2019-09-01)
Chikara, Rupesh Kumar
;
Ko, Li-Wei
;
交大名義發表
;
生物科技學系
;
生物資訊及系統生物研究所
Auditory alarms are used to direct people's attention to critical events in complicated environments. The capacity for identifying the auditory alarms in order to take the right action in our daily life is critical. In this work, we investigate how auditory alarms affect the neural networks of human inhibition. We used a famous stop-signal or go/no-go task to measure the effect of visual stimuli and auditory alarms on the human brain. In this experiment, go-trials used visual stimulation, via a square or circle symbol, and stop trials used auditory stimulation, via an auditory alarm. Electroencephalography (EEG) signals from twelve subjects were acquired and analyzed using an advanced EEG dipole source localization method via independent component analysis (ICA) and EEG-coherence analysis. Behaviorally, the visual stimulus elicited a significantly higher accuracy rate (96.35%) than the auditory stimulus (57.07%) during inhibitory control. EEG theta and beta band power increases in the right middle frontal gyrus (rMFG) were associated with human inhibitory control. In addition, delta, theta, alpha, and beta band increases in the right cingulate gyrus (rCG) and delta band increases in both right superior temporal gyrus (rSTG) and left superior temporal gyrus (lSTG) were associated with the network changes induced by auditory alarms. We further observed that theta-alpha and beta bands between lSTG-rMFG and lSTG-rSTG pathways had higher connectivity magnitudes in the brain network when performing the visual tasks changed to receiving the auditory alarms. These findings could be useful for further understanding the human brain in realistic environments.

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