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dc.contributor.authorLiu, Tse-Yingen_US
dc.contributor.authorLiu, Ting-Yuen_US
dc.contributor.authorChen, San-Yuanen_US
dc.contributor.authorChen, Shian-Chuanen_US
dc.contributor.authorLiu, Dean-Moen_US
dc.date.accessioned2014-12-08T15:15:50Z-
dc.date.available2014-12-08T15:15:50Z-
dc.date.issued2006-09-01en_US
dc.identifier.issn1533-4880en_US
dc.identifier.urihttp://dx.doi.org/10.1166/jnn.2006.458en_US
dc.identifier.urihttp://hdl.handle.net/11536/11810-
dc.description.abstractIn order to explore the effect of nanofiller on the regulation of the drug release behavior from micro sphere-embedded hydrogel prepared by carboxymethyl-hexanoyl chitosan (HNOCC) and O-hexanoyl chitosan (OHC), the release kinetics was investigated in terms of various amounts of calcium-deficient hydroxyapatite (CDHA) nanoparticles incorporated. HNOCC is a novel chitosan-based hydrophilic matrix with a burst release profile in a highly swollen state. The drug release kinetics of the HNOCC hydrogel can be regulated by incorporation of well-dispersed CDHA nanoparticles. It was found that the release duration of ibuprofen (IBU) from HNOCC was prolonged with increasing amounts of CDHA which acts as a crosslink agent and diffusion barrier. On the contrary, the release duration of the IBU from OHC (hydrophobic phase) was shortened through increasing the CDHA amount over 5%, which is due to the hydrophilic nature of the CDHA nanoparticles destroying the intermolecular hydrophobic interaction and accelerating OHC degradation. Thus, water accessibility and molecular relaxation were enhanced, resulting in a higher release rate. In addition, sustained and sequential release behavior was achieved by embedding the OHC microspheres (hydrophobic phase) into the HNOCC (hydrophilic phase) matrix, which could significantly prolong the release duration of the HNOCC drug-loaded implant.en_US
dc.language.isoen_USen_US
dc.subjectamphiphilic hydrogelen_US
dc.subjectcarboxymethyl-hexanoyl chitosanen_US
dc.subjecthydrogel-based implanten_US
dc.subjectO-hexanoyl chitosanen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug releaseen_US
dc.titleEffect of hydroxyapatite nanoparticles on ibuprofen release from carboxymethyl-hexanoyl chitosan/O-hexanoyl chitosan hydrogelen_US
dc.typeArticle; Proceedings Paperen_US
dc.identifier.doi10.1166/jnn.2006.458en_US
dc.identifier.journalJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGYen_US
dc.citation.volume6en_US
dc.citation.issue9-10en_US
dc.citation.spage2929en_US
dc.citation.epage2935en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000240865900033-
Appears in Collections:Conferences Paper