標題: | Ndt80p is involved in L-sorbose utilization through regulating SOU1 in Candida albicans |
作者: | Lo, Hsiu-Jung Chu, Wen-Li Liou, Ci-Hong Huang, Szu-Hsuan Khoo, Kay-Hooi Yang, Yun-Liang 生物科技學系 分子醫學與生物工程研究所 Department of Biological Science and Technology Institute of Molecular Medicine and Bioengineering |
關鍵字: | Yeast;2D-PAGE analysis;NDT80;Candida |
公開日期: | 1-一月-2015 |
摘要: | Ndt80p, a known transcriptional factor, regulates various targets involved in stress responses, filamentous growth, and virulence in Candida albicans. Potential targets of Ndt80p have been identified at the transcriptional level. The present study was conducted to identify genes regulated by Ndt80p from the protein level. We found that the levels of Ahp1p, Fma1p, Hsp21p, Rfa2p, Snz1p, Sod1p, Soul p, Trp99p, orf19.251, orf19.1862, and orf19.5620, were affected by the null mutation of NDT80 by two-dimensional polyacrylamide gel-electrophoresis analysis. Among the 11 proteins, all but Sou1p and Rfa2p are suggested to be involved in known functions of Ndt80p. Here, we demonstrate that Ndt80p plays a role in t-sorbose utilization through regulating SOU1 in C. albicans. (C) 2014 Elsevier GmbH. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.ijmm.2014.11.001 http://hdl.handle.net/11536/124412 |
ISSN: | 1438-4221 |
DOI: | 10.1016/j.ijmm.2014.11.001 |
期刊: | INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY |
Volume: | 305 |
起始頁: | 170 |
結束頁: | 173 |
顯示於類別: | 期刊論文 |