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dc.contributor.authorHu, Shang-Hsiuen_US
dc.contributor.authorLiu, Ting-Yuen_US
dc.contributor.authorLiu, Dean-Moen_US
dc.contributor.authorChen, San-Yuanen_US
dc.date.accessioned2014-12-08T15:13:29Z-
dc.date.available2014-12-08T15:13:29Z-
dc.date.issued2007-08-28en_US
dc.identifier.issn0168-3659en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jconrel.2007.06.002en_US
dc.identifier.urihttp://hdl.handle.net/11536/10416-
dc.description.abstractMagnetic sponge-like hydrogels (ferrosponges) were fabricated by using an in-situ synthesis of magnetic nanoparticles (MNPs) in the presence of various concentrations of gelatin. The resulting ferrosponges show an interconnected nanopore structure which serves as a reservoir to accommodate therapeutic drugs and the nanoporous networks demonstrate magnetic sensitive behavior under the application of magnetic field. The ferrosponges showed high swelling ratios, together with excellent elasticity and hydrophilicity, allow them to response rapidly to an external magnetic stimulation for fast and repeatable swelling-deswelling (or expansion-contractile) operations. The ferrosponges with lower gelatin concentration exhibited good performance on magnetification. Furthermore, drug release from the ferrosponges is relatively magnetic-sensitive and is dominated by its magnetism and associated interaction between the magnetic nanoparticle and the gelatin matrix under an external magnetic field. Higher MNPs concentration in the ferrosponges exhibited higher degree of magnetic sensitive which is due to stronger interparticle forces. By taking these peculiar magnetic sensitive behaviors of the ferrosponges, a novel drug delivery system can be designed for medical uses. (C) 2007 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectmagneticen_US
dc.subjectsmarten_US
dc.subjectnanoparticlesen_US
dc.subjectspongeen_US
dc.subjectcontrolled drug releaseen_US
dc.titleNano-ferrosponges for controlled drug releaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jconrel.2007.06.002en_US
dc.identifier.journalJOURNAL OF CONTROLLED RELEASEen_US
dc.citation.volume121en_US
dc.citation.issue3en_US
dc.citation.spage181en_US
dc.citation.epage189en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000249594700007-
dc.citation.woscount52-
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