標題: Highly Selective Dissociation of a Peptide Bond Following Excitation of Core Electrons
作者: Lin, Yi-Shiue
Tsai, Cheng-Cheng
Lin, Huei-Ru
Hsieh, Tsung-Lin
Chen, Jien-Lian
Hu, Wei-Ping
Ni, Chi-Kung
Liu, Chen-Lin
應用化學系
Department of Applied Chemistry
公開日期: 18-六月-2015
摘要: The controlled breaking of a specific chemical bond with photons in complex molecules remains a major challenge in chemistry. In principle, using the K-edge absorption of a particular atomic element, one might excite selectively a specific atomic entity in a molecule. We report here highly selective dissociation of the peptide bonds in N-methylformamide and N-methylacetamide on tuning the X-ray wavelength to the K-edge absorption of the atoms connected to (or near) the peptide bond. The high selectivity (56-71%) of this cleavage arises from the large energy shift of X-ray absorption, a large overlap of the Is orbital and the valence pi* orbital that is highly localized on a peptide bond with antibonding character, and the relatively low bond energy of the peptide bonds. These characteristics indicate that the high selectivity on bond dissociation following core excitation could be a general feature for molecules containing peptide bonds.
URI: http://dx.doi.org/10.1021/acs.jpca.5b04415
http://hdl.handle.net/11536/127885
ISSN: 1089-5639
DOI: 10.1021/acs.jpca.5b04415
期刊: JOURNAL OF PHYSICAL CHEMISTRY A
Volume: 119
Issue: 24
起始頁: 6195
結束頁: 6202
顯示於類別:期刊論文