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dc.contributor.authorSelvaraju, Manikandanen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2015-07-21T08:28:40Z-
dc.date.available2015-07-21T08:28:40Z-
dc.date.issued2015-03-01en_US
dc.identifier.issn2156-8952en_US
dc.identifier.urihttp://dx.doi.org/10.1021/co500152sen_US
dc.identifier.urihttp://hdl.handle.net/11536/124552-
dc.description.abstractA novel and highly chemoselective protocol for the construction of thioxoimidazolidinone and aminoimidazolone frameworks was explored, and the influence of the reaction conditions on product formation was studied to establish two distinct approaches for their selective formation. In this one-pot reaction, ambient temperature generally resulted in the formation of thioxoimidazolidinones, whereas microwave irradiation provided aminoimidazolones exclusively. An attempt to elucidate the observed chemoselectivity is described, and the products were confirmed by X-ray studies. One-pot synthesis toward Leucettamine B, a marine alkaloid, was achieved on the basis of this protocol.en_US
dc.language.isoen_USen_US
dc.subjectchemoselectivityen_US
dc.subjectone-pot protocolen_US
dc.subjectdemino reactionsen_US
dc.subjectmicrowave chemistryen_US
dc.subjecttotal synthesisen_US
dc.titleUnprecedented One-Pot Chemocontrolled Entry to Thioxoimidazolidinones and Aminoimidazolones: Synthesis of Kinase Inhibitor Leucettamine Ben_US
dc.typeArticleen_US
dc.identifier.doi10.1021/co500152sen_US
dc.identifier.journalACS COMBINATORIAL SCIENCEen_US
dc.citation.volume17en_US
dc.citation.spage182en_US
dc.citation.epage189en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000350841000006en_US
dc.citation.woscount0en_US
Appears in Collections:Articles