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dc.contributor.authorMa, Nianhanen_US
dc.contributor.authorLai, Ching-Shuen_US
dc.contributor.authorChung, Chih-Hanen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.contributor.authorHsu, Kai-Chengen_US
dc.contributor.authorChen, Chin-Yuen_US
dc.contributor.authorChung, Tao-Shengen_US
dc.contributor.authorLi, Shimingen_US
dc.contributor.authorHo, Chi-Tangen_US
dc.contributor.authorPan, Min-Hsiungen_US
dc.date.accessioned2015-07-21T11:20:33Z-
dc.date.available2015-07-21T11:20:33Z-
dc.date.issued2014-11-01en_US
dc.identifier.issn1756-4646en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jff.2014.08.009en_US
dc.identifier.urihttp://hdl.handle.net/11536/124127-
dc.description.abstract5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this study, we investigated the anti-tumor promoting effect and underlying molecular mechanism of 5-DTAN on 7,12-dimethyl-benz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis. Application of 5-DTAN prior to each TPA-treatment was more effective than that of TAN on reducing the number, incidence and size of papillomas in DMBA-initiated mouse skin. Moreover, 5-DTAN suppressed cyclooxygenase-2 (COX-2) protein expression more strongly than TAN through interfering with phosphatidylinositiol 3-kinase (PI3K)/Akt signaling and further activation of transcription factor NF-kappa B. Taken together, these results revealed for the first time the in vivo chemopreventive efficacy of 5-DTAN on inhibition of skin carcinogenesis through promoting apoptosis and molecular interactions with residues of PI3K, COX-2, and AKT that may potentially serve as a novel functional agent capable of preventing inflammation-associated tumorigenesis. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subject5-Demethyltangeretinen_US
dc.subjectTangeretinen_US
dc.subjectDMBAen_US
dc.subjectTPAen_US
dc.subjectInflammationen_US
dc.title5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesisen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jff.2014.08.009en_US
dc.identifier.journalJOURNAL OF FUNCTIONAL FOODSen_US
dc.citation.volume11en_US
dc.citation.spage528en_US
dc.citation.epage537en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000346885500053en_US
dc.citation.woscount1en_US
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