完整後設資料紀錄
DC 欄位語言
dc.contributor.authorJiang, Zhaoleien_US
dc.contributor.authorZhao, Yeen_US
dc.contributor.authorDoytchinova, Anisiiaen_US
dc.contributor.authorKamp, Nicholas J.en_US
dc.contributor.authorTsai, Wei-Chungen_US
dc.contributor.authorYuan, Yuanen_US
dc.contributor.authorAdams, Daviden_US
dc.contributor.authorWagner, Daviden_US
dc.contributor.authorShen, Changyuen_US
dc.contributor.authorChen, Lan S.en_US
dc.contributor.authorEverett, Thomas H.en_US
dc.contributor.authorLin, Shien-Fongen_US
dc.contributor.authorChen, Peng-Shengen_US
dc.date.accessioned2015-07-21T08:28:06Z-
dc.date.available2015-07-21T08:28:06Z-
dc.date.issued2015-06-01en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttp://hdl.handle.net/11536/124792-
dc.description.abstractBACKGROUND Stellate ganglion nerve activity (SGNA) is important in cardiac arrhythmogenesis. However, direct recording of SGNA requires access to the thoracic cavity. Skin of upper thorax is innervated by sympathetic nerve fibers originating from the stellate ganglia and is easily accessible. OBJECTIVE The purpose of this study was to test the hypothesis that thoracic skin nerve activity (SKNA) can be used to estimate SGNA. METHODS We recorded SGNA and SKNAs using surface electrocardiogram leads in 5 anesthetized and 4 ambulatory dogs. Apamin injected into the right stellate ganglion abruptly increased both right SGNA and SKNA in 5 anesthetized dogs. We integrated nerve activities and averaged heart rate in each 1-minure window over 10 minutes, We implanted a radiotransmitter to record Left SGNA in 4 ambulatory dogs (2 normal, 1 with myocardial infarction, 1 with intermittent rapid atrial pacing). After 2 weeks of recovery, we simultaneously recorded the SKNA and Left SGNA continuously for 30 minutes when the dogs were ambulatory. RESULTS There was a positive correlation [average r = 0.877, 95% confidence interval (CI) 0.732-1.000, P<.05 for each dog] between integrated skin nerve activity (iSKNA) and SGNA (iSGNA) and between iSKNA and heart rate (average r = 0.837, 95% CI 0.752-0.923, P<.05). Similar to that found in the anesthetized dogs, there was a positive correlation (average r = 0.746, 95% CI 0.527-0.964, P<.05) between iSKNA and iSGNA and between iSKNA and heart rate (average r = 0.706, 95% CI 0.484-0.927, P<.05). CONCLUSION SKNAs can be used to estimate SGNA in dogs.en_US
dc.language.isoen_USen_US
dc.subjectAutonomic nervous systemen_US
dc.subjectSympathetic nerveen_US
dc.subjectStellate ganglionen_US
dc.subjectCardiac arrhythmiaen_US
dc.titleUsing skin sympathetic nerve activity to estimate stellate ganglion nerve activity in dogsen_US
dc.typeArticleen_US
dc.identifier.journalHEART RHYTHMen_US
dc.citation.volume12en_US
dc.citation.spage1324en_US
dc.citation.epage1332en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000354821900036en_US
dc.citation.woscount0en_US
顯示於類別:期刊論文