標題: Simultaneous identifications of the minimum effective dose in each of several groups
作者: Jan, Show-Li
Chen, Yuh-Ing
Shieh, Gwowen
交大名義發表
National Chiao Tung University
關鍵字: dose-response study;Helmert contrasts;pairwise contrasts;simultaneous inference;step-down closed test
公開日期: 1-Feb-2007
摘要: One primary goal in dose-response studies for drug development is to identify the minimum effective dose (MED) which is the lowest dose level with an effect that exceeds that of the zero dose control. In this paper, we consider step-down closed testing procedures on the basis of pairwise and Helmert contrasts suggested by Tamhane et al. [ Tamhane, A. C., Hochberg, Y., and Dunnett, C. W., 1996, Multiple test procedures for dose finding. Biometrics, 52, 21 - 37.] for the situation where one wishes to make all such MED identifications simultaneously in each of several groups. An example is given to illustrate the proposed tests. The Monte Carlo studies are further implemented to compare the relative error rate and power performances of the proposed tests.
URI: http://dx.doi.org/10.1080/10629360600565038
http://hdl.handle.net/11536/11197
ISSN: 0094-9655
DOI: 10.1080/10629360600565038
期刊: JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
Volume: 77
Issue: 2
起始頁: 149
結束頁: 161
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