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dc.contributor.authorLiu, Wei-Hsiuen_US
dc.contributor.authorChen, Ming-Tehen_US
dc.contributor.authorWang, Mong-Lienen_US
dc.contributor.authorLee, Yi-Yenen_US
dc.contributor.authorChiou, Guang-Yuhen_US
dc.contributor.authorChien, Chian-Shiuen_US
dc.contributor.authorHuang, Pin-Ien_US
dc.contributor.authorChen, Yi-Weien_US
dc.contributor.authorHuang, Ming-Chaoen_US
dc.contributor.authorChiou, Shih-Hwaen_US
dc.contributor.authorShih, Yang-Hsinen_US
dc.contributor.authorMa, Hsin-Ien_US
dc.date.accessioned2015-07-21T08:29:02Z-
dc.date.available2015-07-21T08:29:02Z-
dc.date.issued2015-01-30en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://hdl.handle.net/11536/124717-
dc.description.abstractAtypical teratoid/rhabdoid tumor (ATRT) is a malignant pediatric brain tumor with great recurrence after complete surgery and chemotherapy. Here, we demonstrate that cisplatin treatment selects not only for resistance but also for a more oncogenic phenotype characterized by high self-renewal and invasive capabilities. These phenomena are likely due to STAT3 upregulatoin which occurred simultaneously with higher expression of Snail, an activator of epithelial-mesenchymal transition (EMT), in ATRT-CisR cells. STAT3 knockdown effectively suppressed Snail expression and blocked motility and invasion in ATRT-CisR cells, while overexpressing Snail reversed these effects. Chromatin immunoprecipitation assay indicated that STAT3 directly bound to Snail promoter. Moreover, STAT3 knockdown effectively suppressed cancer stem-like properties, synergistically enhanced the chemotherapeutic effect, and significantly improved survival rate in ATRT-CisR-transplanted immunocompromised mice. Finally, immunohistochemistrical analysis showed that STAT3 and Snail were coexpressed at high levels in recurrent ATRT tissues. Thus, the STAT3/Snail pathway plays an important role in oncogenic resistance, rendering cells not only drug-resistant but also increasingly oncogenic (invasion, EMT and recurrence). Therefore, the STAT3/Snail could be a target for ATRT treatment.en_US
dc.language.isoen_USen_US
dc.subjectAtypical teratoid/rhabdoid tumor (ATRT)en_US
dc.subjectSTAT3en_US
dc.subjectSnailen_US
dc.subjectoncogenic resistance and cisplatinen_US
dc.titleCisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cellsen_US
dc.typeArticleen_US
dc.identifier.journalONCOTARGETen_US
dc.citation.spage1750en_US
dc.citation.epage1768en_US
dc.contributor.department生物科技學院zh_TW
dc.contributor.departmentCollege of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000352689800035en_US
dc.citation.woscount0en_US
Appears in Collections:Articles