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dc.contributor.authorLin, Chien Y.en_US
dc.contributor.authorHuang, Jung Y.en_US
dc.contributor.authorLo, Leu-Weien_US
dc.date.accessioned2015-07-21T08:29:09Z-
dc.date.available2015-07-21T08:29:09Z-
dc.date.issued2015-03-01en_US
dc.identifier.issn0005-2736en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbamem.2014.12.019en_US
dc.identifier.urihttp://hdl.handle.net/11536/124314-
dc.description.abstractEpidermal growth factor receptor (EGFR/ErbB1) is a transmembrane protein that can drive cell growth and survival via the ligand-induced dimerization of receptors. Because dimerization is a common mechanism for signal transduction, it is important to improve our understanding of how the dimerization process and membrane structure regulate signal transduction. In this study, we examined the effect of lipid nanodomains on the dimerization process of EGFR molecules. We discovered that after ligand binding, EGFR molecules may move into lipid nanodomains. The lipid nanodomains surrounding two liganded EGFRs can merge during their correlated motion. The transition rates between different diffusion states of liganded EGFR molecules are regulated by the lipid domains. Our method successfully captures both the sensitivity of single-molecule processes and statistic accuracy of data analysis, providing insight into the connection between the mobile clustering process of receptors and the hierarchical structure of plasma membrane. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectSingle-moleculeen_US
dc.subjectReceptoren_US
dc.subjectDiffusionen_US
dc.titleUnraveling the impact of lipid domains on the dimerization processes of single-molecule EGFRs of live cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbamem.2014.12.019en_US
dc.identifier.journalBIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANESen_US
dc.citation.volume1848en_US
dc.citation.spage886en_US
dc.citation.epage893en_US
dc.contributor.department光電工程學系zh_TW
dc.contributor.departmentDepartment of Photonicsen_US
dc.identifier.wosnumberWOS:000349582500016en_US
dc.citation.woscount0en_US
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