標題: Unprecedented One-Pot Chemocontrolled Entry to Thioxoimidazolidinones and Aminoimidazolones: Synthesis of Kinase Inhibitor Leucettamine B
作者: Selvaraju, Manikandan
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: chemoselectivity;one-pot protocol;demino reactions;microwave chemistry;total synthesis
公開日期: 1-三月-2015
摘要: A novel and highly chemoselective protocol for the construction of thioxoimidazolidinone and aminoimidazolone frameworks was explored, and the influence of the reaction conditions on product formation was studied to establish two distinct approaches for their selective formation. In this one-pot reaction, ambient temperature generally resulted in the formation of thioxoimidazolidinones, whereas microwave irradiation provided aminoimidazolones exclusively. An attempt to elucidate the observed chemoselectivity is described, and the products were confirmed by X-ray studies. One-pot synthesis toward Leucettamine B, a marine alkaloid, was achieved on the basis of this protocol.
URI: http://dx.doi.org/10.1021/co500152s
http://hdl.handle.net/11536/124552
ISSN: 2156-8952
DOI: 10.1021/co500152s
期刊: ACS COMBINATORIAL SCIENCE
Volume: 17
起始頁: 182
結束頁: 189
顯示於類別:期刊論文