標題: Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats
作者: Tsai, Meng-Hsiun
Huang, G. Steven
Hung, Yao-Ching
Bin, Liu
Liao, Lung-Te
Lin, Li-Wei
材料科學與工程學系奈米科技碩博班
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
關鍵字: Psoralea corylifolia;ovariectomized;osteoporosis
公開日期: 2007
摘要: We evaluated the protective effect of Psoralea corylifolia L. (PCL) extract on the ovariectomized (OVX) rat model. The biochemical markers of bone turnover, calcium metabolism, and calcium balance were examined. PCL extract (25 mg or 50 mg/kg body weight/day) was orally administrated to OVX rats for 3 months. PCL extract did not alter weight gain or uterus weight in OVX rats. PCL extract significantly increased serum Ca (calcium) levels (p < 0.05, vs. OVX group) as well as decreased urinary Ca excretion (p < 0.05, vs. OVX group) in OVX rats. The upregulation of serum osteocalcin level by ovariectomy was suppressed by treatment with PCL extract in rats (p < 0.05, vs. OVX group). PCL extract increased bone mineral density at 50 mg/kg body weight/day in OVX rats (p < 0.05, vs. OVX group). Our results indicate that orally administrated PCL extract can decrease urinary calcium excretion and decrease serum osteocalcin in OVX rats, resulting in positive effects on bone mineral density as well as bone formation. In conclusion, our studies showed that PCL might be a potential candidate for treatment of postmenopausal osteoporosis.
URI: http://hdl.handle.net/11536/11289
http://dx.doi.org/10.1142/S0192415X07005168
ISSN: 0192-415X
DOI: 10.1142/S0192415X07005168
期刊: AMERICAN JOURNAL OF CHINESE MEDICINE
Volume: 35
Issue: 4
起始頁: 669
結束頁: 680
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