標題: Microwave-assisted efficient conjugation of nanodiamond and paclitaxel
作者: Hsieh, Yi-Han
Liu, Kuang-Kai
Sulake, Rohidas S.
Chao, Jui-I.
Chen, Chinpiao
生物科技學系
Department of Biological Science and Technology
關鍵字: Nanodiamond;Paclitaxel;Microwave irradiating;Deaggregation;Lung cancer
公開日期: 15-五月-2015
摘要: Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond. (C) 2015 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bmcl.2015.03.089
http://hdl.handle.net/11536/124640
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2015.03.089
期刊: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume: 25
Issue: 10
起始頁: 2074
結束頁: 2077
顯示於類別:期刊論文