完整後設資料紀錄
DC 欄位語言
dc.contributor.authorTung, Chi-Huaen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.date.accessioned2014-12-08T15:13:44Z-
dc.date.available2014-12-08T15:13:44Z-
dc.date.issued2007-07-01en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://dx.doi.org/10.1093/nar/gkm288en_US
dc.identifier.urihttp://hdl.handle.net/11536/10618-
dc.description.abstractThe fastSCOP is a web server that rapidly identifies the structural domains and determines the evolutionary superfamilies of a query protein structure. This server uses 3D-BLAST to scan quickly a large structural classification database (SCOP1.71 with <95% identity with each other) and the top 10 hit domains, which have different superfamily classifications, are obtained from the hit lists. MAMMOTH, a detailed structural alignment tool, is adopted to align these top 10 structures to refine domain boundaries and to identify evolutionary superfamilies. Our previous works demonstrated that 3D-BLAST is as fast as BLAST, and has the characteristics of BLAST (e.g. a robust statistical basis, effective search and reliable database search capabilities) in large structural database searches based on a structural alphabet database and a structural alphabet substitution matrix. The classification accuracy of this server is similar to 98% for 586 query structures and the average execution time is similar to 5. This server was also evaluated on 8700 structures, which have no annotations in the SCOP; the server can automatically assign 7311 (84%) proteins (9420 domains) to the SCOP superfamilies in 9.6 h. These results suggest that the fastSCOP is robust and can be a useful server for recognizing the evolutionary classifications and the protein functions of novel structures. The server is accessible at http://fastSCOP.life.nctu.edu.tw.en_US
dc.language.isoen_USen_US
dc.titlefastSCOP: a fast web server for recognizing protein structural domains and SCOP superfamiliesen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/nar/gkm288en_US
dc.identifier.journalNUCLEIC ACIDS RESEARCHen_US
dc.citation.volume35en_US
dc.citation.issueen_US
dc.citation.spageW438en_US
dc.citation.epageW443en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000255311500083-
dc.citation.woscount11-
顯示於類別:期刊論文


文件中的檔案:

  1. 000255311500083.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。