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dc.contributor.authorLin, Chun-Yuen_US
dc.contributor.authorLee, Chien-Hsingen_US
dc.contributor.authorChang, Yu-Weien_US
dc.contributor.authorWang, Hui-Minen_US
dc.contributor.authorChen, Chung-Yien_US
dc.contributor.authorChen, Yen-Hsuen_US
dc.date.accessioned2015-07-21T11:21:12Z-
dc.date.available2015-07-21T11:21:12Z-
dc.date.issued2014-12-01en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://dx.doi.org/10.3390/ijms151222819en_US
dc.identifier.urihttp://hdl.handle.net/11536/124096-
dc.description.abstractInflammation is a serious health issue worldwide that induces many diseases such as sepsis. There has been a vast search for potentially effective drugs to decrease mortality from sepsis. Pheophytin a is a chlorophyll-related compound derived from green tea. We found that pre-treatment with pheophytin a suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1 beta in RAW 264.7 macrophages. NO synthase-2 (NOS2) and cyclooxygenase-2 (COX-2) expression levels were repressed by pre-treatment with pheophytin a at both the transcriptional and translational levels. Pheophytin a inhibited NOS2 promoter activity, but not its mRNA stability, through extracellular signal-regulated kinase (ERK1/2). This suppression was reversed by ERK1/2 inhibitor (U0126). Pheophytin a reduced signal transducers and activators of transcription 1 (STAT-1) activation, without an obvious influence on activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B). These results suggest that pheophytin a functions by down-regulating the transcriptional levels of inflammatory mediators and blocking the ERK and STAT-1 pathways.en_US
dc.language.isoen_USen_US
dc.subjectpheophytin aen_US
dc.subjectNOen_US
dc.subjectsignal transducers and activators of transcription 1 (STAT-1)en_US
dc.subjectanti-inflammationen_US
dc.titlePheophytin a Inhibits Inflammation via Suppression of LPS-Induced Nitric Oxide Synthase-2, Prostaglandin E2, and Interleukin-1 beta of Macrophagesen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms151222819en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESen_US
dc.citation.volume15en_US
dc.citation.issue12en_US
dc.citation.spage22819en_US
dc.citation.epage22834en_US
dc.contributor.department生醫工程研究所zh_TW
dc.contributor.departmentInstitute of Biomedical Engineeringen_US
dc.identifier.wosnumberWOS:000346797400075en_US
dc.citation.woscount0en_US
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