標題: Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation
作者: Pan, Chun-Hsu
Lin, Jiunn-Lee
Lai, Ling-Ping
Chen, Chien-Lung
Huang, Shoei K. Stephen
Lin, Chih-Sheng
生物科技學系
Department of Biological Science and Technology
關鍵字: angiotensin converting enzyme II;atrial fibrillation;fibrosis;extracellular signal-regulated kinase;renin-angiotensin system
公開日期: 6-二月-2007
摘要: Atrial fibrillation (AF), the most common cardiac arrhythmia, is frequently accompanied by atrial interstitial fibrosis. Angiotensin II (Ang II) dependent signaling pathways have been implicated in interstitial fibrosis during the development of AF. However, Ang II could be further degraded by angiotensin converting enzyme II (ACE2). We examined expression of ACE2 in the fibrillating atria of pigs and its involvement in fibrotic pathogenesis during AF. Nine adult pigs underwent continuous rapid atrial pacing to induce sustained AF and six pigs were sham controls (i.e., sinus rhythm; SR). In the histological examinations, extensive accumulation of extracellular matrix in the interstitial space of the atria, as evidenced by Masson's trichrome stain, were found in fibrillating atria. The relative amount of collagen type I in the atria with AF was significantly increased as compared with that in the SR. Local ACE activity in the fibrillating atria was also markedly higher than that in the SR subjects. ACE2 gene and protein expression in the AF subjects were significantly decreased compared with those in the SR subjects, whereas expression of mitogen-activated/ERK kinase 1/2 (MEK1/2), extracellular signal-regulated protein kinase 2 (ERK2), and activated ERK2 were significantly greater in the AF subjects. We propose that decreasing ACE2 expression during AF may affect the Ang II-dependent signaling pathway. In addition, our results suggest that atrial fibrosis in AF may be induced by antagonistic regulation between ACE and ACE2 expression. (c) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
URI: http://dx.doi.org/10.1016/j.febslet.2007.01.014
http://hdl.handle.net/11536/11138
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2007.01.014
期刊: FEBS LETTERS
Volume: 581
Issue: 3
起始頁: 526
結束頁: 534
顯示於類別:期刊論文


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