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dc.contributor.authorHsieh, Yao-Yuanen_US
dc.contributor.authorChang, Chi-Chenen_US
dc.contributor.authorLin, Chich-Shengen_US
dc.date.accessioned2015-07-21T08:28:53Z-
dc.date.available2015-07-21T08:28:53Z-
dc.date.issued2006-01-01en_US
dc.identifier.issn1449-2288en_US
dc.identifier.urihttp://hdl.handle.net/11536/124854-
dc.description.abstractObjectives: Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. We aimed to evaluate the relationship of MDA and GPx levels with sperm parameters. Patients and methods: Specimens were divided into two groups: group 1. normospermia (n= 20); group 2. oligoasthenospermia (n= 31). Seminal MDA concentration was measured by thiobarbituric acid reaction method. Seminal GPx activity was measured by oxidation of reduced nicotinamide-adenine dinucleotide. Seminal MDA levels and GPx activities in both groups were compared. Results: MDA concentrations in both groups were significantly different (1.52 +/- 0.75 vs. 2.25 +/- 0.88 nM, p = 0.0021). GPx activities in both groups were non-significantly different (0.48 +/- 0.11 vs. 0.47 +/- 0.12 U/ml). MDA levels were negatively correlated with the sperm motility (MDA = -0.014 x motility + 2.62, p = 0.017) and concentration (MDA = -0.0045 x concentration + 2.23, p = 0.0166). GPx activities were positively but non-significantly correlated with the sperm concentration and sperm motility. Conclusions: Seminal MDA concentrations are negatively correlated with sperm concentration and motility, which might provide a simple and useful tool in predicting sperm parameters. GPx activity is non-significantly correlated with the seminal quality. Roles of seminal MDA upon spermatogenesis merits further surveys.en_US
dc.language.isoen_USen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectoligoasthenozoospermiaen_US
dc.subjectsemenen_US
dc.subjectspermen_US
dc.titleSeminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motilityen_US
dc.typeArticleen_US
dc.identifier.journalINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESen_US
dc.citation.spage23en_US
dc.citation.epage29en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000209398900004en_US
dc.citation.woscount41en_US
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