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dc.contributor.authorHuang, Keng-Shiangen_US
dc.contributor.authorLiu, Ming-Kaien_US
dc.contributor.authorWu, Chun-Hanen_US
dc.contributor.authorYen, Yu-Tangen_US
dc.contributor.authorLin, Yu-Chengen_US
dc.date.accessioned2014-12-08T15:13:36Z-
dc.date.available2014-12-08T15:13:36Z-
dc.date.issued2007-08-01en_US
dc.identifier.issn0960-1317en_US
dc.identifier.urihttp://dx.doi.org/10.1088/0960-1317/17/8/003en_US
dc.identifier.urihttp://hdl.handle.net/11536/10504-
dc.description.abstractThis paper describes the generation of monodisperse calcium alginate (Ca-alginate) microcapsules on a microfluidic platform using the commercial optical disk process. Our strategy is based on combining the rapid injection molding process for a cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These emulsions, consisting of 1.5% (w/v) sodium alginate (Na-alginate), are then dripped into a solution containing 20% (w/v) calcium chloride (CaCl2) creating Ca-alginate microparticles in an efficient manner. This paper demonstrates that the size of Ca-alginate microparticles can be controlled from 20 mu m to 50 mu m in diameter with a variation of less than 10%, simply by altering the relative sheath/sample flow rate ratio. Experimental data show that for a given fixed dispersed phase flow (sample flow), the emulsion size decreases as the average flow rate of the continuous phase flow (sheath flow) increases. The proposed microfluidic platform is capable of generating relatively uniform emulsions and has the advantages of active control of the emulsion diameter, a simple and low cost process and a high throughput.en_US
dc.language.isoen_USen_US
dc.titleCalcium alginate microcapsule generation on a microfluidic system fabricated using the optical disk processen_US
dc.typeArticleen_US
dc.identifier.doi10.1088/0960-1317/17/8/003en_US
dc.identifier.journalJOURNAL OF MICROMECHANICS AND MICROENGINEERINGen_US
dc.citation.volume17en_US
dc.citation.issue8en_US
dc.citation.spage1428en_US
dc.citation.epage1434en_US
dc.contributor.department機械工程學系zh_TW
dc.contributor.departmentDepartment of Mechanical Engineeringen_US
dc.identifier.wosnumberWOS:000248776800003-
dc.citation.woscount25-
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