標題: Chitosan-PEG Hydrogel with Sol-Gel Transition Triggerable by Multiple External Stimuli
作者: Tsao, Ching Ting
Hsiao, Meng Hsuan
Zhang, Mengying Y.
Levengood, Sheeny Lan
Zhang, Miqin
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: biocompatible;chitosan;hydrogels;poly(ethylene glycol);smart gels
公開日期: 12-Feb-2015
摘要: Smart hydrogels play an increasingly important role in biomedical applications, since materials that are both biocompatible and multi-stimuli-responsive are highly desirable. A simple, organic solvent-free method is presented to synthesize a biocompatible hydrogel that undergoes a sol-gel transition in response to multiple stimuli. Methoxy-poly(ethylene glycol) (mPEG) is modified into carboxylic-acid-terminated-methoxy-poly(ethylene glycol) (mPEG-acid), which is then grafted onto chitosan via amide linkages yielding mPEG-g-chitosan. Grafting of mPEG onto hydrophobic chitosan imparts hydrophilic properties to the resultant polymer. The mPEG-g-chitosan gel exhibits a controllable multi-stimuli-responsive property. The balance between hydrophilicity and hydrophobicity is believed to confer mPEG-g-chitosan with stimuli-responsive behavior. The effect of salt concentration, solute concentration, temperature, and pH on the sol-gel transition of mPEG-g-chitosan is evaluated and the underlying mechanisms of mPEG-g-chitosan polymer packing and gelation property is discussed.
URI: http://dx.doi.org/10.1002/marc.201400586
http://hdl.handle.net/11536/124329
ISSN: 1022-1336
DOI: 10.1002/marc.201400586
期刊: MACROMOLECULAR RAPID COMMUNICATIONS
Volume: 36
起始頁: 332
結束頁: 338
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