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dc.contributor.authorChen, Feng-Chien_US
dc.date.accessioned2019-04-03T06:41:38Z-
dc.date.available2019-04-03T06:41:38Z-
dc.date.issued2015-01-01en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://dx.doi.org/10.3390/ijms16010452en_US
dc.identifier.urihttp://hdl.handle.net/11536/124413-
dc.description.abstractAlternative RNA structures (ARSs), or alternative transcript isoforms, are critical for regulating cellular phenotypes in humans. In addition to generating functionally diverse protein isoforms from a single gene, ARS can alter the sequence contents of 5'/3' untranslated regions (UTRs) and intronic regions, thus also affecting the regulatory effects of these regions. ARS may introduce premature stop codon(s) into a transcript, and render the transcript susceptible to nonsense-mediated decay, which in turn can influence the overall gene expression level. Meanwhile, ARS can regulate the presence/absence of upstream open reading frames and microRNA targeting sites in 5'UTRs and 3'UTRs, respectively, thus affecting translational efficiencies and protein expression levels. Furthermore, since ARS may alter exon-intron structures, it can influence the biogenesis of intronic microRNAs and indirectly affect the expression of the target genes of these microRNAs. The connections between ARS and multiple regulatory mechanisms underline the importance of ARS in determining cell fate. Accumulating evidence indicates that ARS-coupled regulations play important roles in tumorigenesis. Here I will review our current knowledge in this field, and discuss potential future directions.en_US
dc.language.isoen_USen_US
dc.subjectgene regulationen_US
dc.subjectalternative splicingen_US
dc.subjectalternative promoter usageen_US
dc.subjectalternative cleavage and polyadenylationen_US
dc.subjectuntranslated regionen_US
dc.subjectnonsense-mediated decayen_US
dc.subjectupstream open reading frameen_US
dc.subjectinternal ribosome entry siteen_US
dc.subjectmicroRNAen_US
dc.subjecttumorigenesisen_US
dc.titleAlternative RNA Structure-Coupled Gene Regulations in Tumorigenesisen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms16010452en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESen_US
dc.citation.volume16en_US
dc.citation.issue1en_US
dc.citation.spage452en_US
dc.citation.epage475en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000348403100025en_US
dc.citation.woscount2en_US
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