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dc.contributor.authorPeng, TCen_US
dc.contributor.authorLiao, KWen_US
dc.contributor.authorLai, HLen_US
dc.contributor.authorChao, YFCen_US
dc.contributor.authorChang, FMen_US
dc.contributor.authorHarn, HJen_US
dc.contributor.authorLee, RPen_US
dc.date.accessioned2014-12-08T15:16:45Z-
dc.date.available2014-12-08T15:16:45Z-
dc.date.issued2006-05-01en_US
dc.identifier.issn1021-7770en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s11373-005-9065-3en_US
dc.identifier.urihttp://hdl.handle.net/11536/12326-
dc.description.abstractHemorrhagic shock is a common cause of death in emergency rooms. Current animal models of hemorrhage encounter a major problem that the volume and the rate of blood loss cannot be controlled. In addition, the use of anesthesia obscures physiological responses. Our experiments were designed to establish an animal model based on the clinical situation for studying hemorrhagic shock. Hemorrhagic shock was induced by withdrawing blood from a femoral arterial catheter. The blood volume withdrawn was 40% of the total blood volume for group 1 and 30% for group 2 and 3. Group 3 was anesthetized with sodium pentobarbital ( 25 mg/ kg, i. v.) at the beginning of blood withdrawal. Our data showed that the survival rate was 87.5% at 48 h in the conscious group and 0% at 9 h in anesthetic group after hemorrhage. The levels of mean arterial pressure, heart rate, white blood count, TNF-alpha, IL1-beta, CPK, and LDH after blood withdrawal in the anesthetic group were generally lower than those in conscious groups. These results indicated that anesthetics significantly affected the physiology of experimental animals. The conscious, unrestrained and cumulative volume- controlled hemorrhagic shock model was a good experimental model to investigate the physical phenomenon without anesthetic interfernce.en_US
dc.language.isoen_USen_US
dc.subjectanimal modelen_US
dc.subjectconscious ratsen_US
dc.subjectcumulative hemorrhageen_US
dc.subjectlactic aciden_US
dc.subjectorgan injuryen_US
dc.subjectunrestraineden_US
dc.titleThe physiological changes of cumulative hemorrhagic shock in conscious ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s11373-005-9065-3en_US
dc.identifier.journalJOURNAL OF BIOMEDICAL SCIENCEen_US
dc.citation.volume13en_US
dc.citation.issue3en_US
dc.citation.spage385en_US
dc.citation.epage394en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000237502100010-
dc.citation.woscount17-
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