標題: | Electrical-Sensitive Nanoparticle Composed of Chitosan and Tetraethyl Orthosilicate for Controlled Drug Release |
作者: | Liu, Kun-Ho Liu, Ting-Yu Liu, Dean-Mo Chen, San-Yuan 材料科學與工程學系 Department of Materials Science and Engineering |
關鍵字: | Polyelectrolyte;Electric-Stimuli;Nanoparticle |
公開日期: | 1-二月-2009 |
摘要: | In the present study, the nanoparticles with size of 50-130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-control led release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off." |
URI: | http://dx.doi.org/10.1166/jnn.2009.C119 http://hdl.handle.net/11536/12723 |
ISSN: | 1533-4880 |
DOI: | 10.1166/jnn.2009.C119 |
期刊: | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY |
Volume: | 9 |
Issue: | 2 |
起始頁: | 1198 |
結束頁: | 1203 |
顯示於類別: | 會議論文 |