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dc.contributor.authorHung, Yao-Chingen_US
dc.contributor.authorHuang, G. Stevenen_US
dc.contributor.authorLin, Li-Weien_US
dc.contributor.authorHong, Meng-Yenen_US
dc.contributor.authorSe, Pei-Sanen_US
dc.date.accessioned2014-12-08T15:13:43Z-
dc.date.available2014-12-08T15:13:43Z-
dc.date.issued2007-07-01en_US
dc.identifier.issn0278-6915en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.fct.2006.12.017en_US
dc.identifier.urihttp://hdl.handle.net/11536/10610-
dc.description.abstractThe preventive effect of Thea sinensis melanin (TSM) against cisplatin-induced nephrotoxicity was studied on ICR mice. Animals were given 20 mg/kg i.p. of cisplatin, and TSM was injected i.p. in doses 10-40 mg/kg 2 h before intoxication. The protective effects were evidenced by a complete inhibition of the cisplatin-induced elevation of serum Blood Urea nitrogen (BUN), prevention of oxidative stress, and complete blockade of cisplatin-induced elevation of serum creatinine. TSM by itself, however, did not affect the renal functional parameters, including serum BUN and creatinine. Real-time RT-PCR was applied to quantify mRNA levels of cisplatin-treated mouse kidney compared to normal mouse kidney for selected marker genes. Cisplatin treatment increases mRNA levels 40-fold for glutathione-S-transferases (Gstp2), 15-fold for soluble epoxide hydrolase (Ephx1), 15-fold for lipocalin 2 (Lcn2), 9-fold for lysozyme (Lyz), 5-fold for UDP glycosyltransferase 2 (Utg2b), 30-fold for survival motor neuron (Smn1), 30-fold for guanidinoacetate methyltransferase (Gamt), 80-fold for urine retinol binding protein (Rbp4), 60-fold for aminopeptidase N (Apn), 60-fold for cytochrome P450 (Cyp2d18), and 100-fold for ornithine aminotransferase (Oat). Pre-administration of TSM restored normal expression of marker genes for cisplatin-treated mouse kidneys. TSM by itself, however, did not affect the transcription for marker genes. Results obtained demonstrate that TSM pre-administration can prevent the renal toxic effects of cisplatin. (c) 2007 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectTheo sinensis melaninen_US
dc.subjectcisplatinen_US
dc.subjectnephrotoxicityen_US
dc.subjectreal-time RT-PCRen_US
dc.titleThea sinensis melanin prevents cisplatin-induced nephrotoxicity in miceen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fct.2006.12.017en_US
dc.identifier.journalFOOD AND CHEMICAL TOXICOLOGYen_US
dc.citation.volume45en_US
dc.citation.issue7en_US
dc.citation.spage1123en_US
dc.citation.epage1130en_US
dc.contributor.department材料科學與工程學系奈米科技碩博班zh_TW
dc.contributor.departmentGraduate Program of Nanotechnology , Department of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000247537800004-
dc.citation.woscount13-
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