標題: | Angiotensin I-Converting enzyme insertion-related genotypes and allele are associated with higher susceptibility of endometriosis and leiomyoma |
作者: | Hsieh, Yao-Yuan Lee, Cheng-Chun Chang, Chi-Chen Wang, Yu-Kuo Yeh, Lian-Shun Lin, Chich-Sheng 生物科技學系 Department of Biological Science and Technology |
關鍵字: | angiotensin I-converting enzyme;ACE;endometriosis;leiomyoma;polymorphism |
公開日期: | 1-七月-2007 |
摘要: | Endometriosis and leiomyoma display features similar to malignancy, requiring neovascularization to proliferation and growth. Altered vascular-related genes might be related to the development of endometriosis and leiomyoma. Polymorphisms of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) genes have been linked with some vascular diseases. This study investigates whether ACE I/D gene polymorphisms could be used as markers of susceptibility in endometriosis and leiomyoma. Women were divided into three groups: (4) endometriosis (n = 125); (2) leiomyoma (n = 120); () normal controls (n = 128). Genomic DNA was obtained from peripheral leukocyte. ACE I/D gene polymorphisms in intron 16 were amplified by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) Genotypes and allelic frequencies in both groups were compared. We observed the genotype distribution and allele frequency of ACE I/ D gene polymorphisms in both groups were significantly different. Proportions of ACE(star)I homozygote/ heterozygote/D homozygote in both groups were: (1) 50.4/24/25.6%; (2) 25/23.33/51.67%; (3) 10.2/ 29.7/60.1%. Proportions of I/D alleles in each group Were: (1) 62.4/37.6%; (2) 36.7/63.3%; (3) 25/75%. We concluded that ACE(star)I/D gene polymorphisms are associated with endometriosis and leiomyoma suspeptibilities. ACE(star)I-related genotypes and allele are strongly related to the occurrence of endometriosis and moderately related to the occurrence of leiomyoma. |
URI: | http://dx.doi.org/10.1002/mrd.20474 http://hdl.handle.net/11536/10581 |
ISSN: | 1040-452X |
DOI: | 10.1002/mrd.20474 |
期刊: | MOLECULAR REPRODUCTION AND DEVELOPMENT |
Volume: | 74 |
Issue: | 7 |
起始頁: | 808 |
結束頁: | 814 |
顯示於類別: | 期刊論文 |