標題: | The effect of centaurein on interferon-gamma expression and Listeria infection in mice |
作者: | Chang, Shu-Lin Yeh, Hsu-Hua Lin, Yu-Shiun Chiang, Yi-Ming Wu, Tung-Kung Yang, Wen-Chin 生物科技學系 Department of Biological Science and Technology |
關鍵字: | centaurein;IFN-gamma;Listeria;flavonoid |
公開日期: | 15-二月-2007 |
摘要: | We previously found that centaurein enhanced IFN-gamma transcription in T cells. Here, we demonstrate that centaurein increased the IFN-gamma expression in T and NK cells and the serum IFN-gamma level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-gamma but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-gamma expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-gamma expression. (c) 2006 Elsevier Inc. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.taap.2006.11.026 http://hdl.handle.net/11536/11128 |
ISSN: | 0041-008X |
DOI: | 10.1016/j.taap.2006.11.026 |
期刊: | TOXICOLOGY AND APPLIED PHARMACOLOGY |
Volume: | 219 |
Issue: | 1 |
起始頁: | 54 |
結束頁: | 61 |
顯示於類別: | 期刊論文 |