標題: Picogram detection of metal ions by melanin-sensitized piezoelectric sensor
作者: Huang, G. Steven
Wang, Meng-Te
Su, Chia-Wei
Chen, Yu-Shiun
Hong, Meng-Yen
材料科學與工程學系
材料科學與工程學系奈米科技碩博班
Department of Materials Science and Engineering
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
關鍵字: quartz crystal microbalance;melanin;heavy metal;conformational change;circular dichroism;infrared spectroscopy
公開日期: 31-十月-2007
摘要: A heavy metal ion sensor was constructed by cross-linking melanin onto the gold electrode of quartz crystal microbalance (QCM). A mercury ion sensitivity of 518 +/- 37 Hz/ppm was observed, a substantial increase in sensitivity compared to previous reports of 10-50 Hz/ppm with the limit of detection at 5 ppb. Detection of other metal ions including Sn2+, Ge4+, Li+, Zn2+, Cu2+, Bi3+, Co2+, Al3+, Ni2+, Ag+, and Fe3+ were also performed. Unexpectedly, binding of Mn7+, Ph2+, Cd2+, and Cr3+ increased resonant frequencies. The surface profile of melanin thin film upon binding to metal ions was investigated by atomic force microscopy (AFM). Structural change of melanin upon binding to metal ions was characterized by circular dichroism and by infrared spectroscopy. The current study provides the first example of melanin-coated piezoelectric sensor showing high sensitivity and selectivity to metal ions. (c) 2007 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bios.2007.04.011
http://hdl.handle.net/11536/10213
ISSN: 0956-5663
DOI: 10.1016/j.bios.2007.04.011
期刊: BIOSENSORS & BIOELECTRONICS
Volume: 23
Issue: 3
起始頁: 319
結束頁: 325
顯示於類別:期刊論文


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