標題: The physiological changes of cumulative hemorrhagic shock in conscious rats
作者: Peng, TC
Liao, KW
Lai, HL
Chao, YFC
Chang, FM
Harn, HJ
Lee, RP
生物科技學系
Department of Biological Science and Technology
關鍵字: animal model;conscious rats;cumulative hemorrhage;lactic acid;organ injury;unrestrained
公開日期: 1-五月-2006
摘要: Hemorrhagic shock is a common cause of death in emergency rooms. Current animal models of hemorrhage encounter a major problem that the volume and the rate of blood loss cannot be controlled. In addition, the use of anesthesia obscures physiological responses. Our experiments were designed to establish an animal model based on the clinical situation for studying hemorrhagic shock. Hemorrhagic shock was induced by withdrawing blood from a femoral arterial catheter. The blood volume withdrawn was 40% of the total blood volume for group 1 and 30% for group 2 and 3. Group 3 was anesthetized with sodium pentobarbital ( 25 mg/ kg, i. v.) at the beginning of blood withdrawal. Our data showed that the survival rate was 87.5% at 48 h in the conscious group and 0% at 9 h in anesthetic group after hemorrhage. The levels of mean arterial pressure, heart rate, white blood count, TNF-alpha, IL1-beta, CPK, and LDH after blood withdrawal in the anesthetic group were generally lower than those in conscious groups. These results indicated that anesthetics significantly affected the physiology of experimental animals. The conscious, unrestrained and cumulative volume- controlled hemorrhagic shock model was a good experimental model to investigate the physical phenomenon without anesthetic interfernce.
URI: http://dx.doi.org/10.1007/s11373-005-9065-3
http://hdl.handle.net/11536/12326
ISSN: 1021-7770
DOI: 10.1007/s11373-005-9065-3
期刊: JOURNAL OF BIOMEDICAL SCIENCE
Volume: 13
Issue: 3
起始頁: 385
結束頁: 394
顯示於類別:期刊論文


文件中的檔案:

  1. 000237502100010.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。