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🏛️國立陽明交通大學機構典藏

Author: search.filters.author.Fan, Shih-KangSubject: search.filters.subject.digital microfluidics

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    Integrated digital and analog microfluidics by EWOD and LDEP
    (2006)
    Lin, Yen-Chen
    ;
    Chuang, Kai-Cheng
    ;
    Wang, Tsu-Te
    ;
    Chiu, Cheng-Pu
    ;
    Fan, Shih-Kang
    EWOD (electrowetting-on-dielectric) and LDEP (liquid dielectrophoresis) are investigated to provide digital and analog microfluidic functions on an integrated chip respectively. By altering the frequency of the applied voltage and the surrounding medium of a EWOD device, we found that when using off as surrounding medium and applying an AC signal similar to 100 kHz, liquid column would be drawn and follow the thin connecting lines of the EWOD driving electrodes instead of remaining on top of the center of the EWOD driving electrodes. This new phenomenon is described in this paper and is regarded as a LDEP effect. Three fundamental tools for integrated digital and analog microfluidics are developed, including a digital-to-analog converter, an analog-to-digital converter, and a valve. Combining EWOD and LDEP effects, liquids can be pumped on a virtual channel (analog microfluidics), defined by energized thin LDEP electrode lines, continuously from liquid reservoir or from a digitized droplet (digital microfluidics). On the contrary, liquids on LDEP electrodes (analog microfluldics) can also be pumped on a EWOD electrode and be digitized in droplet forms with precise volumes (digital microfluidics). EWOD and LDEP can be selectively programmed on a single chip, making integrated digital and analog microfluidics a reality.
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    Realizing temperature-controlled digital microfluidic chips with versatile microelectrodes
    (2007)
    Wei, Jen-Hung
    ;
    Hsu, Wen-Syang
    ;
    Fan, Shih-Kang
    ;
    機械工程學系
    ;
    Department of Mechanical Engineering
    Droplet heating and pumping were performed on a versatile microelectrode by selectively applying appropriate electric signals. The designed electrode is in a meander-tine shape and covered by an insulator. On the one hand, when a potential difference is applied along the electrode, power dissipated by the resistance of the electrode causes droplet heating. On the other hand, when an electric field exists across the insulator above the electrode, the charges stored in the capacitor alter the surface wettability and pump droplet. Manipulated droplets were placed between parallel plates with passivated versatile microelectrodes on the bottom plate and a Teflon-coated blank ITO on the top plate. We successfully applied a DC voltage at the two terminals of the meander-tine electrode to heat up the electrode as well as the droplet above. Besides, pumping droplets by EWOD was demonstrated by applying a proper AC voltage between the electrode on the bottom plate and the ITO on the top plate. With the proposed versatile microelectrode design and actuation scheme, heating and EWOD were obtained on an identical electrode. A digital microfluidic chip capable of droplet manipulation by EWOD and droplet heating was presented.