标题: | 以无机分子改质双性机丁聚糖之自组装混成复合材料及其生医特性之研究 Synthesis and Characterization of Inorganically-Modified Amphiphilic Chitosan-Based Hybrid and Its Potentials for Biomedical Uses |
作者: | 刘典谟 Liu Dean-Mo 国立交通大学材料科学与工程学系(所) |
关键字: | 本质几丁聚醣;羧甲基酸-己醯基几丁聚醣;两性几丁聚醣;无机几丁聚醣复合物;自组装;药物释放;溶胶凝胶化学;胶体稳定性;奈米结构;奈米载体;磁控制药物释放;奈米影像;native chitosan;carboxymethyl-hexanoyl chitosan (CHC);amphiphlicchitosan;inorganic-bearing chitosan hybrid;self-assembly;drug delivery;sol-gelchemistry;colloidal stability;nanostructure;nanocapsule;magnetic control drugrelease;nanoimaging |
公开日期: | 2009 |
摘要: | 几丁聚醣(chitosan)为直链多糖体,是广泛应用在医学、药学、化学分离、 环境工程等领域的天然高分子;几丁聚醣具备生物相容性、生物可降解性、 无毒等性质,但是他难溶于中性溶剂,因此限制了其发展潜力。随着合成 化学的进步,将有机官能基作疏水性改质已有效合成两性衍生物,也常运 用作药物载体、组织工程的支架等,现有许多研究在几丁聚醣中加入无机 物,也致力发展有别于一般合成化学、材料化学、胶体化学、医学、生物 科技等想法的创新思维。因此,利用有机无机复合物增加材料效能和特殊 性质也更显重要。本实验室在几丁聚醣的骨架上利用亲水性羧甲基酸 (carboxymethyl)和疏水性己醯基(hexanoyl)作几丁聚醣的双配位基改质,成 功合成出两性几丁聚醣,称作CHC。CHC 可透过自组装形成奈米颗粒或是 中空的奈米微胞,也可控制其尺寸和疏水程度。藉由控制CHC 的化学亲和 力,可以调控包覆不同性质的药物,以用做特殊医疗效果。另外,越来越 多的技术和研究截取无机配位基的优点,制备出多功能复合材料,这也是 此次计画的中心思想。因此,接下来我们将进一步用无机配位基,如矽烷、 氧化铁做分子内改质。值得一提的本实验室已经合成出新的无机两性CHC 复合物,且初步观察到次奈米的形貌结构,我们可以乐观地预期无机CHC 复合物具前瞻性的应用价值,且本研究计画将深入探讨此复合材料的化 学、物理、生医特性并提供一个有效可行的合成方法。 Chitosan, a linear polysaccharide, has been well-known as a natural polymer for numerous applications from medicine, pharmaceutics, chemical separation, to environmental engineering. However, its poor solvency in neutral media and solvents limited its potential applications, even though it has exhibited biocompatibility, non-toxicity, and biodegradability. With the advancement of synthetic chemistry, hydrophobic modification with organic moieties has been employed to form amphiphilic counterpart and has been received great attentions, as for instance, drug carrier and scaffold for tissue engineering. Incorporation of inorganic component into chitosan molecule has recently been studied and has received increasingly attentions over the disciplines from synthetic chemistry, materials chemistry, colloidal science, medicine, and biotechnology, since it has recognized to integrate merits from inorganic and organic counterparts of the resulting hybrids, to further boost desirable properties with enhanced performance. Recently, a dual-ligand modification using hydrophilic carboxymethyl and hydrophobic hexanoyl pedants along the backbone of native chitosan, has been successfully synthesized in our lab and has giving a novel amphiphilc chitosan, termed as CHC, capable of self-assembling from dense nanoparticle to hollow nanocapsules with controllable size and hydrophobicity. They also showed a diverse ability for encapsulating therapeutic agents of various chemical affinity. However, it is more technically desirable and scientifically sound by taking the advantages of inorganic moieties with additional functionalities to the resulting hybrid, and this turns out to be the central issue of this research proposal, where we intend to further move this CHC molecule a step ahead by intramolecular modification with inorganic ligands, such as silanes and iron oxide, and according to our recent preliminary observation, a new class of amphiphilic inorganic-bearing CHC hybrid molecule with unprecedentedly sub-nano morphological structure can be obtained. It is highly anticipated that such an inorganic-bearing CHC molecular hybrid should exhibit new properties that may not be explored before and this research work should pave a new avenue to provide both scientific and technical advantages based on an in-depth understanding the chemical, physical, and biomedical fundamentals of this new hybrid system, associated with its potential (bio)technical applications. |
官方说明文件#: | NSC98-2113-M009-004 |
URI: | http://hdl.handle.net/11536/101561 https://www.grb.gov.tw/search/planDetail?id=1885051&docId=311577 |
显示于类别: | Research Plans |
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