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dc.contributor.authorShaw, Fu-Zenen_US
dc.contributor.authorLee, Su-Yingen_US
dc.contributor.authorChiu, Ted H.en_US
dc.date.accessioned2014-12-08T15:17:13Z-
dc.date.available2014-12-08T15:17:13Z-
dc.date.issued2006-03-01en_US
dc.identifier.issn0161-8105en_US
dc.identifier.urihttp://hdl.handle.net/11536/12558-
dc.description.abstractStudy Objective: To clarify the cortical evoked responses in the primary somatosensory cortex of the rat under states of waking, slow-wave sleep (SWS), paradoxical sleep (PS), and spike-wave discharges (SWDs), which are associated with absence seizure. Design: Somatosensory evoked potentials (SEPs) in response to single- and paired-pulse stimulations under waking, SWS, PS, and SWDs were compared. SEPs to a single-pulse stimulus with regard to cortical spikes of sleep spindles and SWDs were also evaluated. Participants: Twenty Long Evans rats. Interventions: Single- and paired-pulse innocuous electrical stimulations were applied to the tail of rats with chronically implanted electrodes in the primary somatosensory cortex and neck muscle under waking, SWS, PS, and SWDs. Measurements and Results: SEPs displayed distinct patterns under waking/PS and SWS/SWDs. The short-latency P1-N1 wave of the SEP was severely impeded during SWDs but not in other states, Reduction of the P1-N1 magnitude to the second stimulus of the paired-pulse stimulus for interstimulus intervals of <= 300 milliseconds appeared in waking and PS states, but the decrease occurred only at particular interstimulus intervals under SWS. Interestingly, augmentation was found under SWDs. Moreover, cyclic augmentation of the P1-N1 magnitude was associated with spindle spikes, but cyclic reduction was observed with SWD spikes. Conclusion: Changes in SEPs are not only behavior dependent, but also phase locked onto ongoing brain activity. Distinct short-term plasticity of SEPs during sleep spindles or SWDs may merit further studies for seizure control and tactile information processing.en_US
dc.language.isoen_USen_US
dc.subjectabsence seizureen_US
dc.subjectsleep spindleen_US
dc.subjectslow-wave sleepen_US
dc.subjectplasticityen_US
dc.subjectbursten_US
dc.subjectadaptationen_US
dc.titleModulation of somatosensory evoked potentials during wake-sleep states and spike-wave discharges in the raten_US
dc.typeArticleen_US
dc.identifier.journalSLEEPen_US
dc.citation.volume29en_US
dc.citation.issue3en_US
dc.citation.spage285en_US
dc.citation.epage293en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000240123600003-
dc.citation.woscount13-
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