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dc.contributor.authorChiu, Shih-Haoen_US
dc.contributor.authorUrban, Pawel L.en_US
dc.date.accessioned2015-07-21T08:29:37Z-
dc.date.available2015-07-21T08:29:37Z-
dc.date.issued2015-02-15en_US
dc.identifier.issn0956-5663en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bios.2014.08.087en_US
dc.identifier.urihttp://hdl.handle.net/11536/123846-
dc.description.abstractMass spectrometry (MS) is an important analytical technique with numerous applications in clinical analysis, biochemistry, environmental analysis, geology and physics. Its success builds on the ability of MS to determine molecular weights of analytes, and elucidate their structures. However, sample handling prior to MS requires a lot of attention and labor. In this work we were aiming to automate processing samples for MS so that analyses could be conducted without much supervision of experienced analysts. The goal of this study was to develop a robotics and information technology-oriented platform that could control the whole analysis process including sample delivery, reaction-based assay, data acquisition, and interaction with the analyst. The proposed platform incorporates a robotic arm for handling sample vials delivered to the laboratory, and several auxiliary devices which facilitate and secure the analysis process. They include: multi-relay board, infrared sensors, photo-interrupters, gyroscopes, force sensors, fingerprint scanner, barcode scanner, touch screen panel, and internet interface. The control of all the building blocks is achieved through implementation of open-source electronics (Arduino), and enabled by custom-written programs in C language. The advantages of the proposed system include: low cost, simplicity, small size, as well as facile automation of sample delivery and processing without the intervention of the analyst. It is envisaged that this simple robotic system may be the forerunner of automated laboratories dedicated to mass spectrometric analysis of biological samples. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectArduinoen_US
dc.subjectAutomationen_US
dc.subjectMass spectrometryen_US
dc.subjectOpen-source electronicsen_US
dc.subjectRoboticsen_US
dc.subjectSample handlingen_US
dc.titleRobotics-assisted mass spectrometry assay platform enabled by open-source electronicsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bios.2014.08.087en_US
dc.identifier.journalBIOSENSORS & BIOELECTRONICSen_US
dc.citation.volume64en_US
dc.citation.spage260en_US
dc.citation.epage268en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.department應用化學系分子科學碩博班zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.contributor.departmentInstitute of Molecular scienceen_US
dc.identifier.wosnumberWOS:000345059100039en_US
dc.citation.woscount1en_US
Appears in Collections:Articles