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dc.contributor.authorChan, Yi-Hsinen_US
dc.contributor.authorTsai, Wei-Chungen_US
dc.contributor.authorShen, Changyuen_US
dc.contributor.authorHan, Seongwooken_US
dc.contributor.authorChen, Lan S.en_US
dc.contributor.authorLin, Shien-Fongen_US
dc.contributor.authorChen, Peng-Shengen_US
dc.date.accessioned2015-12-02T02:59:09Z-
dc.date.available2015-12-02T02:59:09Z-
dc.date.issued2015-07-01en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.hrthm.2015.03.025en_US
dc.identifier.urihttp://hdl.handle.net/11536/127870-
dc.description.abstractBACKGROUND We recently reported that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone. OBJECTIVE The purpose of this study was to test the hypothesis that left thoracic SCNA is more accurate than heart rate variability (HRV) in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction (MI). METHODS We used an implanted radiotransmitter to study left stellate ganglion nerve activity (SGNA), vagal nerve activity (VNA), and thoracic SCNA in 9 dogs at baseline and up to 8 weeks after MI. HRV was determined based on time-domain, frequency-domain, and nonlinear analyses. RESULTS The correlation coefficients between integrated SGNA and SCNA averaged 0.74 (95% confidence interval [CI] 0.41-1.06) at baseline and 0.82 (95% CI, 0.63-1.01) after MI (P <.05 for both). The absolute values of the correlation coefficients were significantly larger than that between SGNA and HRV analysis based on time-domain, frequency-domain, and nonlinear analyses, respectively, at baseline (P <.05 for all) and after MI (P <.05 for all). There was a clear increment of SGNA and SCNA at 2, 4, 6, and 8 weeks after MI, whereas HRV parameters showed no significant changes. Significant circadian variations were noted in SCNA, SGNA, and all HRV parameters at baseline and after MI, respectively. Atrial tachycardia (AT) episodes were invariably preceded by SCNA and SGNA, which were progressively increased from 120th, 90th, 60th, to 30th seconds before AT onset. No such changes of HRV parameters were observed before AT onset. CONCLUSION SCNA is more accurate than HRV in estimating cardiac sympathetic tone in ambulatory dogs with MI.en_US
dc.language.isoen_USen_US
dc.subjectHeart rate variabilityen_US
dc.subjectAutonomic nervous systemen_US
dc.subjectSubcutaneous nerve activityen_US
dc.subjectMyocardial infarctionen_US
dc.subjectAtrial arrhythmiaen_US
dc.titleSubcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarctionen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.hrthm.2015.03.025en_US
dc.identifier.journalHEART RHYTHMen_US
dc.citation.volume12en_US
dc.citation.spage1619en_US
dc.citation.epage1627en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000356766500038en_US
dc.citation.woscount0en_US
Appears in Collections:Articles