標題: EFFICACY OF INTRAVITREAL INJECTION OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS FOR STAGE 4 RETINOPATHY OF PREMATURITY
作者: Cheng, Hui-Chen
Lee, Shui-Mei
Hsieh, Yi-Ting
Lin, Po-Kang
生醫電子轉譯研究中心
Biomedical Electronics Translational Research Center
關鍵字: anti-vascular endothelial growth factor;bevacizumab;ranibizumab;retinopathy of prematurity;Stage 4 retinopathy of prematurity
公開日期: 1-四月-2015
摘要: Purpose: To investigate the efficacy of intravitreal injection of anti-vascular endothelial growth factor agents for Stage 4 retinopathy of prematurity. Methods: Retrospective case series study. The medical records of patients receiving intravitreal injection of anti-vascular endothelial growth factor agents for Stage 4 retinopathy of prematurity from January 2007 to May 2012 in Taipei Veterans General Hospital were reviewed. Results: A total of 13 eyes of 7 patients (3 boys and 4 girls) with Stage 4 retinopathy of prematurity were included. The mean gestational age and birth weight were 27.6 +/- 2.6 weeks (range, 24.5-30.5 weeks) and 893.1 +/- 293.2 g (range, 550-1422 g), respectively. The mean age at the time of injection was 38.2 +/- 1.9 weeks (range, 36.0-41.5 weeks) post-menstrual age, and the mean follow-up period was 37.8 +/- 19.5 months (range, 11.0-67.5 months). The active neovascularization regressed rapidly, and the anatomical outcomes were favorable in all patients. One eye developed recurrent retinal hemorrhage with localized retinal detachment 21 weeks after initial treatment, which resolved after a second injection. There were no ocular or systemic complications in these patients. Conclusion: Intravitreal injection of anti-vascular endothelial growth factor agents may be effective as monotherapy or as supplement to failed laser treatment for patients with Stage 4 retinopathy of prematurity without additional surgical intervention. Further randomized controlled trials are necessary to compare the clinical efficacy and safety with other conventional interventions.
URI: http://hdl.handle.net/11536/124479
ISSN: 0275-004X
期刊: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Volume: 35
起始頁: 660
結束頁: 666
顯示於類別:期刊論文