標題: | Scaffold-directed traceless synthesis of tetrahydro-beta-carbolinehydantoins |
作者: | Chen, Chih-Hau Chang, Chia-Mao Chen, Hsia-Yuan Lai, Jin-Ji Sun, Chung-Ming 應用化學系 Department of Applied Chemistry |
公開日期: | 1-Jul-2007 |
摘要: | Pharmacologically interesting tetrahydro-beta-carbolinehydantoins have been prepared through four-step traceless synthesis by a combinatorial approach. Two-arm PEG 1 (MW approximate to 4000) was used as a soluble polymer support and reacted with Fmoc-protected L-tryptophane 2 to form bis-ester 3. The resulting polymer-supported amino ester 3 was deprotected, and amino ester 4 underwent Pictet-Spengler reaction with varoius ketones to form tricyclic indoles 5. The nucleophilic piperidine in the tricyclic indole reacted with isocyanate to generate the urea intermediates and simultaneously intramolecular cyclization to release the target compounds 7 from the support in good yields. |
URI: | http://dx.doi.org/10.1021/cc070035w http://hdl.handle.net/11536/10574 |
ISSN: | 1520-4766 |
DOI: | 10.1021/cc070035w |
期刊: | JOURNAL OF COMBINATORIAL CHEMISTRY |
Volume: | 9 |
Issue: | 4 |
起始頁: | 618 |
結束頁: | 626 |
Appears in Collections: | Articles |
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