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dc.contributor.authorLai, Hong-Zhengen_US
dc.contributor.authorChen, Wei-Yuen_US
dc.contributor.authorWu, Ching-Yien_US
dc.contributor.authorChen, Yu-Chieen_US
dc.date.accessioned2015-07-21T08:28:53Z-
dc.date.available2015-07-21T08:28:53Z-
dc.date.issued2015-01-28en_US
dc.identifier.issn1944-8244en_US
dc.identifier.urihttp://dx.doi.org/10.1021/am507919men_US
dc.identifier.urihttp://hdl.handle.net/11536/124364-
dc.description.abstractAntibiotic-resistant bacteria have emerged because of the prevalent use of antibacterial agents. Thus, new antibacterial agents and therapeutics that can treat bacterial infections are necessary. Vancomycin is a potent antibiotic. Unfortunately, some bacterial strains have developed their resistance toward vancomycin. Nevertheless, it has been demonstrated that vancomycin-immobilized nanoparticles (NPs) are capable to be used in inhibition of the cell growth of vancomycin-resistant bacterial strains through multivalent interactions. However, multistep syntheses are usually necessary to generate vancomycin-immobilized NPs. Thus, maintaining the antibiotic activity of vancomycin when the drug is immobilized on the surface of NPs is challenging. In this study, a facile approach to generate vancomycin immobilized gold (Van-Au) NPs through one-pot stirring of vancomycin with aqueous tetrachloroauric acid at pH 12 and 25 degrees C for 24 h was demonstrated. Van-Au NPs (8.4 +/- 1.3 nm in size) were readily generated. The generated Van-Au NPs maintained their antibiotic activities and inhibited the cell growth of pathogens, which included Gram-positive and Gram-negative bacteria as well as antibiotic-resistant bacterial strains. Furthermore, the minimum inhibitory concentration of the Van-Au NPs against bacteria was lower than that of free-form vancomycin. Staphylococcus aureus-infected macrophages were used as the model samples to examine the antibacterial activity of the Van-Au NPs. Macrophages have the tendency to engulf Van-Au NPs through endocytosis. The results showed that the cell growth of S. aureus in the macrophages was effectively inhibited, suggesting the potential of using the generated Van-Au NPs as antibacterial agents for bacterial infectious diseases.en_US
dc.language.isoen_USen_US
dc.subjectpathogenic bacteriaen_US
dc.subjectantibioticsen_US
dc.subjectgold nanoparticlesen_US
dc.subjectvancomycinen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectmacrophageen_US
dc.titlePotent Antibacterial Nanoparticles for Pathogenic Bacteriaen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/am507919men_US
dc.identifier.journalACS APPLIED MATERIALS & INTERFACESen_US
dc.citation.spage2046en_US
dc.citation.epage2054en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000348688700080en_US
dc.citation.woscount0en_US
Appears in Collections:Articles