Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Wang, Jang-Shiun | en_US |
dc.contributor.author | Yang, Yun-Liang | en_US |
dc.contributor.author | Wu, Chin-Jung | en_US |
dc.contributor.author | Ouyang, Karen J. | en_US |
dc.contributor.author | Tseng, Kuo-Yun | en_US |
dc.contributor.author | Chen, Chia-Geun | en_US |
dc.contributor.author | Wang, Hsin | en_US |
dc.contributor.author | Lo, Hsiu-Jung | en_US |
dc.date.accessioned | 2014-12-08T15:15:40Z | - |
dc.date.available | 2014-12-08T15:15:40Z | - |
dc.date.issued | 2006-10-01 | en_US |
dc.identifier.issn | 0022-2615 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1099/jmm.0.46650-0 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/11698 | - |
dc.description.abstract | CaNdt80p, the Candida albicans homologue of the Saccharomyces cerevisiae transcription factor ScNdt80p, has been identified as a positive regulator of CDR1, which encodes an eff lux pump involved in drug resistance in C. albicans. To investigate the involvement of the putative DNA-binding domain of CaNdt80p in drug resistance, chimeras of CaNdt80p and ScNdt80p were constructed. Interestingly, the DNA-binding domain of ScNdt80p could functionally complement that of CaNdt80p to activate CDR1p-lacZ in S. cerevisiae. Consistently, CaNdt80p containing a mutation in the DNA-binding domain failed to activate CDR1p-lacZ in S. cerevisiae. Furthermore, a copy of CaNDT80 with the same mutation also failed to complement the drug-sensitive phenotype caused by a null mutation in C. albicans. Thus, the DNA-binding domain of CaNdt80p is critical for its function in drug resistance in C. albicans. | en_US |
dc.language.iso | en_US | en_US |
dc.title | The DNA-binding domain of CaNdt80p is required to activate CDR1 involved in drug resistance in Candida albicans | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1099/jmm.0.46650-0 | en_US |
dc.identifier.journal | JOURNAL OF MEDICAL MICROBIOLOGY | en_US |
dc.citation.volume | 55 | en_US |
dc.citation.issue | 10 | en_US |
dc.citation.spage | 1403 | en_US |
dc.citation.epage | 1411 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.identifier.wosnumber | WOS:000241644000015 | - |
dc.citation.woscount | 7 | - |
Appears in Collections: | Articles |